Generation of genetically engineered non-human primate models of brain function and neurological disorders

The common marmoset monkey: avenues for exploring the prenatal, placental, and postnatal mechanisms in developmental programming of pediatric obesity

(2018) Laren Riesche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer

(2018) Zhen Liu et al.   CELL

Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination

(2018) Yiqiang Cui et al.   CELL RESEARCH

Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing

(2018) Xuan Yao et al.   CELL RESEARCH

Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates

(2018) Hideyuki Okano et al.   CURRENT OPINION IN NEUROBIOLOGY

Investigating the spatiotemporal characteristics of the deoxyhemoglobin-related and deoxyhemoglobin-unrelated functional hemodynamic response across cortical layers in awake marmosets

(2018) Cecil Chern-Chyi Yen et al.   NEUROIMAGE

Gene Editing on Center Stage

(2018) Rasmus O. Bak et al.   TRENDS IN GENETICS

Transgenic Mouse Models in Cancer Research

(2018) Ursa Lampreht Tratar et al.   Frontiers in Oncology

An overview of nonhuman primates in aging research

(2017) Julie A. Mattison et al.   EXPERIMENTAL GERONTOLOGY

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

Correction of a pathogenic gene mutation in human embryos

(2017) Hong Ma et al.   NATURE

Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

(2017) Zenpei Shimatani et al.   NATURE BIOTECHNOLOGY

Highly efficient RNA-guided base editing in mouse embryos

(2017) Kyoungmi Kim et al.   NATURE BIOTECHNOLOGY

Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets (Callithrix jacchus )

(2017) Yoshiyuki Hirano et al.   NMR IN BIOMEDICINE

Highly efficient and precise base editing in discarded human tripronuclear embryos

(2017) Guanglei Li et al.   Protein & Cell

Correction of β-thalassemia mutant by base editor in human embryos

(2017) Puping Liang et al.   Protein & Cell

TALEN-based generation of a cynomolgus monkey disease model for human microcephaly

(2016) Qiong Ke et al.   CELL RESEARCH

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing

(2016) Kenya Sato et al.   Cell Stem Cell

Anatomical and functional neuroimaging in awake, behaving marmosets

(2016) Afonso C. Silva   Developmental Neurobiology

Obesity and Aging in Humans and Nonhuman Primates: A Mini-Review

(2016) Kelli L. Vaughan et al.   GERONTOLOGY

Two-photon imaging of cerebral hemodynamics and neural activity in awake and anesthetized marmosets

(2016) Thom P. Santisakultarm et al.   JOURNAL OF NEUROSCIENCE METHODS

Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

(2016) Zhen Liu et al.   NATURE

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

(2016) Yunqing Ma et al.   NATURE METHODS

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

(2016) Gaelen T Hess et al.   NATURE METHODS

Brain/MINDS: A Japanese National Brain Project for Marmoset Neuroscience

(2016) Hideyuki Okano et al.   NEURON

In vivo whole brain, cellular and molecular imaging in nonhuman primate models of neuropathology

(2016) Lieven Huang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gene targeting, genome editing: from Dolly to editors

(2016) Wenfang Tan et al.   TRANSGENIC RESEARCH

Generation of transgenic marmosets expressing genetically encoded calcium indicators

(2016) Jung Eun Park et al.   Scientific Reports

Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body

(2016) Yasunari Seita et al.   Scientific Reports

Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells

(2015) Yongchang Chen et al.   Cell Stem Cell

CRISPR/Cas9-mediatedDax1knockout in the monkey recapitulates human AHC-HH

(2015) Yu Kang et al.   HUMAN MOLECULAR GENETICS

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

(2015) Yongchang Chen et al.   HUMAN MOLECULAR GENETICS

Brains, Genes, and Primates

(2015) Juan Carlos Izpisua Belmonte et al.   NEURON

Brain/MINDS: brain-mapping project in Japan

(2015) H. Okano et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Progressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood

(2015) Anthony W. S. Chan et al.   PLoS One

Artificial cloning of domestic animals

(2015) Carol L. Keefer   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline transmission in transgenic Huntington's disease monkeys

(2015) Sean Moran et al.   THERIOGENOLOGY

Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases

(2015) Sarah J. Mitchell et al.   Annual Review of Animal Biosciences

Early Parkinson's disease symptoms in  -synuclein transgenic monkeys

(2015) Y. Niu et al.   HUMAN MOLECULAR GENETICS

A two years longitudinal study of a transgenic Huntington disease monkey

(2014) Anthony WS Chan et al.   BMC NEUROSCIENCE

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys

(2014) Yongchang Chen et al.   CELL RESEARCH

One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system

(2014) Haifeng Wan et al.   CELL RESEARCH

Regulatory Principles of Pluripotency: From the Ground State Up

(2014) Jamie A. Hackett et al.   Cell Stem Cell

Generation of Naive Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts

(2014) Riguo Fang et al.   Cell Stem Cell

TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

(2014) Hailiang Liu et al.   Cell Stem Cell

Cell-based therapies for Huntington's disease

(2014) Yiju Chen et al.   DRUG DISCOVERY TODAY

Interpretation ofNOTCH3mutations in the diagnosis of CADASIL

(2014) Julie W Rutten et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Marmosets are stars of Japan’s ambitious brain project

(2014) David Cyranoski   NATURE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Generation of a monkey with MECP2 mutations by TALEN-based gene targeting

(2014) Zhen Liu et al.   Neuroscience Bulletin

Reversal of Cellular Phenotypes in Neural Cells Derived from Huntington’s Disease Monkey-Induced Pluripotent Stem Cells

(2014) Richard L. Carter et al.   Stem Cell Reports

The Marmoset as a Model of Aging and Age-Related Diseases

(2013) S. D. Tardif et al.   ILAR JOURNAL

Progress and Prospects for Genetic Modification of Nonhuman Primate Models in Biomedical Research

(2013) A. W. S. Chan   ILAR JOURNAL

Reshaping the transcriptional frontier: Epigenetics and somatic cell nuclear transfer

(2013) Charles R. Long et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Metabolic consequences of the early onset of obesity in common marmoset monkeys

(2013) Michael L. Power et al.   Obesity

The Usefulness and Challenges of Transgenic Mouse Models in the Study of Alzheimers Disease

(2012) Donna M. Wilcock   CNS & Neurological Disorders-Drug Targets

The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update

(2012) Kelly R Bales   Expert Opinion on Drug Discovery

Pluripotent Stem Cells Models for Huntington's Disease: Prospects and Challenges

(2012) Richard L. Carter et al.   Journal of Genetics and Genomics

Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors

(2012) Yongchang Chen et al.   Journal of Genetics and Genomics

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Pathogenic Cellular Phenotypes are Germline Transmissible in a Transgenic Primate Model of Huntington's Disease

(2012) Kittiphong Putkhao et al.   STEM CELLS AND DEVELOPMENT

Cloning of non-human primates: the road "less traveled by"

(2011) Michelle L. Sparman et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Transgenic mouse models of multiple sclerosis

(2010) Tanja Scheikl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reprogramming Huntington Monkey Skin Cells into Pluripotent Stem Cells

(2010) Anthony W.S. Chan et al.   Cellular Reprogramming

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

(2010) Ting Li et al.   NUCLEIC ACIDS RESEARCH

Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector

(2010) Yuyu Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic primate offspring

(2009) Gerald Schatten et al.   NATURE

Marmoset model takes centre stage

(2009) David Cyranoski   NATURE

Generation of transgenic non-human primates with germline transmission

(2009) Erika Sasaki et al.   NATURE

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE