Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine

Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons

(2018) Amy E. Rumora et al.   FASEB JOURNAL

Keeping the home fires burning: AMP-activated protein kinase

(2018) D. Grahame Hardie   Journal of the Royal Society Interface

Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy

(2018) Veera Ganesh Yerra et al.   NEUROPHARMACOLOGY

Cellular death, reactive oxygen species (ROS) and diabetic complications

(2018) Caroline Maria Oliveira Volpe et al.   Cell Death & Disease

MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease

(2018) Maximilian Pohland et al.   Alzheimers Research & Therapy

Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats

(2017) Mohamad-Reza Aghanoori et al.   EXPERIMENTAL NEUROLOGY

Puerarin may protect against Schwann cell damage induced by glucose fluctuation

(2017) Bing Xue et al.   Journal of Natural Medicines

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Schwann cell interactions with axons and microvessels in diabetic neuropathy

(2017) Nádia P. Gonçalves et al.   Nature Reviews Neurology

Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease

(2017) Chee-Hoe Ng et al.   NEUROBIOLOGY OF AGING

Altered expression of IRS2 and GRB2 in demyelination of peripheral neurons: Implications in diabetic neuropathy

(2017) Mallahalli S. Manu et al.   NEUROPEPTIDES

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

(2017) Sonia Sifuentes-Franco et al.   Journal of Diabetes Research

mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

(2017) Krish Chandrasekaran et al.   Annals of Clinical and Translational Neurology

Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

(2017) Liming Yu et al.   Scientific Reports

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1  pathway

(2016) Y. Yuan et al.   CLINICAL SCIENCE

Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain

(2016) Theodore J. Price et al.   CURRENT DRUG TARGETS

Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths

(2016) Johanne E. Rinholm et al.   GLIA

PGC-1α, glucose metabolism and type 2 diabetes mellitus

(2016) Haijiang Wu et al.   JOURNAL OF ENDOCRINOLOGY

Anti-Apoptotic Effect of IGF1 on Schwann Exposed to Hyperglycemia is Mediated by Neuritin, a Novel Neurotrophic Factor

(2016) Lingfei Yan et al.   MOLECULAR NEUROBIOLOGY

Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation

(2016) Veera Ganesh Yerra et al.   MOLECULAR NEUROBIOLOGY

Sugar Composition Analysis of Fuzi Polysaccharides by HPLC-MSn and Their Protective Effects on Schwann Cells Exposed to High Glucose

(2016) Bei-Bei Wang et al.   MOLECULES

A 10-yr follow-up study for the detection of peripheral neuropathy in young patients with type 1 diabetes

(2016) Gabriel Hajas et al.   PEDIATRIC DIABETES

Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function

(2016) Luis Miguel Román-Pintos et al.   Journal of Diabetes Research

Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy

(2015) Krish Chandrasekaran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Dysfunction in Diabetic Neuropathy: a Series of Unfortunate Metabolic Events

(2015) Paul Fernyhough   Current Diabetes Reports

Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin

(2015) Junxiong Ma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective Activity of Coptisine fromCoptis chinensis(Franch)

(2015) Thomas Friedemann et al.   Evidence-based Complementary and Alternative Medicine

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

mRNA Expression Levels of PGC-1α in a Transgenic and a Toxin Model of Huntington’s Disease

(2014) Rita Török et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells

(2014) Thomas Friedemann et al.   JOURNAL OF ETHNOPHARMACOLOGY

PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy

(2014) Joungil Choi et al.   NEUROBIOLOGY OF DISEASE

Fuzi Attenuates Diabetic Neuropathy in Rats and Protects Schwann Cells from Apoptosis Induced by High Glucose

(2014) Jing Han et al.   PLoS One

Therapeutic Effects of Fenofibrate on Diabetic Peripheral Neuropathy by Improving Endothelial and Neural Survival in db/db Mice

(2014) Ye Rim Cho et al.   PLoS One

Hyperglycemia- and neuropathy-induced changes in mitochondria within sensory nerves

(2014) Hussein S. Hamid et al.   Annals of Clinical and Translational Neurology

NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration

(2013) Sébastien Magnifico et al.   FASEB JOURNAL

Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy

(2013) Andreu Viader et al.   NEURON

Diabetic peripheral neuropathy: Current perspective and future directions

(2013) Randhir Singh et al.   PHARMACOLOGICAL RESEARCH

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

(2012) Subir K. Roy Chowdhury et al.   BRAIN

Dietary obesity-associated Hif1  activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

(2012) J. Krishnan et al.   GENES & DEVELOPMENT

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1α-Sirt3 Axis

(2012) Xiaoyan Yu et al.   MOLECULES

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

(2012) Subir K. Roy Chowdhury et al.   NEUROBIOLOGY OF DISEASE

Protective Effects of Salvianolic Acid B on Schwann Cells Apoptosis Induced by High Glucose

(2012) Lian-Qing Sun et al.   NEUROCHEMICAL RESEARCH

Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents

(2012) Ali Saleh et al.   NEUROPHARMACOLOGY

Terminal arbor degeneration - a novel lesion produced by the antineoplastic agent paclitaxel

(2011) Gary J. Bennett et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes

(2011) Subir K. Roy Chowdhury et al.   MITOCHONDRION

Targeting Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Preclinical Models Reveals a Potential Mechanism for the Treatment of Neuropathic Pain

(2011) Ohannes K Melemedjian et al.   Molecular Pain

GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: Implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting

(2011) Anna M.W. Taylor et al.   PAIN

Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy

(2010) Andrea M. Vincent et al.   ACTA NEUROPATHOLOGICA

Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats

(2010) E. Akude et al.   DIABETES

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Early Neural and Vascular Dysfunctions in Diabetic Rats Are Largely Sequelae of Increased Sorbitol Oxidation

(2009) Yasuo Ido et al.   ANTIOXIDANTS & REDOX SIGNALING

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

(2009) Teayoun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diabetes regulates mitochondrial biogenesis and fission in mouse neurons

(2009) J. L. Edwards et al.   DIABETOLOGIA

The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways

(2008) Jiyun Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synaptic Ultrastructural Alterations Anticipate the Development of Neuroaxonal Dystrophy in Sympathetic Ganglia of Aged and Diabetic Mice

(2008) Robert E. Schmidt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY