Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Asymmetric Transfer and Pressure Hydrogenation with Earth-Abundant Transition Metal Catalysts

(2018) Zhenfeng Zhang et al.   CHINESE JOURNAL OF CHEMISTRY

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

(2018) Shishir M. Pant et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nickel-Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and Benzhydrazide

(2016) Peng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Asymmetric Reductive Amination for the Synthesis of Chiral β-Arylamines

(2016) Haizhou Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Synthesis of EnolizableN-Sulfonyl Ketimines Under Microwave Irradiation

(2016) Pablo Ortiz et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Hydrogenation of Diarylmethanimines for Synthesis of Chiral Diarylmethylamines

(2016) Duanyang Kong et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Transfer Hydrogenation of Polar Double Bonds by Macrocyclic Iron(II)/(NH)2P2 Catalysts

(2016) Raphael Bigler et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer’s disease models

(2016) Hisae Nishioka et al.   Scientific Reports

Exploiting Metal–Ligand Bifunctional Reactions in the Design of Iron Asymmetric Hydrogenation Catalysts

(2015) Robert H. Morris   ACCOUNTS OF CHEMICAL RESEARCH

Nickel-Catalyzed Asymmetric Transfer Hydrogenation of Hydrazones and Other Ketimines

(2015) Haiyan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Transfer Hydrogenation of Imines: Recent Advances

(2015) Francisco Foubelo et al.   CHEMICAL RECORD

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction for Conformational Constraint

(2015) Lewis D. Pennington et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relay Iron/Chiral Brønsted Acid Catalysis: Enantioselective Hydrogenation of Benzoxazinones

(2015) Liang-Qiu Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative Catalysis with Iron and a Chiral Brønsted Acid for Asymmetric Reductive Amination of Ketones

(2014) Shaolin Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Intramolecular Oxidative Coupling Involving Double C(sp2)–H Bonds for the Synthesis of Annulated Biaryl Sultams

(2014) Joydev K. Laha et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Regiocontrolled Domino Synthesis of N-Sulfonyl Dihydrophenanthridines and Dihydrodibenzo[c,e]azepines: Control over the Formation of Biaryl Sultams in the Intramolecular Direct Arylation

(2014) Joydev K. Laha et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron(II) Complexes Containing Unsymmetrical P–N–P′ Pincer Ligands for the Catalytic Asymmetric Hydrogenation of Ketones and Imines

(2014) Paraskevi O. Lagaditis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Catalytic Asymmetric Reductive Amination of Simple Aromatic Ketones

(2013) Mingxin Chang et al.   ORGANIC LETTERS

Amine(imine)diphosphine Iron Catalysts for Asymmetric Transfer Hydrogenation of Ketones and Imines

(2013) W. Zuo et al.   SCIENCE

Brønsted Acid Activation Strategy in Transition-Metal Catalyzed Asymmetric Hydrogenation of N-Unprotected Imines, Enamines, and N-Heteroaromatic Compounds

(2012) Zhengkun Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric homogeneous hydrogenations at scale

(2012) David J. Ager et al.   CHEMICAL SOCIETY REVIEWS

Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs

(2012) Pablo Etayo et al.   CHEMICAL SOCIETY REVIEWS

Discovery of Highly Potent Human Deoxyuridine Triphosphatase Inhibitors Based on the Conformation Restriction Strategy

(2012) Seiji Miyahara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in Medicinal Chemistry of Sulfonamides. Rational Design as Anti-Tumoral, Anti-Bacterial and Anti-Inflammatory Agents

(2012) Syed Shoaib Ahmad Shah et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Asymmetric Transfer Hydrogenation of Ketimines Using Well-Defined Iron(II)-Based Precatalysts Containing a PNNP Ligand

(2012) Alexandre A. Mikhailine et al.   ORGANIC LETTERS

Hydrogenation of imino bonds with half-sandwich metal catalysts

(2011) Chao Wang et al.   CHEMICAL COMMUNICATIONS

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

(2011) Neil A. Strotman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

(2010) Thomas C. Nugent et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Synthesis of Amines: General, Efficient Iron-Catalyzed Asymmetric Transfer Hydrogenation of Imines

(2010) Shaolin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Reductive Amination of α-Branched Ketones

(2010) Vijay N. Wakchaure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

(2010) Michel Gallant et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Phosphinyl Imine Chemistry (I): Design and Synthesis of Novel N-Phosphinyl Imines and their Application to Asymmetric aza-Henry Reaction

(2010) Suresh Pindi et al.   Chemical Biology & Drug Design

Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines

(2010) Jian-Hua Xie et al.   CHEMICAL REVIEWS

Iridium−Monodentate Phosphoramidite-Catalyzed Asymmetric Hydrogenation of Substituted Benzophenone N−H Imines

(2010) Guohua Hou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist

(2010) F. G. Gervais et al.   MOLECULAR PHARMACOLOGY

Bifunctional Catalysis: Direct Reductive Amination of Aliphatic Ketones with an Iridium-Phosphate Catalyst

(2010) Barbara Villa-Marcos et al.   MOLECULES

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

(2010) Kevin W. Gillman et al.   ACS Medicinal Chemistry Letters

Direct Asymmetric Reductive Amination

(2009) Dietrich Steinhuebel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal−Brønsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

(2009) Chaoqun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzothiazoline: Highly Efficient Reducing Agent for the Enantioselective Organocatalytic Transfer Hydrogenation of Ketimines

(2009) Chen Zhu et al.   ORGANIC LETTERS

Instantaneous Deprotection of Tosylamides and Esters with SmI2/Amine/Water

(2009) Tobias Ankner et al.   ORGANIC LETTERS

A novel antagonist of prostaglandin D2blocks the locomotion of eosinophils and basophils

(2008) J. F. Royer et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Enantioselective Synthesis of Cyclic Sulfamidates via Pd-Catalyzed Hydrogenation

(2008) You-Qing Wang et al.   ORGANIC LETTERS

Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

(2008) Laura Rubio-Pérez et al.   ORGANIC LETTERS