Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia

Hepcidin agonists as therapeutic tools

(2018) Carla Casu et al.   BLOOD

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

(2017) Carla Casu et al.   HAEMATOLOGICA

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor

(2017) Shadi Khalil et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

(2017) Carla Casu et al.   HAEMATOLOGICA

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Regulation of Hepcidin by Erythropoiesis: The Story So Far

(2016) Sant-Rayn Pasricha et al.   Annual Review of Nutrition

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

(2016) Susanna Canali et al.   BLOOD

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

(2016) Philipp-Sebastian Koch et al.   BLOOD

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening

(2016) Baobing Zhao et al.   DEVELOPMENTAL CELL

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver

(2016) Ningning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis

(2016) Skye C McIver et al.   eLife

The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis

(2015) Alessandro Matte et al.   ANTIOXIDANTS & REDOX SIGNALING

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation

(2015) Nobuyuki Tanimura et al.   EMBO REPORTS

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts

(2015) Kristoff A. Olson et al.   EUROPEAN HEART JOURNAL

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

(2015) H. Chen et al.   HAEMATOLOGICA

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

(2015) C. Casu et al.   HAEMATOLOGICA

 -thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

(2015) S. Rivella   HAEMATOLOGICA

PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

(2015) Hsiang-Ying Lee et al.   NATURE

'Rejuvenating' protein doubted

(2015) J. Kaiser   SCIENCE

A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis

(2015) Raymond Liang et al.   PLoS Genetics

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

(2015) H. Chen et al.   HAEMATOLOGICA

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

(2015) C. Casu et al.   HAEMATOLOGICA

 -thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

(2015) S. Rivella   HAEMATOLOGICA

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine  -thalassemia

(2014) R. N. V. S. Suragani et al.   BLOOD

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

(2014) C. Mayeur et al.   BLOOD

The second transferrin receptor regulates red blood cell production in mice

(2014) A. Nai et al.   BLOOD

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

(2014) Thomas Sonnweber et al.   GUT

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

(2014) Michael Dussiot et al.   NATURE MEDICINE

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

(2014) Rajasekhar N V S Suragani et al.   NATURE MEDICINE

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

(2013) Pedro Ramos et al.   NATURE MEDICINE

Intestinal HIF2  promotes tissue-iron accumulation in disorders of iron overload with anemia

(2013) E. R. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased hepcidin expression in murine  -thalassemia is associated with suppression of Bmp/Smad signaling

(2012) N. L. Parrow et al.   BLOOD

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

The role of ineffective erythropoiesis in non-transfusion-dependent thalassemia

(2012) Stefano Rivella   BLOOD REVIEWS

The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice

(2012) G. Casanovas et al.   HAEMATOLOGICA

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis

(2011) Erik R. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

(2011) Séverine Coulon et al.   NATURE MEDICINE

Negative Autoregulation by Fas Stabilizes Adult Erythropoiesis and Accelerates Its Stress Response

(2011) Miroslav Koulnis et al.   PLoS One

Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis

(2011) Nermi L Parrow et al.   Expert Review of Hematology

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation

(2010) S. Millot et al.   BLOOD

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

(2010) Sutada Lotinun et al.   BONE

Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling

(2010) A-S Gabet et al.   CELL DEATH AND DIFFERENTIATION

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

(2010) Omid F. Harandi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Redundancy of myostatin and growth/differentiation factor 11 function

(2009) Alexandra C McPherron et al.   BMC DEVELOPMENTAL BIOLOGY

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

(2008) B.-M. Zhu et al.   BLOOD

Erythroblastic islands: niches for erythropoiesis

(2008) J. A. Chasis et al.   BLOOD

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in  -thalassemia

(2008) I. V. Libani et al.   BLOOD

Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study of ACE-011 (ActRIIA-IgG1) in Postmenopausal Women*

(2008) Jon Ruckle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

(2008) R. S. Pearsall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA