The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Diverse roles of fatty acid binding proteins (FABPs) in development and pathogenesis of cancers

(2018) Mina Amiri et al.   GENE

Insights into the Role of PPARβ/δ in NAFLD

(2018) Jiapeng Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome

(2017) Chek Kun Tan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions

(2017) Y-J Li et al.   LEUKEMIA

Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ

(2017) Chyuan-Chuan Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationally designed PPARδ-specific agonists and their therapeutic potential for metabolic syndrome

(2017) Rebecca L. Cox   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia

(2017) Marcela Doktorova et al.   Scientific Reports

PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis

(2016) P Luz-Crawford et al.   ANNALS OF THE RHEUMATIC DISEASES

PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice

(2016) Wai San Cheang et al.   DIABETES

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ

(2016) Nguan Soon Tan et al.   PROGRESS IN LIPID RESEARCH

PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions

(2016) X Wang et al.   Oncogenesis

15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway

(2015) Fei Mao et al.   FASEB JOURNAL

The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state

(2015) Till Adhikary et al.   NUCLEIC ACIDS RESEARCH

Establishing the Role of PPARβ/δ in Carcinogenesis

(2015) Jeffrey M. Peters et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

(2014) Amirhossein Sahebkar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway

(2014) Eric H. Armstrong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Potentiation of Colon Cancer Susceptibility in Mice by Colonic Epithelial PPAR-δ/β Overexpression

(2014) Xiangsheng Zuo et al.   JNCI-Journal of the National Cancer Institute

Peroxisome proliferator-activated receptor   promotes colonic inflammation and tumor growth

(2014) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-Associated Macrophages Contribute to Tumor Progression in Ovarian Cancer

(2014) Emily K. Colvin   Frontiers in Oncology

PPAR  Induces Estrogen Receptor-Positive Mammary Neoplasia through an Inflammatory and Metabolic Phenotype Linked to mTOR Activation

(2013) H. Yuan et al.   CANCER RESEARCH

PPARδ promotes oncogenic redirection of TGF-β1 signaling through the activation of the ABCA1-Cav1 pathway

(2013) Nam-Hu Her et al.   CELL CYCLE

Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells

(2013) Tianyi Tang et al.   Cell Metabolism

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

(2013) Maria Ester Bernardo et al.   Cell Stem Cell

PPARβ/δ governs Wnt signaling and bone turnover

(2013) Carina Scholtysek et al.   NATURE MEDICINE

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: How to aim?

(2012) Min Xu et al.   BIOCHEMICAL PHARMACOLOGY

Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies

(2012) Tine Jess et al.   Clinical Gastroenterology and Hepatology

Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism

(2012) Mi Young Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

(2012) José Iglesias et al.   JOURNAL OF CLINICAL INVESTIGATION

A metabolic prosurvival role for PML in breast cancer

(2012) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases

(2012) Je-Min Choi et al.   MOLECULES AND CELLS

Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding

(2012) Fernanda A. H. Batista et al.   PLoS One

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PPARs and Lipid Ligands in Inflammation and Metabolism

(2011) Gregory S. Harmon et al.   CHEMICAL REVIEWS

Activation of Peroxisome Proliferator–Activated Receptor δ Inhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice

(2011) Yuichi Matsushita et al.   DIABETES

The Expression of Both Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 in Tissues Is Associated with Poor Prognosis in Colorectal Cancer Patients

(2010) Masahiro Yoshinaga et al.   DIGESTIVE DISEASES AND SCIENCES

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Peroxisome proliferator-activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

(2010) Saravanan Kanakasabai et al.   IMMUNOLOGY

Peroxisome proliferator–activated receptor δ limits the expansion of pathogenic Th cells during central nervous system autoimmunity

(2010) Shannon E. Dunn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Activation of PPARβ/δ Causes a Psoriasis-Like Skin Disease In Vivo

(2010) Malgorzata Romanowska et al.   PLoS One

Coactivators in PPAR-Regulated Gene Expression

(2010) Navin Viswakarma et al.   PPAR Research

PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

(2009) Kim Ravnskjaer et al.   JOURNAL OF LIPID RESEARCH

Targeted Genetic Disruption of Peroxisome Proliferator–Activated Receptor-δ and Colonic Tumorigenesis

(2009) Xiangsheng Zuo et al.   JNCI-Journal of the National Cancer Institute

15-Hydroxyeicosatetraenoic Acid Is a Preferential Peroxisome Proliferator-Activated Receptor  /  Agonist

(2009) S. Naruhn et al.   MOLECULAR PHARMACOLOGY

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

(2009) Kay-Dietrich Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Peroxisome Proliferator–Activated Receptor β/δ Expression and Activation in Lung Cancer

(2008) Tetyana V. Pedchenko et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

PPARδ is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer

(2008) Mallika Ghosh et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS