Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor

(2013) Peter Bach et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Lead Optimization of Ethyl 6-Aminonicotinate Acyl Sulfonamides as Antagonists of the P2Y12 Receptor. Separation of the Antithrombotic Effect and Bleeding for Candidate Drug AZD1283

(2013) Peter Bach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Restructuring G-Protein- Coupled Receptor Activation

(2012) Martin Audet et al.   CELL

High-resolution crystal structure of human protease-activated receptor 1

(2012) Cheng Zhang et al.   NATURE

The platelet P2Y12 receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [3H]PSB-0413

(2012) Philippe Ohlmann et al.   Purinergic Signalling

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

(2012) Eugene Chun et al.   STRUCTURE

Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

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Features and development ofCoot

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The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects

(2010) M. Cattaneo   BLOOD

P2Y nucleotide receptors: promise of therapeutic applications

(2010) Kenneth A. Jacobson et al.   DRUG DISCOVERY TODAY

Mutational analysis of residues important for ligand interaction with the human P2Y12 receptor

(2010) Yingying Mao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ticagrelor: The First Reversibly Binding Oral P2Y12Receptor Antagonist

(2009) Steen Husted et al.   Cardiovascular Therapeutics

Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Third Intracellular Loop Stabilizes the Inactive State of the Neuropeptide Y1 Receptor

(2008) Melissa J. S. Chee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12receptor

(2008) I. ALGAIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Studies on the role of the extracellular cysteines and oligomeric structures of the P2Y12receptor when interacting with antagonists

(2008) ZHONGREN DING et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS