Article
Cell Biology
Rita Dreier, Thomas Ising, Markus Ramroth, Yvonne Rellmann
Summary: Gender differences in osteoarthritis (OA) may be attributed to the differential response of males and females to endoplasmic reticulum (ER) stress in articular chondrocytes. This study demonstrates that the female sex hormone estradiol can reduce ER stress and ER stress-induced apoptosis in articular chondrocytes, thus minimizing critical events favoring osteoarthritic cartilage degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Qin Tang, Qinhui Liu, Jiahui Li, Jiamin Yan, Xiandan Jing, Jinhang Zhang, Yan Xia, Ying Xu, Yanping Li, Jinhan He
Summary: This study demonstrates the importance of MANF in POMC neurons for the regulation of energy balance and obesity prevention. Lack of MANF in POMC neurons increases the risk of diet-induced obesity, while overexpression of MANF in these neurons protects against dietary obesity by promoting thermogenesis in brown adipose tissue.
Article
Endocrinology & Metabolism
Yinqiong Huang, Qinyu Liu, Guifeng Huang, Junping Wen, Gang Chen
Summary: Stress affects energy metabolism and reproduction through the glucocorticoid receptor on Kisspeptin neurons in the hypothalamus, leading to weight loss and negative changes in reproductive function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marwa Mohamed Atef, Marwa Nagy Emam, Rehab E. Abo El Gheit, Eman M. Elbeltagi, H. A. Alshenawy, Doaa A. Radwan, Reham L. Younis, Rania Nagi Abd-Ellatif
Summary: This study aimed to examine the protective effect of Geraniol (GE) on D-galactose (D-gal) induced cognitive impairment. The results showed that GE effectively improved aging-related memory impairment through increasing GSH, BDNF, Ach levels, and SOD activity. Additionally, GE treatment caused a decrease in the levels of MDA, inflammatory mediators, ER stress sensors, and AchE activity, as well as improved neuronal architecture and spatial memory.
NEUROCHEMICAL RESEARCH
(2022)
Article
Food Science & Technology
Mengcong Li, Shuhui Liu, Lei Tan, Yan Luo, Zhangshan Gao, Jiwen Liu, Yuting Wu, Wentao Fan, Sarah DeSaeger, Suquan Song
Summary: This study found that FB1 contamination has a toxic effect on the intestine and disrupts its barrier function. FB1 also leads to excessive production of cytokines, further damaging the intestinal immune barrier. By inhibiting the expression of CerS2, FB1 induces endoplasmic reticulum stress, resulting in the destruction of the intestinal barrier. However, this damage can be restored by overexpression of CerS2 or the use of an ER stress inhibitor.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Zhu, Bin Li, Dongqin Chen, Ning Chen, Le Xu, Qinjin Li, Xiaodong Chen
Summary: This study investigated the role of STEAP4 in maintaining cellular homeostasis and improving oxidative stress caused by a high-fat diet in hepatocytes. The results showed that STEAP4 could alleviate oxidative stress and enhance the viability of hepatocytes. It was found to regulate insulin signaling and antioxidant pathways, as well as the communication of energy between the endoplasmic reticulum and mitochondria.
Article
Neurosciences
Yun Lim, Seolsong Kim, Eun-Kyoung Kim
Summary: The research suggests that palmitate can reduce hypothalamic cell stress induced by starvation by inhibiting ER-phagy, thus lowering the level of ER stress.
Article
Cell Biology
Yun Cao, Zhaowei Chen, Jijia Hu, Jun Feng, Zijing Zhu, Yanqin Fan, Qiaoxuan Lin, Guohua Ding
Summary: In this study, it was confirmed that Mfn2 regulates the morphology and functions of MAMs and mitochondria, and exerts anti-apoptotic effects on podocytes by inhibiting the PERK pathway. The Mfn2-PERK signaling pathway may be a new therapeutic target for preventing podocyte injury in DKD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Valeria C. Torres Irizarry, Yuwei Jiang, Yanlin He, Pingwen Xu
Summary: Obesity is a global epidemic and is associated with other metabolic disorders. Sex-specific metabolic protection and disease susceptibility play an important role, with estrogen hormone regulating fat distribution and metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Neurosciences
Ruqin Zhou, Meng He, Jun Fan, Ruoxi Li, Yufeng Zuo, Benben Li, Guanbin Gao, Taolei Sun
Summary: Schizophrenia and antipsychotic-induced weight gain/obesity may be associated with hypothalamic endoplasmic reticulum stress pathway, which could lead to multiple changes in the body including hyperphagia, decreased energy expenditure, and central inflammation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Bora Jeong, Kwang-Kon Kim, Tae-Hwan Lee, Han-Rae Kim, Byong-Seo Park, Jeong-Woo Park, Jin-Kwon Jeong, Jae-Young Seong, Byung-Ju Lee
Summary: This study found that SPX mediates the effect of leptin on energy homeostasis in the hypothalamus. Administration of SPX reduced food intake and body weight gain, and SPX expression was found in leptin receptor ObRb-positive cells in the hypothalamus. Leptin increased SPX expression and this effect was mediated by the STAT3 pathway.
Article
Microbiology
Xingang Xu, Yi Liu, Jie Gao, Xiaojie Shi, Yuchao Yan, Naling Yang, Quanqiong Wang, Qi Zhang
Summary: This study revealed the mechanism by which GRAMD4 was associated with ER stress and apoptosis regulating PEDV replication. NSP6 acted as a potential down-regulator of GRAMD4 and promoted the degradation of GRAMD4. GRAMD4 played a role in facilitating apoptosis and restricting virus replication, and the GRAM domain was required.
VETERINARY MICROBIOLOGY
(2023)
Review
Medicine, Research & Experimental
Ranmali Ranasinghe, Michael Mathai, Anthony Zulli
Summary: This review aims to provide a comprehensive collection of potential cytoprotective remedies in overcoming nephrotoxicity caused by anti-neoplastic drug metabolism and renal oxidative stress. There is an increasing need for renal replacement therapy and higher mortality rates from end-stage renal disease in the next decade, making the discussion of 43 different cytoprotective compounds crucial.
Article
Endocrinology & Metabolism
Cecilie Hundahl, Petra Kotzbeck, Hayley B. Burm, Soren H. Christiansen, Lola Torz, Aske W. Helge, Martin P. Madsen, Cecilia Ratner, Annette K. Serup, Jonatan J. Thompson, Thomas O. Eichmann, Tune H. Pers, David P. D. Woldbye, Daniele Piomelli, Bente Kiens, Rudolf Zechner, Louise J. Skov, Birgitte Holst
Summary: The study reveals the significance of central HSL in regulating food intake and body weight under conditions of acute stress and high-fat diet in mice, shedding light on the role of intracellular lipolysis in mammalian hypothalamus in appetite regulation.
MOLECULAR METABOLISM
(2021)
Article
Hematology
Brittany C. Lipchick, Adam Utley, Zhannan Han, Sudha Moparthy, Dong Hyun Yun, Anna Bianchi-Smiraglia, David W. Wolff, Emily Fink, Liang Liu, Cristina M. Furdui, Jingyun Lee, Kelvin P. Lee, Mikhail A. Nikiforov
Summary: This study identified the role of lipid metabolism in the resistance of multiple myeloma cells to the proteasome inhibitor bortezomib. Lower levels of fatty acid elongase 6 (ELOVL6) were found in bortezomib-nonresponsive MM cells compared to bortezomib-responsive cells. Restoring ELOVL6 levels resensitized resistant cells by upregulating ceramide species, essential for bortezomib-induced endoplasmic reticulum stress and cell death.
Editorial Material
Gastroenterology & Hepatology
Ruben Nogueiras, Patricia Aspichueta
JOURNAL OF HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Edward Milbank, Nathalia Dragano, Xavi Vidal-Gomez, Veronica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, Maria P. Pata, Jose Luis Labandeira-Garcia, Carlos Dieguez, Ruben Nogueiras, M. Carmen Martinez, Ramaroson Andriantsitohaina, Miguel Lopez
Summary: The study found that using a specific type of extracellular vesicles loaded with a defective AMPK alpha 1 gene can alleviate symptoms such as obesity and metabolic disorders in mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Editorial Material
Endocrinology & Metabolism
Vincent Prevot, Ruben Nogueiras
Summary: Food odour recognition is involved in food anticipatory response. A study in Nature Metabolism explains how the olfactory system regulates metabolic adaptations based on energy availability. These effects are controlled by a brain circuit involving the melanocortin system, which regulates systemic lipid utilization through the sympathetic nervous system.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Miguel Lopez, Manuel Fernandez-Real, Stanislav I. Tomarev
Summary: Classically, the regulation of energy balance has been based on central and peripheral mechanisms sensing energy, nutrients, metabolites, and hormonal cues. Recent data have added more complexity to the homeostatic regulation of metabolism by introducing the key role of olfaction in energy homeostasis. Olfactory inputs contribute to the regulation of feeding, energy expenditure, and whole body metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Sayani Mukherjee, Carlos Dieguez, Johan Ferno, Miguel Lopez
Summary: Currently, there are various pharmacological therapies available for treating obesity, impacting both the central nervous system and peripheral tissues. Small extracellular vesicles (sEVs) have gained attention for their role in pathophysiological conditions due to their unique nano-sized structure and contents. In addition to transferring molecules between cells, sEVs can also modify the characteristics of recipient cells. This review explores the potential of utilizing sEVs as a CNS-targeted strategy for treating obesity and discusses the translation of current findings, such as sEV-mediated targeting of hypothalamic AMP-activated protein kinase (AMPK), into clinical application.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Sebastian Zagmutt, Paula Mera, Ismael Gonzalez-Garcia, Kevin Ibeas, Maria del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M. Carmen Soler-Vazquez, Marianela Bastias-Perez, Laia Canes, Elisabeth Auge, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi Garcia, Jose Martinez-Gonzalez, Nuria Casals, Miguel Lopez, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serra
Summary: Fatty acid metabolism and CPT1A in AgRP neurons play a key role in the maintenance of whole-body fluid and energy balance. This study reveals marked sex differences in fatty acid metabolism and CPT1A expression in AgRP neurons.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Ruben Nogueiras, Michael A. A. Nauck, Matthias H. H. Tschoep
Summary: The discovery and development of gut hormone co-agonists have revolutionized the treatment of diabetes and obesity. These therapeutics combine multiple gastrointestinal hormones into a single molecule, resulting in synergistic metabolic benefits. The GLP-1-GIP co-agonist tirzepatide, approved in 2022, has shown superior HbA1c reduction and significant weight loss in non-diabetic individuals with obesity.
Article
Biochemistry & Molecular Biology
Justine Lallement, Ilyes Raho, Gregory Merlen, Dominique Rainteau, Mikael Croyal, Melody Schiffano, Nadim Kassis, Isabelle Doignon, Maud Soty, Floriane Lachkar, Michel Krempf, Matthias Van Hul, Patrice D. Cani, Fabienne Foufelle, Chloe Amouyal, Herve Le Stunff, Christophe Magnan, Thierry Tordjmann, Celine Cruciani-Guglielmacci
Summary: This study aimed to determine the role of de novo hepatic ceramide synthesis in energy and liver homeostasis. The results showed that mice lacking the Sptlc2 gene were protected against obesity induced by high fat diet and displayed a defect in lipid absorption. In addition, the deficiency enhanced glucose tolerance and attenuated hepatic glucose production, while the latter effect was dampened in presence of nSMase2 inhibitor. Furthermore, Sptlc2 disruption promoted apoptosis, inflammation, and progressive development of hepatic fibrosis. These findings highlight the importance of ceramides in liver homeostasis and metabolic functions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Nutrition & Dietetics
Charlotte Corporeau, Christelle Le Foll, Celine Cruciani-Guglielmacci, Herve Le Stunff, Gilles Mithieux, Christophe Magnan, Jacques Delarue
Summary: LC n-3 PUFA can reduce weight gain and improve liver insulin resistance in obese rats, possibly by alleviating hypothalamic lipotoxicity.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hugo Martin, Adeline Coursan, Justine Lallement, Mathieu Di Miceli, Janany Kandiah, Ilyes Raho, Jasmine Buttler, Jean-Philippe Guilloux, Philippe De Deurwaerdere, Sophie Laye, Vanessa H. Routh, Bruno P. Guiard, Christophe Magnan, Celine Cruciani-Guglielmacci, Xavier Fioramonti
Summary: This study aimed to determine the contribution of serotonin (5-HT) neurons in the regulation of the counter-regulatory response (CRR). The results showed that 5-HT neurons can detect iatrogenic hypoglycemia in response to increased insulin levels and may play an important role in the regulation of CRR.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Olga Barca-Mayo, Miguel Lopez
Summary: Ovarian estradiol and leptin play important roles in regulating whole-body energy balance in the hypothalamus. In a recent paper in Cell Metabolism, Gonzalez-Garcia et al. demonstrate that CITED1 acts as a key hypothalamic cofactor that enhances the anorectic effects of leptin, mediating the antiobesity effects of estradiol.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Pharmacology & Pharmacy
Ismael Gonzalez-Garcia, Miguel Lopez
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Editorial Material
Endocrinology & Metabolism
Ismael Gonzalez-Garcia, Cristina Garcia-Caceres
Summary: Sa et al. discovered a specific group of neurons that regulate the generation of heat in brown adipose tissue. In mice fed with a high-fat diet, hypothalamic GABRA5 neurons are deactivated by GABA released by surrounding astrocytes, and inhibiting GABA synthesis improves diet-induced obesity.
