Biomarkers of β-Cell Stress and Death in Type 1 Diabetes

Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes

(2016) Emily K. Sims et al.   DIABETES CARE

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice

(2016) Jinxiu Rui et al.   DIABETOLOGIA

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

(2016) Renecia A. Watkins et al.   Translational Research

Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes

(2016) John A. Olsen et al.   PLoS One

Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas-Kidney Transplantation

(2015) R. Bijkerk et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Emerging role of long noncoding RNAs in autoimmune diseases

(2015) Guo-Cui Wu et al.   AUTOIMMUNITY REVIEWS

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

(2015) Marisa M. Fisher et al.   DIABETES

Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets

(2015) Ki Wook Kim et al.   DIABETES

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

(2015) Anna Motterle et al.   DIABETOLOGIA

β Cell death and dysfunction during type 1 diabetes development in at-risk individuals

(2015) Kevan C. Herold et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

(2015) Mathieu Latreille et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders

(2015) Alexander J. Lakhter et al.   MOLECULAR ENDOCRINOLOGY

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Evaluation of MicroRNA375 as a Novel Biomarker for Graft Damage in Clinical Islet Transplantation

(2015) Mazhar A. Kanak et al.   TRANSPLANTATION

Analysis of β-Cell Death in Type 1 Diabetes by Droplet Digital PCR

(2014) Sahar Usmani-Brown et al.   ENDOCRINOLOGY

Diabetes-Associated MicroRNAs in Pediatric Patients With Type 1 Diabetes Mellitus: A Cross-Sectional Cohort Study

(2014) Julia Osipova et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tissue-Specific Methylation of Human Insulin Gene and PCR Assay for Monitoring Beta Cell Death

(2014) Mohamed I. Husseiny et al.   PLoS One

Isolation, Characterization and Potential Role in Beta Cell-Endothelium Cross-Talk of Extracellular Vesicles Released from Human Pancreatic Islets

(2014) Federico Figliolini et al.   PLoS One

From immunobiology to β-cell biology: The changing perspective on type 1 diabetes

(2014) Aarthi Maganti et al.   Islets

Immune Therapy and  -Cell Death in Type 1 Diabetes

(2013) J. Lebastchi et al.   DIABETES

Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes

(2013) Chaoxing Yang et al.   DIABETOLOGIA

Detection of Islet β-Cell Death in Vivo by Multiplex PCR Analysis of Differentially Methylated DNA

(2013) Marisa M. Fisher et al.   ENDOCRINOLOGY

Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice

(2013) Suheda Erener et al.   ENDOCRINOLOGY

Circulating microRNAs as novel biomarkers for diabetes mellitus

(2013) Claudiane Guay et al.   Nature Reviews Endocrinology

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis

(2013) Martijn van de Bunt et al.   PLoS One

Urinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy

(2013) Federica Barutta et al.   PLoS One

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

(2012) Y. Lee et al.   HUMAN MOLECULAR GENETICS

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Development of a Quantitative Methylation-Specific Polymerase Chain Reaction Method for Monitoring Beta Cell Death in Type 1 Diabetes

(2012) Mohamed I. Husseiny et al.   PLoS One

How Does Type 1 Diabetes Develop?: The Notion of Homicide or  -Cell Suicide Revisited

(2011) M. A. Atkinson et al.   DIABETES

Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity

(2011) Guido Sebastiani et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Detection of   cell death in diabetes using differentially methylated circulating DNA

(2011) E. M. Akirav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases

(2011) Vincent Plagnol et al.   PLoS Genetics

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic  -Cells

(2010) E. Roggli et al.   DIABETES

Proinsulin/C-peptide ratio, glucagon and remission in new-onset Type 1 diabetes mellitus in young adults

(2010) A. Schölin et al.   DIABETIC MEDICINE

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

(2010) B. T. Yang et al.   DIABETOLOGIA

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insulin Gene Expression Is Regulated by DNA Methylation

(2009) Akio Kuroda et al.   PLoS One

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL