Elucidating the effects of pH shift on IgG1 monoclonal antibody acidic charge variant levels in Chinese hamster ovary cell cultures

Culture temperature modulates monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures

(2015) Xintao Zhang et al.   BIOTECHNOLOGY LETTERS

Cell culture media supplementation of bioflavonoids for the targeted reduction of acidic species charge variants on recombinant therapeutic proteins

(2015) Patrick Hossler et al.   BIOTECHNOLOGY PROGRESS

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture

(2015) Shohei Kishishita et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Effect of ambient light on monoclonal antibody product quality during small-scale mammalian cell culture process in clear glass bioreactors

(2014) Mary Mallaney et al.   BIOTECHNOLOGY PROGRESS

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

(2014) Marija Ivarsson et al.   JOURNAL OF BIOTECHNOLOGY

What's fueling the biotech engine—2012 to 2013

(2014) Saurabh (Rob) Aggarwal   NATURE BIOTECHNOLOGY

Effect of culture pH on recombinant antibody production by a new human cell line, F2N78, grown in suspension at 33.0 °C and 37.0 °C

(2013) Jin Seok Seo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform

(2011) Efren Pacis et al.   BIOTECHNOLOGY AND BIOENGINEERING

Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography

(2011) Taylor Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing

(2010) Melody Trexler-Schmidt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mechanism of antibody reduction in cell culture production processes

(2010) Yung-Hsiang Kao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

(2009) Boxu Yan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Long-term operation of depth filter perfusion systems (DFPS) for monoclonal antibody production using recombinant CHO cells: Effect of temperature, pH, and dissolved oxygen

(2008) Joon Chul Lee et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Enhanced Production of Monomeric Interferon-β by CHO Cells through the Control of Culture Conditions

(2005) J. Rodriguez et al.   BIOTECHNOLOGY PROGRESS