Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

Proresolution Lipid Mediators in Multiple Sclerosis — Differential, Disease Severity-Dependent Synthesis — A Clinical Pilot Trial

(2013) Harald Prüss et al.   PLoS One

Prostaglandin E2 Suppresses Antifungal Immunity by Inhibiting Interferon Regulatory Factor 4 Function and Interleukin-17 Expression in T Cells

(2012) Patricia A. Valdez et al.   IMMUNITY

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

(2012) Magdalena Huber et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostaglandin E2 Affects T Cell Responses through Modulation of CD46 Expression

(2012) K. Kickler et al.   JOURNAL OF IMMUNOLOGY

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

At last, a truly selective EP2 receptor antagonist

(2011) Mark A Birrell et al.   BRITISH JOURNAL OF PHARMACOLOGY

The many faces of Th17 cells

(2011) Anneli Peters et al.   CURRENT OPINION IN IMMUNOLOGY

Prostaglandin E2 and T cells: friends or foes?

(2011) Vinatha Sreeramkumar et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Prostaglandin E2, an Immunoactivator

(2010) Daiji Sakata et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-γ production by memory CD4+ T cells

(2009) Giorgio Napolitani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNA Interference Screen in Primary Human T Cells Reveals FLT3 as a Modulator of IL-10 Levels

(2009) A. L. Astier et al.   JOURNAL OF IMMUNOLOGY

The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3

(2009) K. Kohu et al.   JOURNAL OF IMMUNOLOGY

Phenotypical Characterization of Human Th17 Cells Unambiguously Identified by Surface IL-17A Expression

(2009) V. Brucklacher-Waldert et al.   JOURNAL OF IMMUNOLOGY

Elevated cerebrospinal fluid levels of prostaglandin E2 and 15-(S)-hydroxyeicosatetraenoic acid in multiple sclerosis

(2009) N. Mattsson et al.   JOURNAL OF INTERNAL MEDICINE

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

A rush to judgment on Th17: Figure 1.

(2008) Lawrence Steinman   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY