Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 7, Pages 2763-2768Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b00085
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Funding
- Federal Ministry of Education and Research (BMBF)
- State of Mecklenburg-Vorpommern
- Alexander von Humboldt Foundation
- National Science Foundation for Young Scientists of China [21202053]
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An asymmetric hydrogenation reaction of benzoxazinones has been accomplished via a relay iron/chiral Bronsted acid catalysis. This approach provides a variety of chiral dihydrobenzoxazinones in good to high yields (75-96%) and enantioselectivities (up to 98:2 er). It is noteworthy that challenging 3-alkyl-substituted substrates underwent highly enantioselective reduction. A key to success is the utilization of a nonchiral phosphine ligand to reduce disadvantageous background reactions through tuning the catalytic activity of Fe-3(CO)(12).
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