Targeting SOX2 in anticancer therapy

SOX2-mediated upregulation of CD24 promotes adaptive resistance towards targeted therapy in melanoma

(2018) Laura Hüser et al.   INTERNATIONAL JOURNAL OF CANCER

XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells

(2018) Jiao Ji et al.   Theranostics

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth

(2017) Bo Ram Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

(2017) Kuancan Liu et al.   Molecular Cancer

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

(2017) Ping Mu et al.   SCIENCE

Cancer stem cells and differentiation therapy

(2017) Xiong Jin et al.   TUMOR BIOLOGY

Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma

(2017) Etsuko Yokota et al.   Oncotarget

Modulation of SOX2 expression delineates an end-point for paclitaxel-effectiveness in breast cancer stem cells

(2017) Pritha Mukherjee et al.   Scientific Reports

Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response

(2017) Mathias Bernhardt et al.   Stem Cell Reports

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

(2016) Ida V. Lundberg et al.   BMC CANCER

Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity

(2016) Sheng-Chieh Lin et al.   CANCER RESEARCH

mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

(2016) Laura Garros-Regulez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathway

(2016) Chongmin Ren et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival

(2016) Silvia Pietrobono et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sox2, a stemness gene, regulates tumor-initiating and drug-resistant properties in CD133-positive glioblastoma stem cells

(2016) Wen-Shin Song et al.   Journal of the Chinese Medical Association

TGF-βinduces SOX2 expression in a time-dependent manner in human melanoma cells

(2016) Kasia Weina et al.   Pigment Cell & Melanoma Research

The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1

(2015) DANIJELA DRAKULIC et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

SOX2, a predictor of survival in gastric cancer, inhibits cell proliferation and metastasis by regulating PTEN

(2015) Simeng Wang et al.   CANCER LETTERS

Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells

(2015) Ning Yang et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Overexpression of SOX2 is involved in paclitaxel resistance of ovarian cancer via the PI3K/Akt pathway

(2015) Yang Li et al.   TUMOR BIOLOGY

Rapamycin inhibited the function of lung CSCs via SOX2

(2015) Li-Xia Xie et al.   TUMOR BIOLOGY

miR-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular carcinoma cells partially by targeting Sox2

(2015) Chunfang Zhao et al.   Human Cell

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

(2015) Namrata Bora-Singhal et al.   NEOPLASIA

SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma

(2014) S H Lee et al.   BRITISH JOURNAL OF CANCER

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

(2014) Robert J. Vanner et al.   CANCER CELL

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

(2014) Verline Justilien et al.   CANCER CELL

Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

(2014) Rebecca Favaro et al.   CANCER RESEARCH

High Expression of SOX2 and OCT4 Indicates Radiation Resistance and an Independent Negative Prognosis in Cervical Squamous Cell Carcinoma

(2014) Liangfang Shen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines

(2014) Irem Dogan et al.   LUNG CANCER

Sox2 is involved in paclitaxel resistance of the prostate cancer cell line PC-3 via the PI3K/Akt pathway

(2014) DONG LI et al.   Molecular Medicine Reports

SOX2 promotes the migration and invasion of laryngeal cancer cells by induction of MMP-2 via the PI3K/Akt/mTOR pathway

(2014) NING YANG et al.   ONCOLOGY REPORTS

SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma

(2013) P. M. Bareiss et al.   CANCER RESEARCH

The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells

(2013) Katharina Hütz et al.   CARCINOGENESIS

SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells

(2013) Si Chen et al.   CARCINOGENESIS

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

Sox2 promotes tamoxifen resistance in breast cancer cells

(2013) Marco Piva et al.   EMBO Molecular Medicine

SOX2 Targets Fibronectin 1 to Promote Cell Migration and Invasion in Ovarian Cancer: New Molecular Leads for Therapeutic Intervention

(2013) Xiaoyan Lou et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung Cancer

(2013) Yu-Ting Chou et al.   STEM CELLS

Pluripotent Stem Cell Protein Sox2 Confers Sensitivity to LSD1 Inhibition in Cancer Cells

(2013) Xiaoming Zhang et al.   Cell Reports

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

(2013) M Herreros-Villanueva et al.   Oncogenesis

The SOX family of genes in cancer development: biological relevance and opportunities for therapy

(2012) Sandra D Castillo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sex-determining region Y-box 2 expression predicts poor prognosis in human ovarian carcinoma

(2012) Jing Zhang et al.   HUMAN PATHOLOGY

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

(2012) Sabine Stolzenburg et al.   NUCLEIC ACIDS RESEARCH

Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway

(2012) Jian Yang et al.   STEM CELLS

ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*-Mediated Suppression of SOX2

(2011) H.-M. Jeon et al.   CANCER RESEARCH

Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties

(2011) J. Wang et al.   CANCER RESEARCH

Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest

(2011) I. Adameyko et al.   DEVELOPMENT

SOX2 contributes to melanoma cell invasion

(2011) Sasha D Girouard et al.   LABORATORY INVESTIGATION

SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer

(2011) Theresia Wilbertz et al.   MODERN PATHOLOGY

SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell

(2011) X. Jia et al.   Journal of Molecular Cell Biology

SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma

(2010) Yasuyuki Gen et al.   CANCER GENETICS AND CYTOGENETICS

Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy

(2009) Susumu Saigusa et al.   ANNALS OF SURGICAL ONCOLOGY

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

All purpose Sox: The many roles of Sox proteins in gene expression

(2009) Michael Wegner   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells

(2009) J. Utikal et al.   JOURNAL OF CELL SCIENCE

SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis

(2008) T Otsubo et al.   BRITISH JOURNAL OF CANCER

An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells

(2008) Jonghwan Kim et al.   CELL

Reprogramming of Neural Progenitor Cells into Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 Expression

(2008) Sarah Eminli et al.   STEM CELLS

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS