Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
Authors
Keywords
-
Journal
GLIA
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2018-12-24
DOI
10.1002/glia.23568
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- HIV replication is associated to inflammasomes activation, IL-1β, IL-18 and caspase-1 expression in GALT and peripheral blood
- (2018) Manuel Gerónimo Feria et al. PLoS One
- Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs
- (2018) Amy E. Baxter et al. Retrovirology
- Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells
- (2018) Monica Golumbeanu et al. Cell Reports
- The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery
- (2018) Alessandra Bandera et al. Frontiers in Immunology
- Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4 + T Cells Permissive for Latent HIV-1 Infection
- (2017) Liang Shan et al. IMMUNITY
- Autophagy limits activation of the inflammasomes
- (2017) Michihiro Takahama et al. IMMUNOLOGICAL REVIEWS
- HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation
- (2017) Ernest T. Chivero et al. JOURNAL OF NEUROSCIENCE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Autophagy Receptors and Neurodegenerative Diseases
- (2017) Zhiqiang Deng et al. TRENDS IN CELL BIOLOGY
- Neurological Complications of HIV Infection
- (2017) Shelli Farhadian et al. Current Infectious Disease Reports
- NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
- (2016) Zhenyu Zhong et al. CELL
- Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment
- (2016) Mojtaba Golpich et al. CNS Neuroscience & Therapeutics
- Fate of microglia during HIV-1 infection: From activation to senescence?
- (2016) Natalie C. Chen et al. GLIA
- Prevalence and Correlates of Persistent HIV-1 RNA in Cerebrospinal Fluid During Antiretroviral Therapy
- (2016) Albert M. Anderson et al. JOURNAL OF INFECTIOUS DISEASES
- Development and characterization of a human microglia cell model of HIV-1 infection
- (2016) Pratima Rawat et al. JOURNAL OF NEUROVIROLOGY
- The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
- (2016) Marina Saresella et al. Molecular Neurodegeneration
- Antiretroviral Therapy for the Prevention of HIV-1 Transmission
- (2016) Myron S. Cohen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment
- (2016) Arvid Edén et al. PLoS One
- Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
- (2016) Benjamin Richter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
- (2015) Jin-Mi Heo et al. MOLECULAR CELL
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Mitochondria: diversity in the regulation of the NLRP3 inflammasome
- (2015) Prajwal Gurung et al. TRENDS IN MOLECULAR MEDICINE
- Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo
- (2015) Ping Yang et al. Scientific Reports
- MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
- (2014) Xiaojie Zhang et al. Autophagy
- Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation
- (2014) Xin Cai et al. CELL
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection
- (2014) Majid Sakhi Jabir et al. Cell Host & Microbe
- Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study
- (2014) R. K. Heaton et al. CLINICAL INFECTIOUS DISEASES
- HIV-1 Infection Induces Interleukin-1β Production via TLR8 Protein-dependent and NLRP3 Inflammasome Mechanisms in Human Monocytes
- (2014) Haitao Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
- (2014) Bernardo S Franklin et al. NATURE IMMUNOLOGY
- Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons
- (2014) C. Teodorof et al. NEUROBIOLOGY OF DISEASE
- Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy
- (2014) J. Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS
- (2014) John G Walsh et al. Retrovirology
- HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon
- (2014) Michael A. Chattergoon et al. PLoS Pathogens
- Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
- (2013) Sovan Sarkar BIOCHEMICAL SOCIETY TRANSACTIONS
- Monocyte/macrophages and their role in HIV neuropathogenesis
- (2013) Tricia H. Burdo et al. IMMUNOLOGICAL REVIEWS
- Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice
- (2013) Jing Du et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
- (2013) Takuma Misawa et al. NATURE IMMUNOLOGY
- Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
- (2012) Michael Lazarou et al. DEVELOPMENTAL CELL
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
- (2012) Kenichi Shimada et al. IMMUNITY
- NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223
- (2012) F. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1 Production
- (2012) M. Haneklaus et al. JOURNAL OF IMMUNOLOGY
- A novel in vitro human microglia model: Characterization of human monocyte-derived microglia
- (2012) Samar Etemad et al. JOURNAL OF NEUROSCIENCE METHODS
- Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
- (2012) Chong-Shan Shi et al. NATURE IMMUNOLOGY
- Toll-Like Receptor 8 Ligands Activate a Vitamin D Mediated Autophagic Response that Inhibits Human Immunodeficiency Virus Type 1
- (2012) Grant R. Campbell et al. PLoS Pathogens
- Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells
- (2011) T. Weichhart et al. BLOOD
- Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
- (2011) Nicolas Dupont et al. EMBO JOURNAL
- The NLRP3 Inflammasome Detects Encephalomyocarditis Virus and Vesicular Stomatitis Virus Infection
- (2011) J. V. Rajan et al. JOURNAL OF VIROLOGY
- p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
- (2010) Derek Narendra et al. Autophagy
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
- (2010) Noriyuki Matsuda et al. JOURNAL OF CELL BIOLOGY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- Influenza virus activates inflammasomes via its intracellular M2 ion channel
- (2010) Takeshi Ichinohe et al. NATURE IMMUNOLOGY
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
- (2010) Kiichi Nakahira et al. NATURE IMMUNOLOGY
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Astrocytes: biology and pathology
- (2009) Michael V. Sofroniew et al. ACTA NEUROPATHOLOGICA
- Pyroptosis: host cell death and inflammation
- (2009) Tessa Bergsbaken et al. NATURE REVIEWS MICROBIOLOGY
- Toll-like receptors control autophagy
- (2008) Mónica A Delgado et al. EMBO JOURNAL
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
- (2008) Tatsuya Saitoh et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started