Article
Gastroenterology & Hepatology
Ting Liu, Xiao-Li Xie, Xue Zhou, Sheng-Xiong Chen, Yi-Jun Wang, Lin-Ping Shi, Shu-Jia Chen, Yong-Juan Wang, Shu-Ling Wang, Jiu-Na Zhang, Shi-Ying Dou, Xiao-Yu Jiang, Ruo-Lin Cui, Hui-Qing Jiang
Summary: YB-1, overexpressed in HCC tissues, enhances sorafenib resistance through the PI3K/Akt pathway. Knockdown of YB-1 can improve the efficacy of sorafenib in vivo. The interaction between YB-1 and key proteins of the PI3K/Akt pathway contributes to sorafenib resistance in HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Cell Biology
Peng Zhang, Liang Chen, Fenfang Zhou, Zhiwen He, Gang Wang, Yongwen Luo
Summary: Prostate cancer (PCa) is a common male malignancy with unclear progression mechanisms. This study found that NRP1, highly expressed in PCa, was associated with poor prognosis in PCa patients. Functionally, NRP1 depletion inhibited PCa cell proliferation and migration, while NRP1 overexpression promoted these processes. Mechanistically, NRP1 was regulated by HIF1 alpha and interacted with EGFR, leading to EGFR phosphorylation and activation of the AKT signaling pathway, promoting PCa progression. Additionally, the NRP1 inhibitor EG01377 inactivated the EGFR/AKT signaling axis and suppressed PCa progression.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Meizhu Zheng, Minghui Chen, Wenli Wang, Mi Zhou, Chunming Liu, Yajun Fan, Dongfang Shi
Summary: Rhy has been shown to have a neuroprotective effect by activating the PI3K/Akt signaling pathway, improving cell viability, inhibiting apoptosis, and reducing levels of LDH, [Ca2+]i, and ROS in models of Parkinson's disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Abril Marcela Herrera-Solorio, Irlanda Peralta-Arrieta, Leonel Armas Lopez, Nallely Hernandez-Cigala, Criselda Mendoza Milla, Blanca Ortiz Quintero, Rodrigo Catalan Cardenas, Priscila Pineda Villegas, Evelyn Rodriguez Villanueva, Cynthia G. Trejo Iriarte, Joaquin Zuniga, Oscar Arrieta, Federico Avila-Moreno
Summary: This study demonstrates that LncRNA SOX2-OT plays a role in regulating a coordinated resistance mechanism, promoting poor prognosis and human lung malignancy through genetic, epigenetic, and post-translational mechanisms, impacting the effectiveness of TKI and platinum-based therapy in lung cancer.
MOLECULAR ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fang Zhu, Jujia Zheng, Fang Xu, Yiyuan Xi, Jun Chen, Xiangwei Xu
Summary: The study found that RSV can alleviate UC symptoms by mediating intestinal microflora homeostasis, suppressing the activation of the PI3K/Akt pathway, and reducing the expression of the VEGFA gene.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Abdulmelik Aytatli, Neslisah Barlak, Fatma Sanli, Hasan Onur Caglar, Betul Gundogdu, Arzu Tatar, Michael Ittmann, Omer Faruk Karatas
Summary: The study showed that the FGFR/Akt/SOX2 axis was overexpressed in tumor tissues compared to normal tissues, and AZD4547 effectively suppressed the expression of FGFR and its downstream targets in recombinant FGF2 treated HNSCC cells. Additionally, AZD4547 reduced the viability, migration, and colony forming capacity of HNSCC cells, with a potentiated impact when co-treated with taxol. This suggests that AZD4547 may be a promising therapeutic agent to overcome taxol-resistance in HNSCC.
Article
Multidisciplinary Sciences
Jiasheng Yuan, Yuehui Liu, Juan Yu, Meina Dai, Yu Zhu, Youwei Bao, Haisen Peng, Ke Liu, Xinhua Zhu
Summary: In this study, conditional knockout of the bone marrow CCR3 gene was found to reduce eosinophilic inflammation and the Th2 immune response in allergic rhinitis mice, possibly through inhibition of the PI3K/AKT pathway.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Xi-juan Zhao, Kui Wang, Rong Li, Yang Lu, Pan Lu, Pei Fan, Yu-ying Lv, Xin-lin Chen, Hao-zheng Yuan
Summary: This study aimed to investigate the action of simvastatin on cortical neurons exposed to isoflurane and establish the mechanism of this action. It was found that simvastatin pretreatment protected neurons from isoflurane-induced neurotoxicity in vitro, and the phosphoinositide 3-kinase (PI3K)/Akt pathway mediated this effect.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Tianli Zhang, Mengmeng Liu, Qing Liu, Gary Guishan Xiao
Summary: Wogonin can enhance the sensitivity of pancreatic cancer cells to gemcitabine chemotherapy, possibly by promoting apoptosis through inhibiting the Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhoupeng Li, Fang Wang, Yongsheng Liu, Dongshen Zhai, Xiaoxiao Zhang, Qikang Ying, Min Jia, Xiaoyan Xue, Jingru Meng, Jing Li, Xingan Wu, Mingkai Li
Summary: A study found that the coumarin derivative N6 shows strong inhibitory effects on HTNV, and early administration can effectively inhibit virus replication and production. Molecular docking results show that N6 interacts with key amino acid residues, and the treatment can inhibit the expression of specific proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chao Dong, Jiao Wu, Yin Chen, Jianyun Nie, Ceshi Chen
Summary: Hyperactivation of the PI3K/AKT/mTOR pathway is associated with drug resistance and cancer progression in breast cancer patients. Current research is focusing on developing drugs targeting this pathway to overcome acquired resistance to standard therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li-ying Zhang, Jia-ying Yu, Yan-long Leng, Ran-ran Zhu, Hong-xian Liu, Xin-yu Wang, Ting-ting Yang, Yi-ning Guo, Jing-ling Tang, Xin-chen Zhang
Summary: The study identified miR-181c as downregulated in PTX-resistant ovarian cancer cells and tissues, which induced apoptosis and inhibited the PI3K/Akt pathway by directly targeting GRP78. Overexpression of miR-181c sensitized resistant ovarian cancer to PTX, suggesting a potential therapeutic strategy.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth E. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz, Donald J. Vander Griend
Summary: This study investigated the impact of SOX2 expression on patient outcomes and its function within prostate cancer cells. The results revealed that SOX2 expression promotes metastatic progression and therapy resistance in prostate cancer, and affects the metabolic pathways and metabolites of cancer cells. These findings contribute to a better understanding of the role of SOX2 in prostate cancer and suggest its potential as a biomarker and pharmacologic target in clinical settings.
Article
Oncology
Anthony Williams, Lisa Gutgesell, Larischa de Wet, Phillip Selman, Arunangsu Dey, Mahati Avineni, Isha Kapoor, Megan Mendez, Ryan Brown, Sophia Lamperis, Chuck Blajszczak, Eric Bueter, Steven Kregel, Donald J. Vander Griend, Russell Z. Szmulewitz
Summary: The development of drug resistance in prostate cancer is a challenge, and SOX2 overexpression has been identified as a factor in this resistance. The NR3C1 gene, encoding glucocorticoid receptor, is a target of SOX2 and positively regulates its expression. In addition, SOX2-positive PC cells are insensitive to NHRSI treatment, and the inhibition of WEE1 kinase, along with ARSI or GR modulation, can improve the efficacy of NHRSIs in SOX2-positive PC.
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Oncology
Jiebing Tang, Yuanyuan Chen, Rongjun Cui, Dong Li, Lijie Xiao, Ping Lin, Yandan Du, Hui Sun, Xiaoguang Yu, Xiulan Zheng
MOLECULAR MEDICINE REPORTS
(2015)
Article
Oncology
Dong Li, Zheng-Kai Yang, Jing-Yi Bu, Chun-Yan Xu, Hui Sun, Jie-Bing Tang, Ping Lin, Wen Cheng, Ning Huang, Rong-Jun Cui, Xiao-Guang Yu, Xiu-Lan Zheng
Article
Oncology
Jiebing Tang, Lijie Xiao, Rongjun Cui, Dong Li, Xiulan Zheng, Lijuan Zhu, Hui Sun, Yujia Pan, Yandan Du, Xiaoguang Yu
Article
Multidisciplinary Sciences
Liang Guo, Chunyan Xu, Dong Li, Xiulan Zheng, Jiebing Tang, Jingyi Bu, Hui Sun, Zhengkai Yang, Wenjing Sun, Xiaoguang Yu
Article
Oncology
Dong Li, Hui Sun, Wen-jing Sun, Hong-bo Bao, Shu-han Si, Jia-lin Fan, Ping Lin, Rong-jun Cui, Yu-jia Pan, Si-min Wen, Xiu-lan Zheng, Xiao-guang Yu
Article
Oncology
Ping Lin, Lijuan Zhu, Wenjing Sun, Zhengkai Yang, Hui Sun, Dong Li, Rongjun Cui, Xiulan Zheng, Xiaoguang Yu
Article
Cell Biology
F. Lin, P. Lin, D. Zhao, Y. Chen, L. Xiao, W. Qin, D. Li, H. Chen, B. Zhao, H. Zou, X. Zheng, X. Yu
CELL PROLIFERATION
(2012)
Article
Oncology
Li-Jie Xiao, Yuan-Yuan Chen, Ping Lin, Hai-Feng Zou, Feng Lin, Li-Nan Zhao, Dong Li, Liang Guo, Jie-Bing Tang, Xiu-Lan Zheng, Xiao-Guang Yu
INTERNATIONAL JOURNAL OF ONCOLOGY
(2012)
Article
Oncology
Wei Qin, Yujia Pan, Xiulan Zheng, Dong Li, Jingyi Bu, Chunyan Xu, Jiebing Tang, Rongjun Cui, Ping Lin, Xiaoguang Yu
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Oncology
Dong Li, Chun-Yan Xu, Rong-Jun Cui, Jie-Bing Tang, Hui Sun, Zheng-Kai Yang, Jing-Yi Bu, Ping Lin, Ning Huang, Yan-Dan Du, Xiao-Guang Yu
MOLECULAR MEDICINE REPORTS
(2015)
Article
Biochemistry & Molecular Biology
Dong Li, Fan Wu, Shuo Zhou, Xiao-Jun Huang, Hsiang-Ying Lee
Summary: In this study, the higher-order chromatin structure in primary human erythroblasts was analyzed. The results showed that heterochromatin regions undergo significant compression, with relocalization of H3K9me3 markers and formation of long-range interactions. Approximately 58% of the topologically associating domain boundaries were disrupted, while certain TADs enriched for markers of active transcription state and erythroid master regulators were selectively maintained. Furthermore, GATA1 was found to be involved in safeguarding selected essential chromatin domains during terminal erythropoiesis.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dong Li, Xin-Ying Zhao, Shuo Zhou, Qi Hu, Fan Wu, Hsiang-Ying Lee
Summary: Mammalian erythroid development consists of three stages: hematopoietic stem and progenitor cell (HSPC), erythroid progenitor (Ery-Pro), and erythroid precursor (Ery-Pre). In this study, chromatin landscape analysis was conducted in primary human erythroid culture and revealed dynamic changes in enhancers and transcription factors (TFs) during different stages. The erythropoiesis master TF, GATA1, was found to play a crucial role in rewiring enhancer connectome and promoting erythroid gene transcription output. Knocking down GATA1 led to cellular state reversion and extended the progenitor state. This study provides mechanistic insights into chromatin rearrangements during erythroid development.
NUCLEIC ACIDS RESEARCH
(2023)