PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions

Identification of the first potent, selective and bioavailable PPARα antagonist

(2014) Yalda Bravo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Nuclear Receptor Peroxisome Proliferator-activated Receptor-β/δ (PPARβ/δ) Promotes Oncogene-induced Cellular Senescence through Repression of Endoplasmic Reticulum Stress

(2014) Bokai Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies

(2014) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of Peroxisome Proliferator-Activated Receptor- /  (PPAR- / ) Inhibits Human Breast Cancer Cell Line Tumorigenicity

(2014) P.-L. Yao et al.   MOLECULAR CANCER THERAPEUTICS

Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain

(2013) Stepan Aleshin et al.   BIOLOGICAL CHEMISTRY

PPAR  and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia

(2013) S. Tung et al.   BLOOD

Cure of metastatic growth of EMT6 tumor cells in mice following manipulation of CD200:CD200R signaling

(2013) Reginald M. Gorczynski et al.   BREAST CANCER RESEARCH AND TREATMENT

PPAR  Induces Estrogen Receptor-Positive Mammary Neoplasia through an Inflammatory and Metabolic Phenotype Linked to mTOR Activation

(2013) H. Yuan et al.   CANCER RESEARCH

Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells

(2013) Tianyi Tang et al.   Cell Metabolism

Tackling the Diversity of Triple-Negative Breast Cancer

(2013) N. C. Turner et al.   CLINICAL CANCER RESEARCH

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

(2013) Hyeonju Yeo et al.   EMBO JOURNAL

mda- 7/IL-24 Expression Inhibits Breast Cancer through Upregulation of Growth Arrest-Specific Gene 3 ( gas3 ) and Disruption of β1 Integrin Function

(2013) You-Jun Li et al.   MOLECULAR CANCER RESEARCH

Site-specific activation of AKT protects cells from death induced by glucose deprivation

(2013) M Gao et al.   ONCOGENE

Cell Survival Signalling through PPARδ and Arachidonic Acid Metabolites in Neuroblastoma

(2013) Emma Bell et al.   PLoS One

Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response

(2013) R Palorini et al.   Cell Death & Disease

A Comprehensive Nuclear Receptor Network for Breast Cancer Cells

(2013) Ralf Kittler et al.   Cell Reports

Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4

(2012) Combiz Khozoie et al.   BMC GENOMICS

Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors

(2012) Chan Yeom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A metabolic prosurvival role for PML in breast cancer

(2012) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

(Z)-2-(2-Bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An Orally Bioavailable PPARβ/δ-Selective Ligand with Inverse Agonistic Properties

(2012) Sonja Lieber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion

(2012) T Adhikary et al.   ONCOGENE

Vascular effects of prostacyclin: does activation of PPARδ play a role?

(2012) Zvonimir S. Katusic et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia

(2011) J. Tomic et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PPARs and Lipid Ligands in Inflammation and Metabolism

(2011) Gregory S. Harmon et al.   CHEMICAL REVIEWS

Development of Improved PPARβ/δ Inhibitors

(2011) Philipp M. Toth et al.   ChemMedChem

VLDL Hydrolysis by Hepatic Lipase Regulates PPARδ Transcriptional Responses

(2011) Jonathan D. Brown et al.   PLoS One

Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

(2010) Barry G. Shearer et al.   JOURNAL OF MEDICINAL CHEMISTRY

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

15-Hydroxyeicosatetraenoic Acid Is a Preferential Peroxisome Proliferator-Activated Receptor  /  Agonist

(2009) S. Naruhn et al.   MOLECULAR PHARMACOLOGY

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

PPARδ Is a Type 1 IFN Target Gene and Inhibits Apoptosis in T Cells

(2008) Nadya al Yacoub et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist

(2007) Barry G. Shearer et al.   MOLECULAR ENDOCRINOLOGY