RAP1-GTPase signaling and platelet function

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

P2Y12receptors: structure and function

(2015) M. Cattaneo   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics

(2014) L. M. Simon et al.   BLOOD

Platelet Immunoreceptor Tyrosine-Based Activation Motif (ITAM) Signaling and Vascular Integrity

(2014) Yacine Boulaftali et al.   CIRCULATION RESEARCH

What Can Proteomics Tell Us About Platelets?

(2014) Julia M. Burkhart et al.   CIRCULATION RESEARCH

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes

(2014) A. Amirkhosravi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Copy Number Analysis of the Murine Platelet Proteome Spanning the Complete Abundance Range

(2014) Marlis Zeiler et al.   MOLECULAR & CELLULAR PROTEOMICS

Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet

(2014) Patricia Molina-Ortiz et al.   PLoS Genetics

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane

(2012) J. Wang et al.   Biology Open

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3Outside-in Signaling

(2011) Guoying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

The kinetics of  IIb 3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

(2010) M. Stolla et al.   BLOOD

Unravelling the mechanism of dual-specificity GAPs

(2010) Begoña Sot et al.   EMBO JOURNAL

Platelet receptor signaling in thrombus formation

(2010) David Stegner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

New insights into the haemostatic function of platelets

(2009) Andrew H. Wei et al.   BRITISH JOURNAL OF HAEMATOLOGY

Platelet Adhesion under Flow

(2009) Zaverio M. Ruggeri   MICROCIRCULATION

The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb

(2009) S. Kupzig et al.   MOLECULAR AND CELLULAR BIOLOGY

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin  IIb 3 in platelets

(2008) S. M. Cifuni et al.   BLOOD