The role of P2Y12 receptor in ischemic stroke of atherosclerotic origin

Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice

(2018) Byambasuren Ganbaatar et al.   ATHEROSCLEROSIS

Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial

(2017) Pierre Amarenco et al.   LANCET NEUROLOGY

Effects of ticagrelor in a mouse model of ischemic stroke

(2017) Keita Yamauchi et al.   Scientific Reports

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in MiceSignificance

(2016) Yacine Boulaftali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The active metabolite of prasugrel, R-138727, improves cerebral blood flow and reduces cerebral infarction and neurologic deficits in a non-human primate model of acute ischaemic stroke

(2016) Atsuhiro Sugidachi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Association BetweenCYP2C19Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic Attack

(2016) Yilong Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack

(2016) S. Claiborne Johnston et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke

(2016) Keun-Sik Hong et al.   STROKE

Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis

(2016) Michael R. Preusch et al.   Drug Design Development and Therapy

Prasugrel inhibits platelet-enhanced pro-inflammatory CD4+ T cell responses in humans

(2015) L.R. Johnston et al.   ATHEROSCLEROSIS

Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo

(2015) Christian Heim et al.   HEART AND VESSELS

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

CYP2C19 polymorphism and clinical outcomes among patients of different races treated with clopidogrel: A systematic review and meta-analysis

(2015) Xuan Niu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

RAP1-GTPase signaling and platelet function

(2015) Lucia Stefanini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Dual antiplatelet therapy in stroke and ICAS

(2015) Liping Liu et al.   NEUROLOGY

Prasugrel reduces ischaemic infarct volume and ameliorates neurological deficits in a non-human primate model of middle cerebral artery thrombosis

(2015) Atsuyuki Tomizawa et al.   THROMBOSIS RESEARCH

Vessel wall, not platelet, P2Y12 potentiates early atherogenesis

(2014) L. E. West et al.   CARDIOVASCULAR RESEARCH

Microglia is a Key Player in the Reduction of Stroke Damage Promoted by the New Antithrombotic Agent Ticagrelor

(2014) Paolo Gelosa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Agonist-bound structure of the human P2Y12 receptor

(2014) Jin Zhang et al.   NATURE

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

(2014) Kaihua Zhang et al.   NATURE

Overview of pleiotropic effects of platelet P2Y12 receptor inhibitors

(2014) Marek Koziński et al.   THROMBOSIS AND HAEMOSTASIS

Roles of Purinergic Receptor P2Y, G Protein–Coupled 12 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

(2012) Ding Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling

(2012) Xinming Su et al.   JOURNAL OF CLINICAL INVESTIGATION

The platelet P2Y12receptor contributes to granule secretion through Ephrin A4 receptor

(2012) Erik Tournoij et al.   PLATELETS

P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells

(2012) Christian Gachet   Purinergic Signalling

Comparison of Differential Expression of P2Y12 Receptor in Culprit Coronary Plaques in Patients With Acute Myocardial Infarction Versus Stable Angina Pectoris

(2011) Cheol Whan Lee et al.   AMERICAN JOURNAL OF CARDIOLOGY

The β-Chain of Cell Surface F 0 F 1 ATPase Modulates ApoA-I and HDL Transcytosis Through Aortic Endothelial Cells

(2011) Clara Cavelier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Beneficial effect of anti-platelet therapies on atherosclerotic lesion formation assessed by phase-contrast X-ray CT imaging

(2011) Masafumi Takeda et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Real-time Imaging Reveals That P2Y2and P2Y12Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3-Kinase (PI3K)- and p38 Mitogen-activated Protein Kinase (MAPK)-independent

(2011) Katrin Isfort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clopidogrel, a P2Y12 Receptor Antagonist, Potentiates the Inflammatory Response in a Rat Model of Peptidoglycan Polysaccharide-Induced Arthritis

(2011) Analia E. Garcia et al.   PLoS One

Adenosine Diphosphate Receptor P2Y12-Mediated Migration of Host Smooth Muscle-Like Cells and Leukocytes in the Development of Transplant Arteriosclerosis

(2011) Kosuke Harada et al.   TRANSPLANTATION

Regulation of Functionally Active P2Y12 ADP Receptors by Thrombin in Human Smooth Muscle Cells and the Presence of P2Y12 in Carotid Artery Lesions

(2010) Bernhard H. Rauch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2generation mediated by Gisignalling pathways

(2010) Analia Garcia et al.   BIOCHEMICAL JOURNAL

The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects

(2010) M. Cattaneo   BLOOD

Genetic Variation in Metabolizing Enzyme and Transporter Genes: Comprehensive Assessment in 3 Major East Asian Subpopulations With Comparison to Caucasians and Africans

(2010) Michael Man et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP

(2010) A. Ben Addi et al.   JOURNAL OF IMMUNOLOGY

CalDAG-GEFI and platelet activation

(2010) Lucia Stefanini et al.   PLATELETS

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes

(2009) Philipp Diehl et al.   BASIC RESEARCH IN CARDIOLOGY

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis

(2009) S. Amadio et al.   CEREBRAL CORTEX

The reversible oral P2Y12 antagonist AZD6140 inhibits ADP-induced contractions in murine and human vasculature

(2009) Carl Högberg et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice

(2009) Arnon Afek et al.   MICROVASCULAR RESEARCH

Involvement of Platelet Activation by P2Y12 Receptor in the Development of Transplant Arteriosclerosis in Mice

(2009) Kenichi Yashiro et al.   TRANSPLANTATION

Inflammatory and non-invasive vascular markers: The multimarker approach for risk stratification in coronary artery disease

(2008) Ignatios Ikonomidis et al.   ATHEROSCLEROSIS

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin  IIb 3 in platelets

(2008) S. M. Cifuni et al.   BLOOD

Multiple ways to switch platelet integrins on and off

(2008) J. M. E. M. COSEMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Studies on the role of the extracellular cysteines and oligomeric structures of the P2Y12receptor when interacting with antagonists

(2008) ZHONGREN DING et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS