Prostaglandin-cytokine crosstalk in chronic inflammation

T cell–intrinsic prostaglandin E 2 -EP2/EP4 signaling is critical in pathogenic T H 17 cell–driven inflammation

(2018) Jinju Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E 2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis

(2018) Calum T. Robb et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E 2 suppresses human group 2 innate lymphoid cell function

(2018) Jovana Maric et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of prostanoids in gastrointestinal cancer

(2018) Dingzhi Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease

(2017) Jacqueline J. Eastman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

(2017) Tomohiro Aoki et al.   Science Signaling

Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

(2017) Tomohiro Aoki et al.   Science Signaling

Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation

(2017) Xiaohu Wang et al.   EBioMedicine

Prostaglandin I2Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses

(2016) Weisong Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2

(2016) Racquel Domingo-Gonzalez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma

(2016) Veit J. Erpenbeck et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis

(2016) R. Duffin et al.   SCIENCE

Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

(2016) Piotr Kuna et al.   Drug Design Development and Therapy

Prostaglandins E2 signal mediated by receptor subtype EP2 promotes IgE production in vivo and contributes to asthma development

(2016) Yuhan Gao et al.   Scientific Reports

Prostaglandin E2inhibits neutrophil extracellular trap formation through production of cyclic AMP

(2015) Kyosuke Shishikura et al.   BRITISH JOURNAL OF PHARMACOLOGY

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth

(2015) X. Ma et al.   CANCER RESEARCH

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways

(2015) Xiaojun Ma et al.   Cellular & Molecular Immunology

The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

(2015) E D Tait Wojno et al.   Mucosal Immunology

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

(2015) Ariane Hammitzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effects of PGE2in the lung: role of the EP4receptor subtype

(2015) Mark A Birrell et al.   THORAX

PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

(2015) Luis Rodriguez-Rodriguez et al.   ARTHRITIS RESEARCH & THERAPY

The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation

(2015) Jeniffer B. Hernandez et al.   Nature Communications

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

(2015) Lam C. Tsoi et al.   Nature Communications

Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis

(2015) Emily Hams et al.   Frontiers in Immunology

COX-1-derived thromboxane A2 plays an essential role in early B-cell development via regulation of JAK/STAT5 signaling in mouse

(2014) Q. Yang et al.   BLOOD

Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages

(2014) François Coulombe et al.   IMMUNITY

PTGER4 modulating variants in Crohn’s disease

(2014) Matthias Prager et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

(2014) David M. Kofler et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines

(2014) Rei Mizuno et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+T cell–dendritic cell interactions

(2014) Federica Moalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

(2014) Jennifer M. Monk et al.   MEDIATORS OF INFLAMMATION

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Cyclooxygenase-2 Inhibits T Helper Cell Type 9 Differentiation during Allergic Lung Inflammation via Down-regulation of IL-17RB

(2013) Hong Li et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

The Role of Polymorphonuclear Leukocyte Trafficking in the Perpetuation of Inflammation During Inflammatory Bowel Disease

(2013) Jennifer C. Brazil et al.   INFLAMMATORY BOWEL DISEASES

Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis

(2013) Jinny E. Chang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells

(2013) Zbigniew Zasłona et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process

(2013) Chiao-Wen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Th17 Cells in the Tumor Microenvironment Is Mediated by IL-23 via Tumor-Secreted Prostaglandin E2

(2013) X. Qian et al.   JOURNAL OF IMMUNOLOGY

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

(2013) David A Hinds et al.   NATURE GENETICS

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

Therapeutic opportunities of the IL-22–IL-22R1 system

(2013) Robert Sabat et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Proresolution Lipid Mediators in Multiple Sclerosis — Differential, Disease Severity-Dependent Synthesis — A Clinical Pilot Trial

(2013) Harald Prüss et al.   PLoS One

JARID1A, JMY, and PTGER4 Polymorphisms Are Related to Ankylosing Spondylitis in Chinese Han Patients: A Case-Control Study

(2013) Wei Chai et al.   PLoS One

The Transcription Factor CREB Enhances Interleukin-17A Production and Inflammation in a Mouse Model of Atherosclerosis

(2013) S. Kotla et al.   Science Signaling

Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

(2013) Chengcan Yao et al.   Nature Communications

Prostaglandin I2analogues enhance already exuberant Th17 cell responses in systemic sclerosis

(2012) Marie-Elise Truchetet et al.   ANNALS OF THE RHEUMATIC DISEASES

Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling

(2012) Z. Zaslona et al.   BLOOD

Prostaglandin E2-induced IL-23p19 Subunit Is Regulated by cAMP-responsive Element-binding Protein and C/AATT Enhancer-binding Protein β in Bone Marrow-derived Dendritic Cells

(2012) Virginia P. Kocieda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets

(2012) Xiangli Li et al.   JOURNAL OF CLINICAL INVESTIGATION

EP4 receptor signalling in immature B cells involves cAMP and NF-κB dependent pathways

(2012) Matevz Prijatelj et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The intrinsic prostaglandin E2–EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

(2012) Naoki Nakagawa et al.   KIDNEY INTERNATIONAL

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Prostaglandin I2 Signaling Drives Th17 Differentiation and Exacerbates Experimental Autoimmune Encephalomyelitis

(2012) Weisong Zhou et al.   PLoS One

Genome-Wide Association Study of Multiple Sclerosis Confirms a Novel Locus at 5p13.1

(2012) Fuencisla Matesanz et al.   PLoS One

PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites

(2012) Jürgen Glas et al.   PLoS One

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

(2012) Eimear E. Kenny et al.   PLoS Genetics

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

(2011) Luke Barron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cyclooxygenase-2 Regulates Th17 Cell Differentiation during Allergic Lung Inflammation

(2011) Hong Li et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PGE2-EP2signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB

(2011) T. Aoki et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Thromboxane A2 receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment

(2011) Tsutomu Minamino et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models

(2010) Q Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages

(2010) Manuel D. Díaz-Muñoz et al.   CELLULAR SIGNALLING

Prostaglandin E2 Signaling and Bacterial Infection Recruit Tumor-Promoting Macrophages to Mouse Gastric Tumors

(2010) Hiroko Oshima et al.   GASTROENTEROLOGY

The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge

(2010) Rui He et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

(2010) Peter M Rothwell et al.   LANCET

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth

(2009) Yasuhumi Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prostaglandin F2 -F-Prostanoid Receptor Signaling Promotes Neutrophil Chemotaxis via Chemokine (C-X-C Motif) Ligand 1 in Endometrial Adenocarcinoma

(2009) A. E. Wallace et al.   CANCER RESEARCH

Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-γ production by memory CD4+ T cells

(2009) Giorgio Napolitani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Elevated cerebrospinal fluid levels of prostaglandin E2 and 15-(S)-hydroxyeicosatetraenoic acid in multiple sclerosis

(2009) N. Mattsson et al.   JOURNAL OF INTERNAL MEDICINE

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

(2009) Toru Oga et al.   NATURE MEDICINE

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

(2009) Y. Kihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of LPS-Induced TNF-  Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105

(2009) E. A. Wall et al.   Science Signaling

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

(2008) P. Krause et al.   BLOOD

Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis

(2008) M. Nakanishi et al.   CANCER RESEARCH

Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor,Ptger4

(2008) Jernej Murn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS