Derivation of Specific Neural Populations From Pluripotent Cells for Understanding and Treatment of Spinal Cord Injury

Astrocytes in primary cultures express serine racemase, synthesize d -serine and acquire A1 reactive astrocyte features

(2018) Suyan Li et al.   BIOCHEMICAL PHARMACOLOGY

Effect of hyaluronic acid hydrogels containing astrocyte-derived extracellular matrix and/or V2a interneurons on histologic outcomes following spinal cord injury

(2018) Russell E. Thompson et al.   BIOMATERIALS

Mouse but not zebrafish requires retinoic acid for control of neuromesodermal progenitors and body axis extension

(2018) Marie Berenguer et al.   DEVELOPMENTAL BIOLOGY

Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition

(2018) Zhenghui Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WT1-Expressing Interneurons Regulate Left–Right Alternation during Mammalian Locomotor Activity

(2018) Farhia Haque et al.   JOURNAL OF NEUROSCIENCE

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

(2018) Leonie Asboth et al.   NATURE NEUROSCIENCE

Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control

(2018) Marito Hayashi et al.   NEURON

Origin and Segmental Diversity of Spinal Inhibitory Interneurons

(2018) Lora B. Sweeney et al.   NEURON

Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells

(2018) Sandeep Gupta et al.   Stem Cell Reports

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation

(2017) Lea Ziskind-Conhaim et al.   JOURNAL OF NEUROPHYSIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Differentiation of V2a interneurons from human pluripotent stem cells

(2017) Jessica C. Butts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells

(2017) Matthew J Sternfeld et al.   eLife

Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse

(2017) Vanessa Caldeira et al.   Scientific Reports

Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits

(2016) Jay B. Bikoff et al.   CELL

Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury

(2016) Thomas M. Fandel et al.   Cell Stem Cell

Intrathecal Transplantation of Embryonic Stem Cell-Derived Spinal GABAergic Neural Precursor Cells Attenuates Neuropathic Pain in a Spinal Cord Injury Rat Model

(2016) Insik Hwang et al.   CELL TRANSPLANTATION

Generation of highly enriched V2a interneurons from mouse embryonic stem cells

(2016) Nisha R. Iyer et al.   EXPERIMENTAL NEUROLOGY

Spinal Cord Injury (SCI) 2016 Facts and Figures at a Glance

(2016)   JOURNAL OF SPINAL CORD MEDICINE

Modeling ALS with motor neurons derived from human induced pluripotent stem cells

(2016) Samuel Sances et al.   NATURE NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification

(2016) G. Christopher Tan et al.   Cell Reports

Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells

(2015) Susanne Kleiderman et al.   GLIA

Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

(2015) Elizabeth L. Calder et al.   JOURNAL OF NEUROSCIENCE

Schwann cell transplantation for spinal cord injury repair: its significant therapeutic potential and prospectus

(2015) Haruo Kanno et al.   REVIEWS IN THE NEUROSCIENCES

Concise Review: Reactive Astrocytes and Stem Cells in Spinal Cord Injury: Good Guys or Bad Guys?

(2015) Dunja Lukovic et al.   STEM CELLS

Directed Differentiation of V3 Interneurons from Mouse Embryonic Stem Cells

(2015) Hao Xu et al.   STEM CELLS AND DEVELOPMENT

A puromycin selectable cell line for the enrichment of mouse embryonic stem cell-derived V3 interneurons

(2015) Hao Xu et al.   Stem Cell Research & Therapy

Molecular and cellular development of spinal cord locomotor circuitry

(2015) Daniel C. Lu et al.   Frontiers in Molecular Neuroscience

Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury

(2015) Charles Nicaise   World Journal of Stem Cells

A new method for generating high purity motoneurons from mouse embryonic stem cells

(2014) Dylan A. McCreedy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Generation of V2a Interneurons from Mouse Embryonic Stem Cells

(2014) Chelsea R. Brown et al.   STEM CELLS AND DEVELOPMENT

Functional Subpopulations of V3 Interneurons in the Mature Mouse Spinal Cord

(2013) J. Borowska et al.   JOURNAL OF NEUROSCIENCE

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

(2013) Laurent Roybon et al.   Cell Reports

Irregular Breathing in Mice following Genetic Ablation of V2a Neurons

(2012) S. A. Crone et al.   JOURNAL OF NEUROSCIENCE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Specification of transplantable astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   NATURE BIOTECHNOLOGY

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation

(2010) Mirza Peljto et al.   Cell Stem Cell

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

(2010) Wolfram Tetzlaff et al.   JOURNAL OF NEUROTRAUMA

Transplantation of GABAergic Neurons from ESCs Attenuates Tactile Hypersensitivity Following Spinal Cord Injury

(2010) Dae-Sung Kim et al.   STEM CELLS

Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo

(2010) Lodovica Borghese et al.   STEM CELLS

Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways

(2009) V. Ribes et al.   DEVELOPMENT

Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity

(2009) Susana Ferreira Rocha et al.   DEVELOPMENTAL BIOLOGY

Regulation of mouse embryonic stem cell neural differentiation by retinoic acid

(2009) Mijeong Kim et al.   DEVELOPMENTAL BIOLOGY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

(2009) Grégoire Courtine et al.   NATURE NEUROSCIENCE

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

(2009) P. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code

(2008) Christian Hochstim et al.   CELL

Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1

(2008) Jeremy S. Dasen et al.   CELL

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury

(2007) Gregoire Courtine et al.   NATURE MEDICINE