Fucose content of monoclonal antibodies can be controlled by culture medium osmolality for high antibody-dependent cellular cytotoxicity

Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0

(2011) Béatrice Teylaert et al.   BMC BIOTECHNOLOGY

Influence of pH on Heat-Induced Aggregation and Degradation of Therapeutic Monoclonal Antibodies

(2010) Tomoyoshi Ishikawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Prevention of Stirring-Induced Microparticle Formation in Monoclonal Antibody Solutions

(2010) Tomoyoshi Ishikawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Defining process design space for monoclonal antibody cell culture

(2010) Susan Fugett Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

(2010) Xiaowei Zhang et al.   BIOTECHNOLOGY LETTERS

Enhancement of antibody production by the addition of Coenzyme-Q10

(2010) Yoshinobu Konno et al.   CYTOTECHNOLOGY

Characterization of a Monoclonal Antibody Cell Culture Production Process Using a Quality by Design Approach

(2010) Brian Horvath et al.   MOLECULAR BIOTECHNOLOGY

Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies

(2010) Wendy S. Putnam et al.   TRENDS IN BIOTECHNOLOGY

Recombinant plasma proteins

(2010) T. Burnouf   VOX SANGUINIS

Rapid production of recombinant human IgG With improved ADCC effector function in a transient expression system

(2009) Patrick H.C. van Berkel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Responses of GS-NS0 Myeloma cells to osmolality: Cell growth, intracellular mass metabolism, energy metabolism, and antibody production

(2009) Liang Zhao et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Emerging trends in plasma-free manufacturing of recombinant protein therapeutics expressed in mammalian cells

(2009) Leopold Grillberger et al.   Biotechnology Journal

Enhanced interferon-β production by CHO cells through elevated osmolality and reduced culture temperature

(2009) Young Kue Han et al.   BIOTECHNOLOGY PROGRESS

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Estimation of dissolved carbon dioxide stripping in a large bioreactor using model medium

(2009) Naoki Matsunaga et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

The art of antibody process development

(2008) David E. Steinmeyer et al.   DRUG DISCOVERY TODAY

Decrease in antithrombin III fucosylation by expressing GDP-fucose transporter siRNA in Chinese hamster ovary cells

(2008) Takeshi Omasa et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Pronounced Alterations of Cellular Metabolism and Structure Due to Hyper- or Hypo-Osmosis

(2008) Lei Mao et al.   JOURNAL OF PROTEOME RESEARCH

Influence of a Reduced CO2 Environment on the Secretion Yield, Potency and N-Glycan Structures of Recombinant Thyrotropin from CHO Cells

(2008) João Ezequiel Oliveira et al.   MOLECULAR BIOTECHNOLOGY

Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study

(2005) Marie M. Zhu et al.   BIOTECHNOLOGY PROGRESS

Hyperosmotic Stress in Murine Hybridoma Cells: Effects on Antibody Transcription, Translation, Posttranslational Processing, and the Cell Cycle

(2004) Zhe Sun et al.   BIOTECHNOLOGY PROGRESS