TALEN-based generation of a cynomolgus monkey disease model for human microcephaly

Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

(2016) Zhen Liu et al.   NATURE

Molecular genetics of human primary microcephaly: an overview

(2015) Muhammad Faheem et al.   BMC Medical Genomics

SLC1A4mutations cause a novel disorder of intellectual disability, progressive microcephaly, spasticity and thin corpus callosum

(2015) G. Heimer et al.   CLINICAL GENETICS

A case report: Autosomal recessive microcephaly caused by a novel mutation in MCPH1 gene

(2015) Soudeh Ghafouri-Fard et al.   GENE

Brains, Genes, and Primates

(2015) Juan Carlos Izpisua Belmonte et al.   NEURON

MCPH1: a window into brain development and evolution

(2015) Jeremy N. Pulvers   Frontiers in Cellular Neuroscience

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system

(2014) Haifeng Wan et al.   CELL RESEARCH

TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

(2014) Hailiang Liu et al.   Cell Stem Cell

Common marmoset as a new model animal for neuroscience research and genome editing technology

(2014) Noriyuki Kishi et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Generation of a monkey with MECP2 mutations by TALEN-based gene targeting

(2014) Zhen Liu et al.   Neuroscience Bulletin

Investigating microcephaly

(2013) C. G. Woods et al.   ARCHIVES OF DISEASE IN CHILDHOOD

TALENoffer: genome-wide TALEN off-target prediction

(2013) Jan Grau et al.   BIOINFORMATICS

Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans

(2013) Lei Shi et al.   BMC BIOLOGY

DNA damage response in microcephaly development of MCPH1 mouse model

(2013) Zhong-Wei Zhou et al.   DNA REPAIR

MCPH1 deletion in a newborn with severe microcephaly and premature chromosome condensation

(2013) Ruthann B. Pfau et al.   European Journal of Medical Genetics

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Novel mutations c.[5121_5122insAG]+[6859C>T] of the SPG11 gene associated with cerebellum hypometabolism in a Chinese case of hereditary spastic paraplegia with thin corpus callosum

(2013) Jing Ma et al.   PARKINSONISM & RELATED DISORDERS

Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media

(2013) Jing Chen et al.   PLoS One

Influence of Passive Muscle Tension on Electromechanical Delay in Humans

(2013) Lilian Lacourpaille et al.   PLoS One

The Available Time Window for Embryo Transfer in the Rhesus Monkey (Macaca mulatta)

(2012) YONGCHANG CHEN et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene

(2012) Lei Shi et al.   GENE

MCPH1 patient cells exhibit delayed release from DNA damage-induced G2/M checkpoint arrest 

(2011) Ioannis Gavvovidis et al.   CELL CYCLE

SET Nuclear Oncogene Associates with Microcephalin/MCPH1 and Regulates Chromosome Condensation

(2011) Justin W. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic engineering of human pluripotent cells using TALE nucleases

(2011) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway

(2011) Ralph Gruber et al.   NATURE CELL BIOLOGY

FSL

(2011) Mark Jenkinson et al.   NEUROIMAGE

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

(2011) Claudio Mussolino et al.   NUCLEIC ACIDS RESEARCH

Autosomal recessive primary microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum

(2011) Saqib Mahmood et al.   Orphanet Journal of Rare Diseases

Craniosynostosis-microcephaly with chromosomal breakage and other abnormalities is caused by a truncating MCPH1 mutation and is allelic to premature chromosomal condensation syndrome and primary autosomal recessive microcephaly type 1

(2010) Muhammad Farooq et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A clinical and molecular genetic study of 112 Iranian families with primary microcephaly

(2010) H. Darvish et al.   JOURNAL OF MEDICAL GENETICS

Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function

(2010) Marc Trimborn et al.   PLoS One

Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector

(2010) Yuyu Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice

(2010) Yulong Liang et al.   PLoS Genetics

The human brain in numbers: a linearly scaled-up primate brain

(2009) Suzana Herculano-Houzel   Frontiers in Human Neuroscience

A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation

(2009) Mark W. Richards et al.   JOURNAL OF MOLECULAR BIOLOGY

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE