Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models

Psychiatry in a Dish: Stem Cells and Brain Organoids Modeling Autism Spectrum Disorders

(2018) Mirolyba Ilieva et al.   BIOLOGICAL PSYCHIATRY

Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size

(2018) Matthew B. Johnson et al.   NATURE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Neanderthal brain organoids come to life

(2018) Jon Cohen   SCIENCE

Genetics and mechanisms leading to human cortical malformations

(2018) Delfina M. Romero et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mob2 Insufficiency Disrupts Neuronal Migration in the Developing Cortex

(2018) Adam C. O’Neill et al.   Frontiers in Cellular Neuroscience

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice

(2018) I-Ling Lu et al.   Nature Communications

De novo and inherited private variants in MAP1B in periventricular nodular heterotopia

(2018) Erin L. Heinzen et al.   PLoS Genetics

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

(2018) Olivia Krefft et al.   Jove-Journal of Visualized Experiments

Reconstructing the genetic history of late Neanderthals

(2018) Mateja Hajdinjak et al.   NATURE

Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development

(2018) Richard S. Smith et al.   NEURON

Exploring landscapes of brain morphogenesis with organoids

(2018) Denis Jabaudon et al.   DEVELOPMENT

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy

(2017) Sali M K Farhan et al.   HUMAN MOLECULAR GENETICS

Probing impaired neurogenesis in human brain organoids exposed to alcohol

(2017) Yujuan Zhu et al.   Integrative Biology

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

Human mutations in integrator complex subunits link transcriptome integrity to brain development

(2017) Renske Oegema et al.   PLoS Genetics

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex

(2017) Sara Bizzotto et al.   Scientific Reports

Biallelic Mutations in TMTC3, Encoding a Transmembrane and TPR-Containing Protein, Lead to Cobblestone Lissencephaly

(2016) Julie Jerber et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities

(2016) Guo-li Ming et al.   Cell Stem Cell

2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

(2016) Tomoki Otani et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Human adaptation and evolution by segmental duplication

(2016) Megan Y Dennis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Modeling psychiatric disorders with patient-derived iPSCs

(2016) Zhexing Wen et al.   CURRENT OPINION IN NEUROBIOLOGY

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

(2016) Elke Gabriel et al.   EMBO JOURNAL

Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

(2016) Zhen Liu et al.   NATURE

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Mutations in the HECT domain of NEDD4L lead to AKT–mTOR pathway deregulation and cause periventricular nodular heterotopia

(2016) Loïc Broix et al.   NATURE GENETICS

Neuronal migration disorders: Focus on the cytoskeleton and epilepsy

(2016) Melissa A. Stouffer et al.   NEUROBIOLOGY OF DISEASE

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development

(2016) Tomasz J. Nowakowski et al.   NEURON

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit

(2016) Chun-Ting Lee et al.   NEUROPSYCHOPHARMACOLOGY

Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?

(2016) A. S. Oliveira Melo et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Efficient Generation of Corticofugal Projection Neurons from Human Embryonic Stem Cells

(2016) Xiaoqing Zhu et al.   Scientific Reports

Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium

(2016) Beth A. Lindborg et al.   Stem Cells Translational Medicine

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

(2016) Xiang-Chun Ju et al.   eLife

Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

(2016) Felipe Mora-Bermúdez et al.   eLife

Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System

(2016) Alessandra Rigamonti et al.   Stem Cell Reports

Organoids and the genetically encoded self-assembly of embryonic stem cells

(2015) David A. Turner et al.   BIOESSAYS

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

(2015) Takanori Takebe et al.   Cell Stem Cell

Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells

(2015) I. K. Suzuki et al.   DEVELOPMENT

Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development

(2015) C. Badouel et al.   DEVELOPMENT

Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly

(2015) C. de Juan Romero et al.   EMBO JOURNAL

Neuronal Migration Dynamics in the Developing Ferret Cortex

(2015) C. C. Gertz et al.   JOURNAL OF NEUROSCIENCE

Rcan1 Deficiency Impairs Neuronal Migration and Causes Periventricular Heterotopia

(2015) Y. Li et al.   JOURNAL OF NEUROSCIENCE

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

(2015) J M Madison et al.   MOLECULAR PSYCHIATRY

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

The Outer Subventricular Zone and Primate-Specific Cortical Complexification

(2015) Colette Dehay et al.   NEURON

Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease

(2015) Ender Karaca et al.   NEURON

Genomic Variants and Variations in Malformations of Cortical Development

(2015) Saumya S. Jamuar et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

(2015) M. Florio et al.   SCIENCE

Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex

(2015) Elise Peyre et al.   Frontiers in Cellular Neuroscience

Morphological and functional aspects of progenitors perturbed in cortical malformations

(2015) Sara Bizzotto et al.   Frontiers in Cellular Neuroscience

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Generating Human Neurons In Vitro and Using Them to Understand Neuropsychiatric Disease

(2014) Sergiu P. Paşca et al.   Annual Review of Neuroscience

Baraitser–Winter cerebrofrontofacial syndrome: delineation of the spectrum in 42 cases

(2014) Alain Verloes et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Proliferative Defects and Formation of a Double Cortex in Mice Lacking Mltt4 and Cdh2 in the Dorsal Telencephalon

(2014) C. Gil-Sanz et al.   JOURNAL OF NEUROSCIENCE

Malformations of cortical development: clinical features and genetic causes

(2014) Renzo Guerrini et al.   LANCET NEUROLOGY

One gene, many neuropsychiatric disorders: lessons from Mendelian diseases

(2014) Xiaolin Zhu et al.   NATURE NEUROSCIENCE

Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human

(2014) Michel Kielar et al.   NATURE NEUROSCIENCE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Growth and folding of the mammalian cerebral cortex: from molecules to malformations

(2014) Tao Sun et al.   NATURE REVIEWS NEUROSCIENCE

Periventricular Nodular Heterotopia and Dystonia Due to an ARFGEF2 Mutation

(2014) Eduardo Jesús Bardón-Cancho et al.   PEDIATRIC NEUROLOGY

Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient

(2014) Amy E. Reddington et al.   Frontiers in Cellular Neuroscience

The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration

(2014) Marie-Theres Schmid et al.   Frontiers in Cellular Neuroscience

Mutations in LAMB1 Cause Cobblestone Brain Malformation without Muscular or Ocular Abnormalities

(2013) Farid Radmanesh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

New insights into genotype–phenotype correlations for the doublecortin-related lissencephaly spectrum

(2013) Nadia Bahi-Buisson et al.   BRAIN

Overlapping cortical malformations and mutations in TUBB2B and TUBA1A

(2013) Thomas D. Cushion et al.   BRAIN

Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene

(2013) Valerio Conti et al.   BRAIN

Cellular and molecular mechanisms controlling the migration of neocortical interneurons

(2013) Oscar Marín   EUROPEAN JOURNAL OF NEUROSCIENCE

LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex

(2013) Hyang Mi Moon et al.   HUMAN MOLECULAR GENETICS

Cerebellar ataxia, mental retardation and dysequilibrium syndrome 1 (CAMRQ1) caused by an unusual constellation of VLDLR mutation

(2013) Lars Schlotawa et al.   JOURNAL OF NEUROLOGY

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Using Whole-Exome Sequencing to Identify Inherited Causes of Autism

(2013) Timothy W. Yu et al.   NEURON

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate

(2013) Marion Betizeau et al.   NEURON

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic Mutation, Genomic Variation, and Neurological Disease

(2013) A. Poduri et al.   SCIENCE

Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type

(2013) Gregor-Alexander Pilz et al.   Nature Communications

A developmental and genetic classification for malformations of cortical development: update 2012

(2012) A. James Barkovich et al.   BRAIN

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Emerging roles of neural stem cells in cerebral cortex development and evolution

(2012) Víctor Borrell et al.   Developmental Neurobiology

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

A Radial Glia-Specific Role of RhoA in Double Cortex Formation

(2012) Silvia Cappello et al.   NEURON

De Novo Gene Disruptions in Children on the Autistic Spectrum

(2012) Ivan Iossifov et al.   NEURON

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo genetic manipulation of cortical progenitors in gyrencephalic carnivores using in utero electroporation

(2012) H. Kawasaki et al.   Biology Open

Human Mutations in NDE1 Cause Extreme Microcephaly with Lissencephaly

(2011) Fowzan S. Alkuraya et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evo-Devo and Brain Scaling: Candidate Developmental Mechanisms for Variation and Constancy in Vertebrate Brain Evolution

(2011) Christine J. Charvet et al.   BRAIN BEHAVIOR AND EVOLUTION

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Molecular Genetics of Neuronal Migration Disorders

(2011) Judy S. Liu   Current Neurology and Neuroscience Reports

A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A

(2011) Aurelie Carabalona et al.   HUMAN MOLECULAR GENETICS

The Outermost Region of the Developing Cortical Plate Is Crucial for Both the Switch of the Radial Migration Mode and the Dab1-Dependent "Inside-Out" Lamination in the Neocortex

(2011) K. Sekine et al.   JOURNAL OF NEUROSCIENCE

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

Intragenic rearrangements in LARGE and POMGNT1 genes in severe dystroglycanopathies

(2011) S. Vuillaumier-Barrot et al.   NEUROMUSCULAR DISORDERS

COL4A1 Mutations Cause Ocular Dysgenesis, Neuronal Localization Defects, and Myopathy in Mice and Walker-Warburg Syndrome in Humans

(2011) Cassandre Labelle-Dumais et al.   PLoS Genetics

GPR56-related bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone complex

(2010) Nadia Bahi-Buisson et al.   BRAIN

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex

(2010) Isabel Reillo et al.   CEREBRAL CORTEX

Cortical progenitor expansion, self-renewal and neurogenesis—a polarized perspective

(2010) Simone A Fietz et al.   CURRENT OPINION IN NEUROBIOLOGY

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Genetic Mosaic Dissection of Lis1 and Ndel1 in Neuronal Migration

(2010) Simon Hippenmeyer et al.   NEURON

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Generation of transgenic non-human primates with germline transmission

(2009) Erika Sasaki et al.   NATURE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Prenatal exposure to drugs: effects on brain development and implications for policy and education

(2009) Barbara L. Thompson et al.   NATURE REVIEWS NEUROSCIENCE

Evolution of the neocortex: a perspective from developmental biology

(2009) Pasko Rakic   NATURE REVIEWS NEUROSCIENCE

Neuronal migration disorders

(2009) Renzo Guerrini et al.   NEUROBIOLOGY OF DISEASE

Congenital muscular dystrophies with defective glycosylation of dystroglycan: A population study

(2009) E. Mercuri et al.   NEUROLOGY

Impaired migration signaling in the hippocampus following prenatal hypoxia

(2009) M. Hava Golan et al.   NEUROPHARMACOLOGY

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

(2008) Y. Elkabetz et al.   GENES & DEVELOPMENT

Making bigger brains-the evolution of neural-progenitor-cell division

(2008) J. L. Fish et al.   JOURNAL OF CELL SCIENCE

GPR56 Regulates Pial Basement Membrane Integrity and Cortical Lamination

(2008) S. Li et al.   JOURNAL OF NEUROSCIENCE

An intrinsic mechanism of corticogenesis from embryonic stem cells

(2008) Nicolas Gaspard et al.   NATURE

Malformations of Cortical Development

(2008) Trudy Pang et al.   NEUROLOGIST

Epilepsy in Dcx Knockout Mice Associated with Discrete Lamination Defects and Enhanced Excitability in the Hippocampus

(2008) Marika Nosten-Bertrand et al.   PLoS One