Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids

The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol

(2018) Bruno Antonny et al.   Annual Review of Biochemistry

How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties

(2018) Asghar M. Razavi et al.   BMC BIOLOGY

PI(4,5)P2controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites

(2018) Mira Sohn et al.   JOURNAL OF CELL BIOLOGY

Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial

(2018) Angelo Di Leo et al.   LANCET ONCOLOGY

Genetically encoded lipid biosensors

(2018) Rachel C. Wills et al.   MOLECULAR BIOLOGY OF THE CELL

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

(2018) Ji She et al.   NATURE

Catalytic activation of β-arrestin by GPCRs

(2018) Kelsie Eichel et al.   NATURE

Light-activated protein interaction with high spatial subcellular confinement

(2018) Lorena Benedetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mathematical Model of the Phosphoinositide Pathway

(2018) Daniel V. Olivença et al.   Scientific Reports

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

(2018) James P Zewe et al.   eLife

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

(2018) Hsin-Yung Yen et al.   NATURE

PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K

(2017) Mouhannad Malek et al.   MOLECULAR CELL

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

(2017) Mian Cao et al.   NEURON

Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion

(2017) Joshua A. Lees et al.   SCIENCE

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

(2017) Andrea L. Marat et al.   SCIENCE

Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System

(2017) Kexin Zhao et al.   Cell Reports

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

(2017) Alexander M Walter et al.   eLife

Comprehensive and Quantitative Analysis of Polyphosphoinositide Species by Shotgun Lipidomics Revealed Their Alterations in db/db Mouse Brain

(2016) Chunyan Wang et al.   ANALYTICAL CHEMISTRY

Touché! STARD3 and STARD3NL tether the ER to endosomes

(2016) Léa P. Wilhelm et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

Dynamics of Phosphoinositide-Dependent Signaling in Sympathetic Neurons

(2016) M. Kruse et al.   JOURNAL OF NEUROSCIENCE

Control of plasma membrane lipid homeostasis by the extended synaptotagmins

(2016) Yasunori Saheki et al.   NATURE CELL BIOLOGY

The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease

(2016) Michael J. Berridge   PHYSIOLOGICAL REVIEWS

Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence

(2016) Dongil Keum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi

(2016) Corinne Stoetzel et al.   Nature Communications

PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

(2016) Yevgeniya A Mironova et al.   eLife

PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium

(2016) Ángel Pérez-Lara et al.   eLife

Detection and manipulation of phosphoinositides

(2015) Olof Idevall-Hagren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polyphosphoinositide binding domains: Key to inositol lipid biology

(2015) Gerald R.V. Hammond et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphoinositides: Lipids with informative heads and mastermind functions in cell division

(2015) Clothilde Cauvin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mendelian disorders of PI metabolizing enzymes

(2015) Leopoldo Staiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ER contact sites direct late endosome transport

(2015) Ruud H. Wijdeven et al.   BIOESSAYS

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Chemotaxis of a model organism: progress with Dictyostelium

(2015) John ME Nichols et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

Mutations in Nature Conferred a High Affinity Phosphatidylinositol 4,5-Bisphosphate-binding Site in Vertebrate Inwardly Rectifying Potassium Channels

(2015) Qiong-Yao Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions

(2015) Chi-Lun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI(3,5)P2controls endosomal branched actin dynamics by regulating cortactin–actin interactions

(2015) Nan Hyung Hong et al.   JOURNAL OF CELL BIOLOGY

Barriers to the free diffusion of proteins and lipids in the plasma membrane

(2015) William S. Trimble et al.   JOURNAL OF CELL BIOLOGY

Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels

(2015) Carmen A. Ufret-Vincenty et al.   JOURNAL OF GENERAL PHYSIOLOGY

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

(2015) Jeremy M. Baskin et al.   NATURE CELL BIOLOGY

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis

(2015) Li Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

(2015) K. Rostislavleva et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled

(2015) Jian Hu et al.   Nature Communications

First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors

(2014) D. Sarker et al.   CLINICAL CANCER RESEARCH

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

(2014) Irene Franco et al.   DEVELOPMENTAL CELL

Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels

(2014) Naveen Bojjireddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

Nerve Growth Factor Sensitizes Adult Sympathetic Neurons to the Proinflammatory Peptide Bradykinin

(2014) O. Vivas et al.   JOURNAL OF NEUROSCIENCE

The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization

(2014) Brittany D. Wright et al.   NEURON

Idelalisib — A PI3Kδ Inhibitor for B-Cell Cancers

(2014) David A. Fruman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of PI3K/AKT-related PIP5K1  and the discovery of its selective inhibitor for treatment of advanced prostate cancer

(2014) J. Semenas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current

(2014) E. J. Dickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AP2 controls clathrin polymerization with a membrane-activated switch

(2014) B. T. Kelly et al.   SCIENCE

Specificity and Commonality of the Phosphoinositide-Binding Proteome Analyzed by Quantitative Mass Spectrometry

(2014) Stephanie Jungmichel et al.   Cell Reports

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

(2014) Ramiro Nández et al.   eLife

Phosphatidylinositol 5-phosphate: A nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics

(2013) Julien Viaud et al.   BIOESSAYS

Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors

(2013) Brooke M. Emerling et al.   CELL

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

(2013) SoHui Kim et al.   EMBO REPORTS

Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model

(2013) Li Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae

(2013) K. Suzuki et al.   JOURNAL OF CELL SCIENCE

Quantitative properties and receptor reserve of the DAG and PKC branch of Gq-coupled receptor signaling

(2013) Björn H. Falkenburger et al.   JOURNAL OF GENERAL PHYSIOLOGY

Quantitative properties and receptor reserve of the IP3and calcium branch of Gq-coupled receptor signaling

(2013) Eamonn J. Dickson et al.   JOURNAL OF GENERAL PHYSIOLOGY

DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination

(2013) R. Noseda et al.   JOURNAL OF NEUROSCIENCE

Joubert syndrome: congenital cerebellar ataxia with the molar tooth

(2013) Marta Romani et al.   LANCET NEUROLOGY

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

(2013) Kelly Devereaux et al.   PLoS One

Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development

(2013) A. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions

(2013) Chi-Lun Chang et al.   Cell Reports

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

(2013) Steffany A. L. Bennett et al.   Frontiers in Physiology

The Chemical Biology of Phosphoinositide 3-Kinases

(2012) Matthias P. Wymann et al.   CHEMBIOCHEM

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding

(2012) Vsevolod Telezhkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular KCNQ (Kv7) Potassium Channels as Common Signaling Intermediates and Therapeutic Targets in Cerebral Vasospasm

(2012) Bharath K. Mani et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity

(2012) Fubito Nakatsu et al.   JOURNAL OF CELL BIOLOGY

Regulation of voltage-gated potassium channels by PI(4,5)P2

(2012) Martin Kruse et al.   JOURNAL OF GENERAL PHYSIOLOGY

KCNQ Channels Determine Serotonergic Modulation of Ventral Surface Chemoreceptors and Respiratory Drive

(2012) J. M. Hawryluk et al.   JOURNAL OF NEUROSCIENCE

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

(2012) S. N. Zolov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP)

(2012) T. Kurokawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide isoforms determine compartment-specific ion channel activity

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic control of phosphoinositide metabolism

(2012) O. Idevall-Hagren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

(2012) G. R. V. Hammond et al.   SCIENCE

Synaptic Vesicle Endocytosis

(2012) Y. Saheki et al.   Cold Spring Harbor Perspectives in Biology

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Phosphoinositide Function in Cytokinesis

(2011) Julie A. Brill et al.   CURRENT BIOLOGY

A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

(2011) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

(2011) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

(2011) Jonathan Clark et al.   NATURE METHODS

Conditional Peripheral Membrane Proteins: Facing up to Limited Specificity

(2011) Katarina Moravcevic et al.   STRUCTURE

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

(2010) Andrew Manford et al.   EMBO JOURNAL

ArPIKfyve Regulates Sac3 Protein Abundance and Turnover

(2010) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Phosphoinositide and Ca2+Signals Mediating Receptor Specificity toward Neuronal Ca2+Channels

(2010) Oleg Zaika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of PIP2metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells

(2010) Björn H. Falkenburger et al.   JOURNAL OF GENERAL PHYSIOLOGY

The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

(2010) Junko Sasaki et al.   NATURE

Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

(2010) Byung-Chang Suh et al.   NEURON

Channelopathies linked to plasma membrane phosphoinositides

(2010) Diomedes E. Logothetis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling

(2010) Z. Szentpetery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide phosphatases in cell biology and disease

(2010) Yang Liu et al.   PROGRESS IN LIPID RESEARCH

Divide and ProsPer: The emerging role of PtdIns3P in cytokinesis

(2010) Ioannis P. Nezis et al.   TRENDS IN CELL BIOLOGY

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

Neural KCNQ (Kv7) channels

(2009) David A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1

(2009) Ivan Ivetac et al.   EMBO REPORTS

KCNQ Modulators Reveal a Key Role for KCNQ Potassium Channels in Regulating the Tone of Rat Pulmonary Artery Smooth Muscle

(2009) S. Joshi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Analysis of Phosphatidylinositol-4,5-Bisphosphate Signaling in Cerebellar Purkinje Spines

(2008) Sherry-Ann Brown et al.   BIOPHYSICAL JOURNAL

PIKfyve: Partners, significance, debates and paradoxes

(2008) A SHISHEVA   CELL BIOLOGY INTERNATIONAL

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse

(2008) Natsuko Jin et al.   EMBO JOURNAL

Voltage-sensing phosphatase: actions and potentials

(2008) Yasushi Okamura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

(2008) Diego E Berman et al.   NATURE NEUROSCIENCE