Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome

A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity

(2017) Katrina Hurst et al.   HIPPOCAMPUS

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

(2017) Lyndsey L. Anderson et al.   Scientific Reports

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

(2016) Reesha R. Patel et al.   BRAIN

Trends in registered medical marijuana participation across 13 US states and District of Columbia

(2016) Brian J. Fairman   DRUG AND ALCOHOL DEPENDENCE

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

(2016) Orrin Devinsky et al.   LANCET NEUROLOGY

Causal Evidence for the Role of Specific GABAergic Interneuron Types in Entorhinal Recruitment of Dentate Granule Cells

(2016) Cheng-Ta Lee et al.   Scientific Reports

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

(2016) Nicole A. Hawkins et al.   PLoS Genetics

Dissecting the phenotypes of Dravet syndrome by gene deletion

(2015) Moran Rubinstein et al.   BRAIN

Autism and behavior in adult patients with Dravet syndrome (DS)

(2015) J.J.L. Berkvens et al.   EPILEPSY & BEHAVIOR

Cannabinoids for Medical Use

(2015) Penny F. Whiting et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In vivoevaluation of the dentate gate theory in epilepsy

(2015) Esther Krook-Magnuson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome

(2015) Moran Rubinstein et al.   NEUROBIOLOGY OF DISEASE

Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome

(2015) Franck Kalume et al.   NEUROBIOLOGY OF DISEASE

Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model

(2015) Alex Straiker et al.   PHARMACOLOGICAL RESEARCH

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

(2014) Orrin Devinsky et al.   EPILEPSIA

The impact of intolerance of uncertainty, worry and irritability on quality of life in persons with epilepsy: Irritability as mediator

(2014) Usha Barahmand et al.   EPILEPSY RESEARCH

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice

(2014) Akshitkumar M. Mistry et al.   NEUROBIOLOGY OF DISEASE

Enhancement of Inhibitory Neurotransmission by GABA A Receptors Having α 2,3 -Subunits Ameliorates Behavioral Deficits in a Mouse Model of Autism

(2014) Sung Han et al.   NEURON

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1receptor-independent mechanism

(2013) T D M Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome

(2013) Ikuo Ogiwara et al.   HUMAN MOLECULAR GENETICS

Sudden unexpected death in a mouse model of Dravet syndrome

(2013) Franck Kalume et al.   JOURNAL OF CLINICAL INVESTIGATION

Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses

(2013) S. Sylantyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

(2012) Susumu Ito et al.   NEUROBIOLOGY OF DISEASE

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures

(2012) Nicholas A. Jones et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Dravet syndrome: The long-term outcome

(2011) Pierre Genton et al.   EPILEPSIA

The core Dravet syndrome phenotype

(2011) Charlotte Dravet   EPILEPSIA

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour

(2011) Serena Deiana et al.   PSYCHOPHARMACOLOGY

Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy

(2009) J. C. Oakley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: Literature review

(2009) Katy Gallop et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

(2008) Silvia Mandillo et al.   PHYSIOLOGICAL GENOMICS

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY