The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures

Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture

(2018) Chen Zheng et al.   CYTOTECHNOLOGY

Development of hyper osmotic resistant CHO host cells for enhanced antibody production

(2018) Yasuharu Kamachi et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform

(2018) Vania Bertrand et al.   JOURNAL OF BIOTECHNOLOGY

Improved process robustness, product quality and biological efficacy of an anti-CD52 monoclonal antibody upon pH shift in Chinese hamster ovary cell perfusion culture

(2018) Chen Zheng et al.   PROCESS BIOCHEMISTRY

The effect of culture temperature on the aggregation of recombinant TNFR-Fc is regulated by the PERK-eIF2a pathway in CHO cells

(2018) Kai Wang et al.   PROTEIN AND PEPTIDE LETTERS

The Increasingly Human and Profitable Monoclonal Antibody Market

(2018) António L. Grilo et al.   TRENDS IN BIOTECHNOLOGY

Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at +5 °C

(2017) Y. Leblanc et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Optimal Synthetic Glycosylation of a Therapeutic Antibody

(2016) Thomas B. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elucidating the effects of pH shift on IgG1 monoclonal antibody acidic charge variant levels in Chinese hamster ovary cell cultures

(2016) Panpan Xie et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors

(2016) Beate Hintersteiner et al.   mAbs

Culture temperature modulates monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures

(2015) Xintao Zhang et al.   BIOTECHNOLOGY LETTERS

Effect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells

(2014) Jong Kwang Hong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Increased CHO cell fed-batch monoclonal antibody production using the autophagy inhibitor 3-MA or gradually increasing osmolality

(2014) S. Soroush Nasseri et al.   BIOCHEMICAL ENGINEERING JOURNAL

Capacity planning for batch and perfusion bioprocesses across multiple biopharmaceutical facilities

(2013) Cyrus C. Siganporia et al.   BIOTECHNOLOGY PROGRESS

Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production

(2013) Soo Min Noh et al.   Current Opinion in Chemical Engineering

Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty

(2012) James Pollock et al.   BIOTECHNOLOGY AND BIOENGINEERING

Expression of anti-apoptotic 30Kc6 gene inhibiting hyperosmotic pressure-induced apoptosis in antibody-producing Chinese hamster ovary cells

(2012) Zesong Wang et al.   PROCESS BIOCHEMISTRY

Fucose content of monoclonal antibodies can be controlled by culture medium osmolality for high antibody-dependent cellular cytotoxicity

(2011) Yoshinobu Konno et al.   CYTOTECHNOLOGY

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Transcriptomic responses to sodium chloride-induced osmotic stress: A study of industrial fed-batch CHO cell cultures

(2010) Duan Shen et al.   BIOTECHNOLOGY PROGRESS

Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture

(2009) Young Kue Han et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Hyperosmotic Stress in Murine Hybridoma Cells: Effects on Antibody Transcription, Translation, Posttranslational Processing, and the Cell Cycle

(2004) Zhe Sun et al.   BIOTECHNOLOGY PROGRESS