Article
Cell Biology
Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Ghazal Haghi, Anna Kristyna Franco Flores, Guy Rouleau, Thomas M. Durcan, Stefano Stifani
Summary: Astrocytes play critical roles in neuronal function and survival, and dysfunctions in astrocytes are associated with various nervous system disorders and diseases. Human-induced pluripotent stem cell (iPSC)-based approaches provide valuable tools for studying the involvement of astrocytes in motor neuron degeneration, particularly in amyotrophic lateral sclerosis (ALS).
Review
Cell Biology
Eva Sykova, Dasa Cizkova, Sarka Kubinova
Summary: MSCs, as candidates in regenerative medicine, have shown significant therapeutic potential in animal experiments and clinical studies due to their immunomodulatory, paracrine, and neural stimulation effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Hirotoshi Magota, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Ryo Ukai, Ryo Kiyose, Rie Onodera, Jeffery D. Kocsis, Osamu Honmou
Summary: ALS is a devastating neurodegenerative disease with uncertain pathogenesis, but disruption of BSCB may contribute to motor neuron degeneration. Intravenous infusion of MSCs in SOD1(G93A) ALS rats showed delayed disease progression, preserved BSCB function, and increased expression of neurturin, indicating potential therapeutic targets for ALS treatment.
Review
Biochemistry & Molecular Biology
Belen Proano, Julia Casani-Cubel, Maria Benlloch, Ana Rodriguez-Mateos, Esther Navarro-Illana, Jose Maria Lajara-Romance, Jose Enrique de la Rubia Orti
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no medical cure. Dutasteride, a potential treatment molecule, has shown neuroprotective, antioxidant, and anti-inflammatory effects in ALS.
Article
Clinical Neurology
Christian Lunetta, Andrea Lizio, Corrado Cabona, Francesca Gerardi, Valeria Ada Sansone, Massimo Corbo, Carlo Scialo, Emanuele Angelucci, Francesca Gualandi, Paola Marenco, Giovanni Grillo, Roberto Cairoli, Clara Cesana, Riccardo Saccardi, Mario Giovanni Melazzini, Gianluigi Mancardi, Claudia Caponnetto
Summary: This study aimed to investigate the safety and potential effect of autologous hematopoietic stem cell transplantation (aHSCT) in ALS patients. The results showed that the procedure was well tolerated, but did not significantly modify the disease progression.
JOURNAL OF NEUROLOGY
(2022)
Review
Neurosciences
Stefano Stifani
Summary: Astrocytes play important roles in the nervous system, providing support and participating in neuroinflammation. Research on the pathophysiology of ALS needs to consider the diversity of astrocytes, and using human induced pluripotent stem cells is an effective approach to explore this.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Akiko Yamamuro-Tanabe, Yurika Mukai, Wataru Kojima, Siyuan Zheng, Naoko Matsumoto, Shoho Takada, Mao Mizuhara, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshioka
Summary: Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease characterized by motor neuron degeneration. Inflammatory cytokines and reactive astrocytes, specifically neuropathic cytotoxic (A1) astrocytes, are believed to contribute to the progression of ALS. This study found that the expression of PRDX6, a member of the peroxiredoxin family, was upregulated in astrocytes of ALS mouse models. Transfection of PRDX6 increased the expression of A1 astrocyte markers and inflammatory cytokines. The results suggest that PRDX6 plays an important role in the induction of A1 astrocytes and expression of inflammatory cytokines in ALS.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Jian Zhang, Dongxiao Li, Guofeng Yang, Xiangjian Zhang, Lin Chen, Yingzhen Zhang, Xiaoming Qi, Yi Li, Yansu Guo
Summary: The study found that treatment with oxymatrine (OMT) delayed body weight loss, improved motor performance, and prolonged survival in SOD1-G93A mice. OMT treatment promoted neuronal survival, and neuroprotection effects were achieved by suppressing neuroinflammation in transgenic ALS mice.
Review
Biochemistry & Molecular Biology
Courtney M. Clark, Rosemary M. Clark, Joshua A. Hoyle, Tracey C. Dickson
Summary: NPY has gained interest as a potential neuroprotective agent for neurodegenerative diseases, with evidence suggesting a possible role in ALS pathogenesis. While increased NPY levels correlate with disease progression in ALS, the functional consequences are not fully understood.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Clinical Neurology
M. Khamaysa, M. Lefort, M. Pelegrini-Issac, A. Lackmy-Vallee, A. Preuilh, D. Devos, A. -S. Rolland, C. Desnuelle, M. Chupin, V. Marchand-Pauvert, G. Querin, Pierre-Francois Pradat
Summary: This study aimed to evaluate the predictive value of cervical spinal cord MRI parameters for motor capacity in ALS compared to clinical prognostic factors. Structural MRI measurements were significantly correlated with the ALSFRS-R score and its sub-scores. Multiple linear regression models combining spinal multimodal MRI and clinical factors could predict motor capacity in ALS.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Oumayma Aousji, Simone Feldengut, Stefano Antonucci, Michael Schoen, Tobias M. Boeckers, Jakob Matschke, Christian Mawrin, Albert C. Ludolph, Kelly Del Tredici, Francesco Roselli, Heiko Braak
Summary: This study investigated the loss of synapses associated with amyotrophic lateral sclerosis (ALS) and found that ALS patients exhibited a substantial loss of synapses in the ventral horn of lumbar and cervical spinal cord. The extent of synaptic loss was correlated with disease duration, clinical site of onset, and loss of α-motoneurons, but not with the fraction of pTDP-43-immunopositive α-motoneurons. These findings validate the synaptic pathology observed in other models and suggest the critical role of pathogenic pathways in the spinal microenvironment in the progressive disassembly of local synaptic connectivity.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Panayiota Petrou, Ibrahim Kassis, Nour Eddine Yaghmour, Ariel Ginzberg, Dimitrios Karussis
Summary: The results of the study indicated that repeated intrathecal injections of autologous MSC in ALS patients were safe and showed medium-term clinical benefits, which were related to the intervals between cell administrations. Larger studies are needed to confirm these observations.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Review
Clinical Neurology
Daisuke Ito, Satoru Morimoto, Shinichi Takahashi, Kensuke Okada, Jin Nakahara, Hideyuki Okano
Summary: Significant progress has been made in drug screening for amyotrophic lateral sclerosis using patient-derived induced pluripotent stem cells, leading to the identification of candidate drugs and the advancement of clinical trials. This stem cell-based approach shows safety and positive effects, reducing costs and time compared to animal testing.
Article
Clinical Neurology
M. Khamaysa, M. Lefort, M. Pelegrini-Issac, A. Lackmy-Vallee, M. M. El Mendili, A. Preuilh, D. Devos, G. Bruneteau, F. Salachas, T. Lenglet, Md. M. Amador, N. Le Forestier, A. Hesters, J. Gonzalez, A. -S. Rolland, C. Desnuelle, M. Chupin, G. Querin, M. Georges, C. Morelot-Panzini, V. Marchand-Pauvert, P. -F. Pradat, Pulse Study Grp
Summary: This study demonstrates that brainstem volumes and spinal cord area are promising indicators for predicting respiratory intervention needs in ALS patients, with the combined model incorporating predictors from multiple models yielding the best predictive performance.
JOURNAL OF NEUROLOGY
(2023)
Article
Cell Biology
Yiyan Zheng, Chrystine M. Gallegos, Haipeng Xue, Shenglan Li, Dong H. Kim, Hongxia Zhou, Xugang Xia, Ying Liu, Qilin Cao
Summary: Recovering locomotor function after spinal cord injury (SCI) is crucial. Stem cell therapy, particularly using patient-specific induced pluripotent stem cells (iPSCs), holds promise as a reparative strategy. This study found that purified iPSC-derived neural progenitor cells (NPCs) were able to improve locomotor function in a rat model of cervical SCI.
Article
Food Science & Technology
Ivan Pavicic, Mirta Milic, Igor M. Pongrac, Lada Brkic Ahmed, Tanja Matijevic Glavan, Krunoslav Ilic, Emilija Zapletal, Marija Curlin, Dinko Mitrecic, Ivana Vinkovic Vrcek
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Medicine, General & Internal
Eitan Mijiritsky, Letizia Ferroni, Chiara Gardin, Oren Peleg, Alper Gultekin, Alper Saglanmak, Lucia Gemma Delogu, Dinko Mitrecic, Adriano Piattelli, Marco Tatullo, Barbara Zavan
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Cell Biology
Chiara Gardin, Letizia Ferroni, Christian Latremouille, Juan Carlos Chachques, Dinko Mitrecic, Barbara Zavan
Article
Biochemistry & Molecular Biology
Ivan Alic, Pollyanna A. Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Y. Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh L. O'Brien, Jurgen Groet, Xiaowei Shao, Steven Havlicek, N. Ray Dunn, Hlin Kvartsberg, Gunnar Brinkmalm, Rosalyn Hithersay, Carla Startin, Sarah Hamburg, Margaret Phillips, Konstantin Pervushin, Mark Turmaine, David Wallon, Anne Rovelet-Lecrux, Hilkka Soininen, Emanuela Volpi, Joanne E. Martin, Jia Nee Foo, David L. Becker, Agueda Rostagno, Jorge Ghiso, Zeljka Krsnik, Goran Simic, Ivica Kostovi, Dinko Mitrecic, Paul T. Francis, Kaj Blennow, Andre Strydom, John Hardy, Henrik Zetterberg, Dean Nizetic
Summary: Research has shown that individuals with Down Syndrome exhibit Alzheimer's disease-like pathological changes, which can be successfully replicated in vitro cerebral organoids models. These findings suggest that DS cerebral organoids could serve as a potential detector for pre-morbid AD-risk populations, as well as a system for hypothesis-free drug screening and identification of natural suppressor genes for neurodegenerative diseases.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Dora Polsek, Diana Cash, Mattia Veronese, Katarina Ilic, Tobias C. Wood, Milan Milosevic, Svjetlana Kalanj-Bognar, Mary J. Morrell, Steve C. R. Williams, Srecko Gajovic, Guy D. Leschziner, Dinko Mitrecic, Ivana Rosenzweig
SCIENTIFIC REPORTS
(2020)
Editorial Material
Medicine, General & Internal
Ivana Rosenzweig, Dinko Mitrecic, Zdravko Petanjek, Bobby Duffy, Allan H. Young, Alexander D. Nesbitt, Mary J. Morrell
CROATIAN MEDICAL JOURNAL
(2020)
Review
Biochemistry & Molecular Biology
Pavle Andjus, Maja Kosanovic, Katarina Milicevic, Mukesh Gautam, Seppo J. Vainio, Denis Jagecic, Elena N. Kozlova, Augustas Pivoriunas, Juan-Carlos Chachques, Mirena Sakaj, Giulia Brunello, Dinko Mitrecic, Barbara Zavan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Dinko Mitrecic, Valentina Hribljan, Denis Jagecic, Jasmina Isakovic, Federica Lamberto, Alex Horanszky, Melinda Zana, Gabor Foldes, Barbara Zavan, Augustas Pivoriunas, Salvador Martinez, Letizia Mazzini, Lidija Radenovic, Jelena Milasin, Juan Carlos Chachques, Leonora Buzanska, Min Suk Song, Andras Dinnyes
Summary: The success of in vitro cell cultivation has opened up new opportunities for medical research, particularly in the development of tissue-specific cultures and the transplantation of standardized cells for tissue regeneration. However, regenerative neurology and cardiology face different obstacles due to the unique needs of different cell types. In this review, European experts in neurology and cardiology discuss the hurdles and potential strategies for accelerating the development of these fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jasmina Isakovic, Iva Simunic, Denis Jagecic, Valentina Hribljan, Dinko Mitrecic
Summary: Neural tube defects (NTDs) are the second most common congenital malformations of humans, with genetic and environmental risk factors playing important roles. Prevention includes folic acid fortification and inositol supplementation, while treatment approaches vary depending on developmental stage and lesion location.
Article
Biotechnology & Applied Microbiology
Olesia Kalmukova, Nataliia Raksha, Tetiana Vovk, Tetiana Halenova, Mykola Dzerzhynsky, Dinko Mitrecic, Olexiy Savchuk, Ludmila Ostapchenko
Summary: This study explores the effect of low-molecular-mass collagen fragments obtained from the scales of Antarctic wild marine fish on rats' adipose tissue in a high-calorie diet-induced obesity model. The results show that the treatment with low-molecular-mass collagen fragments reduces body mass, improves morphological parameters, and decreases inflammation in obese rats.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Denis Jagecic, Drazen Juraj Petrovic, Iva Simunic, Jasmina Isakovic, Dinko Mitrecic
Summary: Perinatal brain damage, usually caused by a lack of oxygen and glucose during early development, affects cell differentiation and mitochondrial parameters. Oxygen and glucose deprivation slows down cellular differentiation, causes cell death, and decreases the overall area, length, and branching of mitochondria. Cells in all stages of differentiation exhibit increased ROS production, hyperpolarization of the mitochondrial membrane, and autophagy. Additionally, day 7 shows significant increases in mitochondrial fission and measurable instances of mitophagy. These findings have important implications for the development of therapeutic approaches targeting perinatal brain damage during specific stages of neural system development.
Article
Chemistry, Multidisciplinary
Patrick Weber, Zuzana Meszaros, Denis Jagecic, Valentina Hribljan, Dinko Mitrecic, Pavla Bojarova, Kristyna Slamova, Jiri Vrba, Natalia Kulik, Vladimir Kren, Arnold E. Stuetz
Summary: Potent and selective aminocyclopentane-derived inhibitors of human O-N-acetyl-beta-d-glucosaminidase (OGA) have been developed for the treatment of Alzheimer's disease. Compound 13, for example, showed nanomolar OGA inhibition and 92,000-fold selectivity over human HexB. It was non-toxic and increased protein O-GlcNAcylation in murine neural cell culture, providing new alternatives for tauopathies treatment.
CHEMICAL COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
J. C. Chachoues, L. Mazzini, D. Mitrecic, B. Zavan, M. Rogante, C. Latremouille, F. Rustichelli
Summary: This article reviews the clinical experience with COVID-19 patients regarding the impact on cardiovascular, hematological, and neurological systems. It emphasizes the importance of early symptoms for diagnosis and treatment. COVID-19 is highlighted as a prothrombotic disease with high global lethality.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Gerardo Tricarico, Jasmina Isakovic, Min Suk Song, Franco Rustichelli, Valter Travagli, Dinko Mitrecic
NEUROSCIENCE LETTERS
(2020)
Review
Medicine, General & Internal
Dinko Mitrecic, Drazen Juraj Petrovic, Paula Stancin, Jasmina Isakovic, Barbara Zavan, Gerardo Tricarico, Mirjana Kujundzic Tiljak, Monica Di Luca
CROATIAN MEDICAL JOURNAL
(2020)