Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors

The role of xanthine oxidoreductase and uric acid in metabolic syndrome

(2018) Maria Giulia Battelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

(2018) Chelsea L. Dieck et al.   CANCER CELL

Interplay between adenylate metabolizing enzymes and AMP-activated protein kinase

(2018) Marcella Camici et al.   FEBS Journal

Anorexia nervosa and uric acid beyond gout: An idea worth researching

(2018) Mladena Simeunovic Ostojic et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

The Inside Story of Adenosine

(2018) Marcella Camici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Adenosine A3 Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia

(2018) René Rocha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation

(2018) Aleš Hnízda et al.   LEUKEMIA

A review of HPRT and its emerging role in cancer

(2018) Michelle H. Townsend et al.   MEDICAL ONCOLOGY

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

(2018) Gannie Tzoneva et al.   NATURE

Adenosine deaminase deficiency: a review

(2018) Aisling M. Flinn et al.   Orphanet Journal of Rare Diseases

Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms

(2018) Carrie Wahlman et al.   PAIN

Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study

(2018) Xinxin Huang et al.   PARKINSONISM & RELATED DISORDERS

Cumulative experience and long term follow-up of pentostatin-based chemoimmunotherapy trials for patients with chronic lymphocytic leukemia

(2018) Neil E. Kay et al.   Expert Review of Hematology

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity

(2018) Daniel Poppe et al.   Stem Cells Translational Medicine

Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy

(2018) Ágatha Oliveira-Giacomelli et al.   Frontiers in Pharmacology

Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders

(2018) Anindya Bhattacharya   Frontiers in Pharmacology

Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins

(2018) Estefanía Moreno et al.   Frontiers in Pharmacology

Cytosolic 5′-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

(2018) Rossana Pesi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor-dependent mechanisms

(2018) Barbara Kutryb-Zajac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Upregulation of Neuronal Adenosine A1 Receptor in Human Rasmussen Encephalitis

(2017) Guoming Luan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hypoxanthine Induces Neuroenergetic Impairment and Cell Death in Striatum of Young Adult Wistar Rats

(2017) Helena Biasibetti-Brendler et al.   MOLECULAR NEUROBIOLOGY

A New View into the Regulation of Purine Metabolism: The Purinosome

(2017) Anthony M. Pedley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane

(2017) Michelle Townsend et al.   OncoTargets and Therapy

The cytosolic 5’-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells

(2017) Gabriel Bricard et al.   Oncotarget

Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients

(2017) Aisha V. Sauer et al.   Scientific Reports

Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases

(2017) Marta Fumagalli et al.   Frontiers in Pharmacology

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

(2017) Usama A.A. Sharaf El Din et al.   Journal of Advanced Research

Whole genome sequencing identifies a novel homozygous exon deletion in the NT5C2 gene in a family with intellectual disability and spastic paraplegia

(2017) Hossein Darvish et al.   npj Genomic Medicine

Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency

(2016) Maria Pia Cicalese et al.   BLOOD

Purines: forgotten mediators in traumatic brain injury

(2016) Edwin K. Jackson et al.   JOURNAL OF NEUROCHEMISTRY

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

New Strategy That Delays Progression of Amyotrophic Lateral Sclerosis in G1H-G93A Transgenic Mice: Oral Administration of Xanthine Oxidoreductase Inhibitors That Are Not Substrates for the Purine Salvage Pathway

(2016) Shinsuke Kato et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity

(2016) U. S. Sandau et al.   JOURNAL OF NEUROSCIENCE

Hypoxanthine Intrastriatal Administration Alters Neuroinflammatory Profile and Redox Status in Striatum of Infant and Young Adult Rats

(2016) Helena Biasibetti et al.   MOLECULAR NEUROBIOLOGY

Purinergic neurone-glia signalling in cognitive-related pathologies

(2016) Peter Illes et al.   NEUROPHARMACOLOGY

Adenosinergic signaling in epilepsy

(2016) Detlev Boison   NEUROPHARMACOLOGY

A review of the implication of hypoxanthine excess in the physiopathology of Lesch–Nyhan disease

(2016) R. J. Torres et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis

(2016) Medi Kori et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Metabolic features of chronic fatigue syndrome

(2016) Robert K. Naviaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells

(2016) Angelo Torres et al.   Oncotarget

Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation

(2016) Katharina Kiese et al.   Frontiers in Molecular Neuroscience

Adenosine Deaminase Deficiency – More Than Just an Immunodeficiency

(2016) Kathryn V. Whitmore et al.   Frontiers in Immunology

Determination of the enzymatic activity of cytosolic 5′-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models

(2015) Lars Petter Jordheim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

IMP–GMP specific cytosolic 5′-nucleotidase regulates nucleotide pool and prodrug metabolism

(2015) Federico Cividini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The druggability of intracellular nucleotide-degrading enzymes

(2015) Chiara Rampazzo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development

(2015) Matthew L. Diamond et al.   EPILEPSIA

Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis

(2015) Seng kah Ng et al.   EXPERIMENTAL NEUROLOGY

A phase II multi-center trial of pentostatin plus cyclophosphamide with ofatumumab in older previously untreated chronic lymphocytic leukemia patients

(2015) A. Tedeschi et al.   HAEMATOLOGICA

Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5′-nucleotidase II

(2015) F. Cividini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial Damage and Apoptosis Induced by Adenosine Deaminase Inhibition and Deoxyadenosine in Human Neuroblastoma Cell Lines

(2015) Mercedes Garcia-Gil et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Association between serum uric acid and motor subtypes of Parkinson’s disease

(2015) Praween Lolekha et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options

(2015) Christian Staufner et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Hypoxanthine deregulates genes involved in early neuronal development. Implications in Lesch-Nyhan disease pathogenesis

(2015) R. J. Torres et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Adenosine Kinase Expression in Cortical Dysplasia With Balloon Cells

(2015) Guoming Luan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Clinical severity in Lesch–Nyhan disease: The role of residual enzyme and compensatory pathways

(2015) Rong Fu et al.   MOLECULAR GENETICS AND METABOLISM

Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma-associated epilepsy

(2015) JUN HUANG et al.   Molecular Medicine Reports

The combination of adenosine deaminase inhibition and deoxyadenosine induces apoptosis in a human astrocytoma cell line

(2015) Mercedes Garcia-Gil et al.   NEUROCHEMISTRY INTERNATIONAL

Comorbidities in Neurology: Is adenosine the common link?

(2015) Detlev Boison et al.   NEUROPHARMACOLOGY

Alzheimer’s disease shares gene expression aberrations with purinergic dysregulation of HPRT deficiency (Lesch–Nyhan disease)

(2015) Tae Hyuk Kang et al.   NEUROSCIENCE LETTERS

Purinosome formation as a function of the cell cycle

(2015) Chung Yu Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity

(2015) Prabarna Ganguly et al.   Developmental Cognitive Neuroscience

A phase II multi-center trial of pentostatin plus cyclophosphamide with ofatumumab in older previously untreated chronic lymphocytic leukemia patients

(2015) A. Tedeschi et al.   HAEMATOLOGICA

Cytosolic 5’-Nucleotidase II Interacts with the Leucin Rich Repeat of NLR Family Member Ipaf

(2015) Federico Cividini et al.   PLoS One

Inosine improves functional recovery after experimental traumatic brain injury

(2014) Shlomit Dachir et al.   BRAIN RESEARCH

Correlation of Fatigue During the Acute Stage of Stroke with Serum Uric Acid and Glucose Levels, Depression, and Disability

(2014) Dan Wu et al.   EUROPEAN NEUROLOGY

Urate and neuroprotection trials

(2014) Michael A Schwarzschild et al.   LANCET NEUROLOGY

Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial

(2014) Ángel Chamorro et al.   LANCET NEUROLOGY

Brain white matter volume abnormalities in Lesch-Nyhan disease and its variants

(2014) D. J. Schretlen et al.   NEUROLOGY

Striatal Neurodevelopment Is Dysregulated in Purine Metabolism Deficiency and Impacts DARPP-32, BDNF/TrkB Expression and Signaling: New Insights on the Molecular and Cellular Basis of Lesch-Nyhan Syndrome

(2014) Ghiabe-Henri Guibinga et al.   PLoS One

Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders

(2014) G. Novarino et al.   SCIENCE

Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate

(2013) Alla Fridman et al.   BIOCHEMICAL JOURNAL

Role of the A2Breceptor-adenosine deaminase complex in colonic dysmotility associated with bowel inflammation in rats

(2013) L Antonioli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic Perspectives for cN-II in Cancer.

(2013) Lars Jordheim et al.   CURRENT MEDICINAL CHEMISTRY

On the Physiological Role of Cytosolic 5’-nucleotidase II (cN-II): Pathological and Therapeutical Implications.

(2013) M. Tozzi et al.   CURRENT MEDICINAL CHEMISTRY

Role of Host Xanthine Oxidase in Infection Due to Enteropathogenic and Shiga-Toxigenic Escherichia coli

(2013) John K. Crane et al.   INFECTION AND IMMUNITY

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of Adenosine Kinase in Rasmussen Encephalitis

(2013) Guoming Luan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish

(2013) Anna Maria Siebel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Regulates Multiple Developmental and Metabolic Pathways of Murine Embryonic Stem Cell Neuronal Differentiation

(2013) Tae Hyuk Kang et al.   PLoS One

Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury

(2013) Daniel Kim et al.   PLoS One

Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients

(2012) Marta G. García et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Novel metabolic aspects related to adenosine deaminase inhibition in a human astrocytoma cell line

(2012) Mercedes Garcia-Gil et al.   NEUROCHEMISTRY INTERNATIONAL

Working memory and the homeostatic control of brain adenosine by adenosine kinase

(2012) P. Singer et al.   NEUROSCIENCE

Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors

(2012) Amit K Mitra et al.   PHARMACOGENOMICS

Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase

(2012) L. Mastrangelo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver Function

(2011) Magnus K. Bjursell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A2Aadenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

(2011) Eduard Gracia et al.   BIOCHEMICAL JOURNAL

Neurological Disorders of Purine and Pyrimidine Metabolism

(2011) Vanna Micheli et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Metabolic Network of Nucleosides in the Brain

(2011) Piero L. Ipata et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy

(2011) Marjolein de Groot et al.   EPILEPSIA

MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch–Nyhan disease?

(2011) Ghiabe-Henri Guibinga et al.   HUMAN MOLECULAR GENETICS

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice

(2011) Hai-Ying Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5′-Nucleotidase II

(2011) Karin Walldén et al.   JOURNAL OF MOLECULAR BIOLOGY

Impaired P2X and P2Y receptor-mediated signaling in HPRT-deficient B103 neuroblastoma cells

(2011) Miriam Erdorf et al.   NEUROSCIENCE LETTERS

Is there anything good in uric acid?

(2011) B. Alvarez-Lario et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Uric Acid and Chronic Kidney Disease: New Understanding of an Old Problem

(2011) Duk-Hee Kang et al.   SEMINARS IN NEPHROLOGY

Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project

(2010) T. Bjorge et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Molecular mechanisms of nucleoside recycling in the brain

(2010) Piero Luigi Ipata et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Uric acid transport and disease

(2010) Alexander So et al.   JOURNAL OF CLINICAL INVESTIGATION

Uric Acid and Hypertension: Cause or Effect?

(2010) Marilda Mazzali et al.   Current Rheumatology Reports

Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus

(2009) Xianying Amy Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling

(2009) Francisco Ciruela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis

(2009) I. Ceballos-Picot et al.   HUMAN MOLECULAR GENETICS

Low uric acid levels in serum of patients with ALS: Further evidence for oxidative stress?

(2009) D. Keizman et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Focal cortical dysplasia type II: biological features and clinical perspectives

(2009) Sanjay M Sisodiya et al.   LANCET NEUROLOGY

Autosomal recessive spastic paraplegia (SPG45) with mental retardation maps to 10q24.3–q25.1

(2009) Umut Dursun et al.   NEUROGENETICS

Cognitive and behavioral abnormalities in children after hematopoietic stem cell transplantation for severe congenital immunodeficiencies

(2008) P. Titman et al.   BLOOD

Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase

(2008) Tomoko Nishino et al.   FEBS Journal

Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice

(2008) Tianfu Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Human adenosine deaminase as an allosteric modulator of human A1adenosine receptor: abolishment of negative cooperativity for [3H](R)-pia binding to the caudate nucleus

(2008) Eduard Gracia et al.   JOURNAL OF NEUROCHEMISTRY

Is ZMP the toxic metabolite in Lesch–Nyhan disease?

(2008) José M. López   MEDICAL HYPOTHESES

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES

Adenosine as a neuromodulator in neurological diseases

(2007) D BOISON   CURRENT OPINION IN PHARMACOLOGY

The role of CD26/dipeptidyl peptidase IV in cancer

(2007) Pamela et al.   Frontiers in Bioscience-Landmark

Abnormal Purine and Pyrimidine Nucleotide Content in Primary Astroglia Cultures from Hypoxanthine-Guanine Phosphoribosyltransferase-Deficient Transgenic Mice

(2003) Dori Pelled et al.   JOURNAL OF NEUROCHEMISTRY