mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

Increased gene dosage ofInk4/Arfandp53delays age-associated central nervous system functional decline

(2015) Estefania Carrasco-Garcia et al.   AGING CELL

Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum

(2015) Keng Ioi Vong et al.   Molecular Brain

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

(2014) Robert J. Vanner et al.   CANCER CELL

Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

(2014) Rebecca Favaro et al.   CANCER RESEARCH

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

The mTOR signaling pathway as a treatment target for intracranial neoplasms

(2014) D. Pachow et al.   NEURO-ONCOLOGY

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Neural-Competent Cells of Adult Human Dermis Belong to the Schwann Lineage

(2014) Usue Etxaniz et al.   Stem Cell Reports

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency

(2013) Shuo Wang et al.   Cell Stem Cell

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes

(2013) S. A. Hoffmann et al.   DEVELOPMENT

Sox2 promotes tamoxifen resistance in breast cancer cells

(2013) Marco Piva et al.   EMBO Molecular Medicine

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion

(2013) Guocan Wang et al.   NATURE GENETICS

MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells

(2013) S. B. Rani et al.   NEURO-ONCOLOGY

Therapeutic Strategies Targeting Glioblastoma Stem Cells

(2013) Estefania Carrasco-Garcia et al.   Recent Patents on Anti-Cancer Drug Discovery

Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC

(2012) Fredrik J. Swartling et al.   CANCER CELL

Oncogenicity of the Developmental Transcription Factor Sox9

(2012) A. Matheu et al.   CANCER RESEARCH

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

(2012) Dong Wook Han et al.   Cell Stem Cell

Oncogenic role of SOX9 expression in human malignant glioma

(2012) Liang Wang et al.   MEDICAL ONCOLOGY

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis

(2011) Xuefeng Fang et al.   BMC GENOMICS

Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway

(2011) Eva Maria Galan-Moya et al.   EMBO REPORTS

Sequentially acting Sox transcription factors in neural lineage development

(2011) M. Bergsland et al.   GENES & DEVELOPMENT

Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile

(2011) Daniel Hägerstrand et al.   NEURO-ONCOLOGY

Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas

(2011) Marta M. Alonso et al.   PLoS One

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

SOX9 induces and maintains neural stem cells

(2010) Charlotte E Scott et al.   NATURE NEUROSCIENCE

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

(2009) Rebecca Favaro et al.   NATURE NEUROSCIENCE

Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87

(2008) Shi-cang Yu et al.   CANCER LETTERS

Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller Glial cell development

(2008) Ross A. Poché et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Reprogramming of Neural Progenitor Cells into Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 Expression

(2008) Sarah Eminli et al.   STEM CELLS

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS