Lipids and immunoinflammatory pathways of beta cell destruction

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Expression Pattern of 12-Lipoxygenase in Human Islets With Type 1 Diabetes and Type 2 Diabetes

(2015) Wojciech J. Grzesik et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

(2015) Anne-Claire Duchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction

(2014) David A. Taylor-Fishwick et al.   DIABETOLOGIA

Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes

(2014) Matthew J. Butcher et al.   DIABETOLOGIA

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

(2014) Clara Westwell-Roper et al.   IMMUNOLOGY AND CELL BIOLOGY

Adipose Tissue 12/15 Lipoxygenase Pathway in Human Obesity and Diabetes

(2014) David C. Lieb et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets

(2014) S. A. Tersey et al.   MOLECULAR AND CELLULAR BIOLOGY

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

A Smad Signaling Network Regulates Islet Cell Proliferation

(2013) Y. El-Gohary et al.   DIABETES

Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease

(2013) Y. Imai et al.   DIABETES OBESITY & METABOLISM

Islet inflammation: a unifying target for diabetes treatment?

(2013) Yumi Imai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

(2012) Jessica R. Weaver et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid

(2011) Yande Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase

(2011) Victor Kenyon et al.   JOURNAL OF MEDICINAL CHEMISTRY

12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets

(2010) K. Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Functional and pathological roles of the 12- and 15-lipoxygenases

(2010) Anca D. Dobrian et al.   PROGRESS IN LIPID RESEARCH

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by western diet

(2008) Craig S. Nunemaker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM