M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses

(2016) D Christensen et al.   Mucosal Immunology

Universal influenza vaccines: Shifting to better vaccines

(2016) Francesco Berlanda Scorza et al.   VACCINE

Influenza Vaccines: Challenges and Solutions

(2015) Katherine Houser et al.   Cell Host & Microbe

Effector T cell differentiation: are master regulators of effector T cells still the masters?

(2015) Chao Wang et al.   CURRENT OPINION IN IMMUNOLOGY

Current and next generation influenza vaccines: Formulation and production strategies

(2015) Peter C. Soema et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Universal influenza vaccines, science fiction or soon reality?

(2015) Rory D de Vries et al.   Expert Review of Vaccines

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody

(2015) Ki Joon Cho et al.   JOURNAL OF VIROLOGY

Structure of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus in Complex with a Protective Monoclonal Antibody

(2015) Ki Joon Cho et al.   JOURNAL OF VIROLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

(2015) G. Stary et al.   SCIENCE

Neutrophil trails guide influenza-specific CD8+ T cells in the airways

(2015) K. Lim et al.   SCIENCE

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Virus-specific T cells as correlate of (cross-)protective immunity against influenza

(2015) Arwen F. Altenburg et al.   VACCINE

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus

(2015) Louis M. Schwartzman et al.   mBio

An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus

(2015) Ho-Chuen Leung et al.   Emerging Microbes & Infections

Memory T Follicular Helper CD4 T Cells

(2015) J. Scott Hale et al.   Frontiers in Immunology

A GFP Expressing Influenza A Virus to Report In Vivo Tropism and Protection by a Matrix Protein 2 Ectodomain-Specific Monoclonal Antibody

(2015) Sarah De Baets et al.   PLoS One

IL-21R Signaling Suppresses IL-17+ Gamma Delta T Cell Responses and Production of IL-17 Related Cytokines in the Lung at Steady State and After Influenza A Virus Infection

(2015) Emily K. Moser et al.   PLoS One

Mucosal Immunization with a Candidate Universal Influenza Vaccine Reduces Virus Transmission in a Mouse Model

(2014) G. E. Price et al.   JOURNAL OF VIROLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Intravascular staining for discrimination of vascular and tissue leukocytes

(2014) Kristin G Anderson et al.   Nature Protocols

IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4+ T cells for heterosubtypic protection

(2014) S. A. Valkenburg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell mediated immunity to influenza: mechanisms of viral control

(2014) Nicole L. La Gruta et al.   TRENDS IN IMMUNOLOGY

Intraepithelial T-Cell Cytotoxicity, Induced Bronchus-Associated Lymphoid Tissue, and Proliferation of Pneumocytes in Experimental Mouse Models of Influenza

(2014) Stewart Sell et al.   VIRAL IMMUNOLOGY

Intranasal Vaccination Promotes Detrimental Th17-Mediated Immunity against Influenza Infection

(2014) Asher Maroof et al.   PLoS Pathogens

Mucosal Pre-Exposure to Th17-Inducing Adjuvants Exacerbates Pathology after Influenza Infection

(2013) Radha Gopal et al.   AMERICAN JOURNAL OF PATHOLOGY

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

(2013) K. Kai McKinstry et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Multipronged CD4+T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus

(2013) Tara M. Strutt et al.   IMMUNOLOGICAL REVIEWS

Development of universal influenza vaccines based on influenza virus M and NP genes

(2013) M. Zheng et al.   INFECTION

Recombinant IgA Is Sufficient To Prevent Influenza Virus Transmission in Guinea Pigs

(2013) C. W. Seibert et al.   JOURNAL OF VIROLOGY

A Novel Subnucleocapsid Nanoplatform for Mucosal Vaccination against Influenza Virus That Targets the Ectodomain of Matrix Protein 2

(2013) P.-L. Herve et al.   JOURNAL OF VIROLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

A common solution to group 2 influenza virus neutralization

(2013) R. H. E. Friesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal immunity and nasal influenza vaccination

(2012) Markus A Rose et al.   Expert Review of Vaccines

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms

(2012) K. Kai McKinstry et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection

(2012) H. Hamada et al.   JOURNAL OF IMMUNOLOGY

Localized Mucosal Response to Intranasal Live Attenuated Influenza Vaccine in Adults

(2012) Maria Ines Barría et al.   JOURNAL OF INFECTIOUS DISEASES

Type I Interferon Induction during Influenza Virus Infection Increases Susceptibility to Secondary Streptococcus pneumoniae Infection by Negative Regulation of    T Cells

(2012) W. Li et al.   JOURNAL OF VIROLOGY

Natural and long-lasting cellular immune responses against influenza in the M2e-immune host

(2012) M Schotsaert et al.   Mucosal Immunology

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors

(2012) T. M. Strutt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines

(2011) Marine L. B. Hillaire et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A Unique Role of the Cholera Toxin A1-DD Adjuvant for Long-Term Plasma and Memory B Cell Development

(2011) M. Bemark et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Transcriptional Control of Rapid Recall by Memory CD4 T Cells

(2011) W. Lai et al.   JOURNAL OF IMMUNOLOGY

Memory CD4 T Cells That Express CXCR5 Provide Accelerated Help to B Cells

(2011) M. K. L. MacLeod et al.   JOURNAL OF IMMUNOLOGY

Hallmarks of CD4 T cell immunity against influenza

(2011) K. K. McKinstry et al.   JOURNAL OF INTERNAL MEDICINE

A Human Multi-Epitope Recombinant Vaccinia Virus as a Universal T Cell Vaccine Candidate against Influenza Virus

(2011) Alan G. Goodman et al.   PLoS One

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus

(2011) Dubravka Grdic Eliasson et al.   VACCINE

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

(2010) K. El Bakkouri et al.   JOURNAL OF IMMUNOLOGY

Influenza A Inhibits Th17-Mediated Host Defense against Bacterial Pneumonia in Mice

(2010) A. Kudva et al.   JOURNAL OF IMMUNOLOGY

Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine

(2010) Gary J Nabel et al.   NATURE MEDICINE

Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant

(2010) Zhiwei Sui et al.   VACCINE

Genetic control of immune responses to influenza A matrix 2 protein (M2)

(2010) Julia A. Misplon et al.   VACCINE

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

(2009) Michael Schotsaert et al.   Expert Review of Vaccines

M2e-based universal influenza A vaccine

(2009) Walter Fiers et al.   VACCINE

Antibodies and CD4+ T-cells mediate cross-protection against H5N1 influenza virus infection in mice after vaccination with a low pathogenic H5N2 strain

(2008) Karoline Droebner et al.   VACCINE

CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine

(2008) Dubravka Grdic Eliasson et al.   VACCINE