Review
Cell Biology
Ricardo Huilcaman, Whitney Venturini, Lucia Fuenzalida, Angel Cayo, Raul Segovia, Claudio Valenzuela, Nelson Brown, Rodrigo Moore-Carrasco
Summary: Platelets play important roles in thrombosis-dependent obstructive cardiovascular diseases and also participate in the earliest stages of atherosclerosis, while serving as modulators of inflammation.
Article
Cardiac & Cardiovascular Systems
Emanuela Marcantoni, Michael S. Garshick, Tamar Schwartz, Nicole Ratnapala, Matthew Cambria, Rebecca Dann, Meagan O'Brien, Adriana Heguy, Jeffrey S. Berger
Summary: Clopidogrel, compared with aspirin and no-treatment, reduces platelet activation and the risk of cardiovascular disease in HIV-positive patients.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Cell Biology
Xiaowei Liu, Yizhong Bao, Zhang Lin, Lijiang Tang, Ping Mao
Summary: Platelet transfusion can effectively inhibit the development of atherosclerosis in mice by improving lipid metabolism and suppressing inflammatory responses in the vascular wall.
Article
Clinical Neurology
Victor J. Del Brutto, Ruijie Yin, Hannah Gardener, Hao Ying, Carolina M. Gutierrez, Angus M. Jameson, David Z. Rose, Ayham Alkhachroum, Dianne Foster, Chuanhui Dong, Selina Ancheta, Nicole B. Sur, Gillian Gordon Perue, Tatjana Rundek, Negar Asdaghi, Ralph L. Sacco, Jose G. Romano
Summary: The study found an increasing trend in short-term dual antiplatelet therapy (DAPT) prescription after mild noncardioembolic ischemic stroke (NCIS) in the Florida Stroke Registry, but also identified substantial underutilization of evidence-based DAPT and significant disparities in stroke care.
Article
Hematology
Peng-Xin Ge, Ting Tai, Li -Ping Jiang, Jin-Zi Ji, Qiong-Yu Mi, Ting Zhu, Yi-Fei Li, Hong-Guang Xie
Summary: Choline and TMAO impair the metabolic activation of and platelet response to clopidogrel through the activation of the NOX-dependent ROS/Nrf2/CES1 pathway, suggesting novel strategies for overcoming clopidogrel resistance from bench to bedside.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, Research & Experimental
Chaojun Tang, Lei Wang, Yulan Sheng, Zhong Zheng, Zhanli Xie, Fan Wu, Tao You, Lijie Ren, Lijun Xia, Changgeng Ruan, Li Zhu
Summary: This study demonstrated that disturbed blood flow can induce platelet accumulation in atherosclerosis, with CLEC-2 gene knockout potentially reducing subendothelial accumulation of platelets and monocytes/macrophages, thereby ameliorating plaque formation.
Article
Microbiology
Aisling R. Caffrey, Haley J. Appaneal, Kerry L. LaPlante, Vrishali V. Lopes, Erlinda R. Ulloa, Victor Nizet, George Sakoulas
Summary: This study demonstrates that the use of P2Y12 inhibitor clopidogrel can reduce in-hospital mortality in patients with Staphylococcus aureus bacteremia.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Dawn S. Kuszynski, Barbara D. Christian, Anne M. Dorrance, D. Adam Lauver
Summary: Clopidogrel is an effective antagonist of the purinergic 2Y(12) receptor used to prevent arterial thrombosis, but its use is associated with adverse bleeding. Studies suggest that clopidogrel may cause adverse cerebral bleeding by inhibiting the endothelial P2Y(2) receptor in the middle cerebral artery.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kerstin Jurk, Korbinian F. Rothenaicher, Kathrin Gross, Heidi Rossmann, Gerhard Weisser, Irene Schmidtmann, Thomas Muenzel, Christine Espinola-Klein
Summary: Combination therapy with ASA and low-dose rivaroxaban has inhibitory effect on CD36-sensitive platelet thrombin formation, reducing major adverse cardiac and limb events in PAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Bernadeta Chyrchel, Olga Kruszelnicka, Andrzej Surdacki
Summary: This study compared the effects of ticagrelor and clopidogrel on endothelial biomarkers and platelet reactivity in patients with acute coronary syndrome (ACS). The results showed that ticagrelor users had decreased platelet aggregation and soluble P-selectin levels compared to clopidogrel users. In addition, T2DM patients on ticagrelor had lower levels of soluble vascular cell adhesion molecule-1 compared to those on clopidogrel.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rosa Suades, Teresa Padro, Gemma Vilahur, Lina Badimon
Summary: Platelets play essential roles in thrombosis, inflammation, and angiogenesis. Stimulation by thrombin triggers the release of pEVs from platelets, which are rich in procoagulant and proadhesive proteins. Differential proteomic analysis revealed significant changes in protein composition between pEVs from activated platelets and non-activated platelets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Hematology
Sean P. Heffron, Ada Weinstock, Bianca Scolaro, Shiyu Chen, Brian E. Sansbury, Greg Marecki, Christina C. Rolling, Hanane El Bannoudi, Tessa Barrett, James W. Canary, Matthew Spite, Jeffrey S. Berger, Edward A. Fisher
Summary: Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. This effect is partially mediated by prostaglandin E2 stimulating the EP4 receptor on macrophages, leading to altered gene expression and function.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Marivee Borges-Rodriguez, Corbin A. Shields, Olivia K. Travis, Robert W. Tramel, Cedar H. Baik, Chelsea A. Giachelli, Jan MichaelWilliams, Geilda A. Tardo, Jan Michael Williams, Denise C. Cornelius
Summary: The study suggests that activated platelets may contribute to sepsis-induced renal injury through NLRP3 activation in platelets, indicating platelets could be a therapeutic target for reducing renal injury in septic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nishank Jain, Adam Corken, John M. Arthur, Jerry Ware, Narenraj Arulprakash, Junqiang Dai, Milind A. Phadnis, Otis Davis, Yasir Rahmatallah, J. L. Mehta, S. Susan Hedayati, Susan Smyth
Summary: This study compared the pharmacologic properties of ticagrelor and clopidogrel in non-dialysis patients with stage 4-5 CKD, and found that ticagrelor had better platelet aggregation inhibition and anti-inflammatory effects.
VASCULAR PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matheus Henrique Jantsch, Pedro Henrique Doleski, Altevir Rossato Viana, Jean Lucas Gutknecht da Silva, Daniela Ferreira Passos, Fernanda Licker Cabral, Alessandra Guedes Manzoni, Renan da Silva Ebone, Ana Barbara Uchoa Soares, Cinthia Melazzo de Andrade, Maria Rosa Chitolina Schetinger, Daniela Bitencourt Rosa Leal
Summary: Metastatic melanoma, an aggressive skin cancer, can be influenced by platelet activation, which is controlled by P2Y12 receptor and purinergic enzymes. Inhibition of P2Y12 with clopidogrel bisulfate (CB) has shown significant effects in reducing cell viability and proliferation in B16-F10 culture, as well as decreasing tumor nodule counts and lactate dehydrogenase levels, and increasing platelet purine metabolism in a melanoma mouse model. These findings indicate the potential of CB in modulating melanoma progression.
BIOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gloria Faerber, Sabine Bleiziffer, Torsten Doenst, Dimitra Bon, Andreas Boening, Helge Weiler, Eva Herrmann, Christian Frerker, Andreas Beckmann, Helge Moellmann, Stephan Ensminger, Raffi Bekeredjian, Thomas Walther, Wolfgang Harringer, Hugo A. Katus, Christian W. Hamm, Friedhelm Beyersdorf, Timm Bauer, Stephan Fichtlscherer
Summary: Chronic dialysis patients with AS undergoing TAVI or SAVR had similar 1-year mortality rates, with better survival at 30 days for TAVI patients. TAVI may improve peri-procedural outcomes, although TAVI patients required more pacemaker implantation and showed more aortic regurgitation, while SAVR patients required more blood transfusions and had longer hospital stays.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Immunology
Susann Goerner, Christian Heim, Benno Weigmann, Benjamin Von Silva-Tarouca, Annika Kuckhahn, Martina Ramsperger-Gleixner, Robert Zimmermann, Michael Weyand, Stephan M. Ensminger
Summary: This study found that human platelets play an important role in the development of transplant arteriosclerosis. Activated human platelets can promote platelet adhesion to vascular endothelium and induce intimal proliferation. These findings are of great significance for understanding the pathogenesis of transplant arteriosclerosis.
Article
Surgery
Christian Heim, Philipp P. Mueller, Parwis Massoudy, Frank Harig, Ehab Nooh, Michael Weyand, Markus Czesla
Summary: Careful planning, strict mentor-mentee concept, and comprehensive training led to the successful initiation of the MICS-MVR program with excellent surgical outcomes. The majority of patients underwent minimally invasive surgery with high mitral valve repair rates.
EUROPEAN SURGICAL RESEARCH
(2022)
Article
Immunology
Christian Heim, Philipp P. Mueller, Rene Tandler, Wida S. Cherikh, Alice E. Toll, Josef Stehlik, Michael Weyand, Kiran K. Khush, Stephan M. Ensminger
Summary: This study aimed to compare posttransplant survival in different CMV donor:recipient serologic combinations. The results showed that CMV infection was associated with reduced short- and long-term survival after heart transplantation, but did not increase the risk of cardiac allograft vasculopathy.
Article
Cardiac & Cardiovascular Systems
Hiroyuki Saisho, Carina Kuhlmann, Michael Scharfschwerdt, Reuben Jeganathan, Najla Sadat, Tim Schaller, Anas Aboud, Stephan Ensminger, Buntaro Fujita
Summary: The F8 technique with the PME21 achieved a similar EOA as the 1 size larger PME23 using NE after AE. SI and CS did not result in a larger EOA compared with the NE technique. PME21 using SI had a significantly larger leakage volume than using NE and there was no significant difference between other techniques.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Physiology
Maximilian J. Klumm, Christian Heim, Dominik J. Fiegle, Michael Weyand, Tilmann Volk, Thomas Seidel
Summary: This study presents a method for long-term cultivation of beating human atrial myocardium. The authors obtained tissues from the right-atrial appendage of patients with sinus rhythm and cultivated trabeculae for up to 3 weeks. They analyzed the functional parameters, gene expression, and tissue microstructure, and confirmed the viability and electromechanical function of the cultivated myocardium. This method allows for studying the physiology and pathophysiology of human atrial myocardium.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Evaldas Girdauskas, Johannes Petersen, Uemniye Balaban, Eva Herrmann, Timm Bauer, Andreas Beckmann, Raffi Bekeredjian, Stephan Ensminger, Christian Frerker, Helge Moellmann, Thomas Walther, Sabine Bleiziffer
Summary: AV repair/AV-sparing root surgery is an effective strategy for treating young patients with aortic regurgitation and/or aortic root aneurysm. This study analyzed real-world data from the German Aortic Valve Registry and found that the surgical procedure resulted in satisfactory clinical outcomes, including high survival rates and freedom from cardiac adverse events at one year. Additionally, the specific surgical technique used did not significantly impact the outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Mohamed Elbayomi, Michael Weyand, Christian Heim, Katrin Steger, Rene Tandler
Summary: The success of LVAD as a treatment for terminal left-side heart failure is limited by complications such as pump thrombus. Treatment options include medication augmentation, thrombolysis, and pump exchange. Heart transplantation is not a practical option due to a scarcity of organ donors. Retrograde washout may be a treatment option.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Hiroyuki Saisho, Michael Scharfschwerdt, Tim Schaller, Najla Sadat, Anas Aboud, Stephan Ensminger, Buntaro Fujita
Summary: In this ex vivo study, the hydrodynamic performance and cusp kinematics of the Ozaki neocuspidized aortic valve were compared with native aortic and prosthetic valves. The results showed that the Ozaki valve had excellent hydrodynamic performance and similar cusp motion characteristics to the native aortic valve, suggesting potential beneficial clinical outcomes.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Presheet Pathare, Michael Weyand, Christian Heim
Summary: Hedinger Syndrome, also known as carcinoid heart disease, is a rare cardiac complication of neuroendocrine tumors that affects the tricuspid and pulmonary valves. This case study describes a patient with a neuroendocrine tumor with liver metastasis who underwent surgical valve replacement for symptomatic tricuspid valve regurgitation and pulmonary valve stenosis. The surgery was successfully performed before the development of severe right ventricular failure or pulmonary hypertension in this case of carcinoid heart disease. An interdisciplinary approach and regular follow-up are recommended for such cases.
CLINICAL CASE REPORTS
(2023)
Article
Microbiology
Ann-Sophie Kaemmerer, Francesco Ciotola, Walter Geissdoerfer, Frank Harig, Jochen Mattner, Timo Seitz, Mathieu N. Suleiman, Michael Weyand, Christian Heim
Summary: This article reports a blood-culture-negative dual pathogen infective endocarditis caused by Coxiella burnetii and Streptococcus gordonii. With detailed diagnosis and appropriate antibiotic therapy, the patient successfully underwent minimal-invasive mitral valve replacement without complications.
Article
Cardiac & Cardiovascular Systems
Najla Sadat, John Habakuk Lojenburg, Michael Scharfschwerdt, Buntaro Fujta, Stephan Ensminger
Summary: This in vitro study compares different in vitro models for functional testing of transcatheter heart valves (THVs). The results show that the full expansion and functional performance of THVs depend on the configuration of the testing compartment in an in vitro setting.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Najla Sadat, Michael Scharfschwerdt, Tim Schaller, Anas Aboud, Hiroyuki Saisho, Stephan Ensminger, Buntaro Fujita
Summary: The study aims to characterize the functional performance of 8 surgical aortic valve models in vitro and found significant differences in their hydrodynamic performance despite the same label size.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Presheet Pathare, Michael Weyand, Christian Heim
Summary: Cardiac myxomas, commonly found in the left atrium, are a frequent type of heart tumor. They can be asymptomatic or gradually lead to symptoms of heart failure. This case report describes a syncope caused by a large left atrial myxoma.
THORACIC AND CARDIOVASCULAR SURGEON REPORTS
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
F. Theil, A. Kuckhahn, A. Horning, M. Ramsperger-Gleixner, M. Weyand, C. Heim
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)