Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment
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Title
Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 5, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2014-08-28
DOI
10.3389/fimmu.2014.00409
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Note: Only part of the references are listed.- Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
- (2014) Mako Nakaya et al. IMMUNITY
- Glucose Activates TORC2-Gad8 Protein via Positive Regulation of the cAMP/cAMP-dependent Protein Kinase A (PKA) Pathway and Negative Regulation of the Pmk1 Protein-Mitogen-activated Protein Kinase Pathway
- (2014) Adiel Cohen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Anti-Inflammatory Effects of FTY720 against Viral-Induced Immunopathology: Role of Drug-Induced Conversion of T Cells to Become Foxp3+ Regulators
- (2014) S. Sehrawat et al. JOURNAL OF IMMUNOLOGY
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex
- (2014) Emily B Heikamp et al. NATURE IMMUNOLOGY
- TOR Complex 2-Ypk1 Signaling Maintains Sphingolipid Homeostasis by Sensing and Regulating ROS Accumulation
- (2014) Brad J. Niles et al. Cell Reports
- The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
- (2013) Alfred Csibi et al. CELL
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity
- (2013) D. C. Saucillo et al. JOURNAL OF IMMUNOLOGY
- Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
- (2013) Chuan Wu et al. NATURE
- Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
- (2013) Markus Kleinewietfeld et al. NATURE
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
- (2013) Pengda Liu et al. NATURE CELL BIOLOGY
- Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
- (2013) Yoko Kidani et al. NATURE IMMUNOLOGY
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Fueling Immunity: Insights into Metabolism and Lymphocyte Function
- (2013) E. L. Pearce et al. SCIENCE
- Matched and mismatched metabolic fuels in lymphocyte function
- (2013) Alfredo Caro-Maldonado et al. SEMINARS IN IMMUNOLOGY
- Differing Effects of Rapamycin or Calcineurin Inhibitor on T-Regulatory Cells in Pediatric Liver and Kidney Transplant Recipients
- (2012) T. Akimova et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
- (2012) Anne Le et al. Cell Metabolism
- T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
- (2012) Naganari Ohkura et al. IMMUNITY
- Tryptophan hydroxylase-1 regulates immune tolerance and inflammation
- (2012) Elizabeth C. Nowak et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Foxp3 Expression Is Required for the Induction of Therapeutic Tissue Tolerance
- (2012) F. S. Regateiro et al. JOURNAL OF IMMUNOLOGY
- TIM-3 Regulates Innate Immune Cells To Induce Fetomaternal Tolerance
- (2012) L. Chabtini et al. JOURNAL OF IMMUNOLOGY
- Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
- (2012) Xueliang Gao et al. MOLECULAR CELL
- Transcription factor Foxp3 and its protein partners form a complex regulatory network
- (2012) Dipayan Rudra et al. NATURE IMMUNOLOGY
- Sirtuins as regulators of metabolism and healthspan
- (2012) Riekelt H. Houtkooper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- (2012) E. T. Clambey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer
- (2012) Barbara Chaneton et al. TRENDS IN BIOCHEMICAL SCIENCES
- TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway
- (2012) Qi Zhang et al. Journal of Molecular Cell Biology
- IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
- (2012) Richard Metz et al. OncoImmunology
- On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: Biochemical mechanisms and regulatory control
- (2011) Michael A. Sirover BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β
- (2011) Frederico S. Regateiro et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
- (2011) Guoliang Cui et al. JOURNAL OF CLINICAL INVESTIGATION
- Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance
- (2011) Adrian R. Kendal et al. JOURNAL OF EXPERIMENTAL MEDICINE
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
- (2011) A. Clayton et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
- (2011) Maria T Pallotta et al. NATURE IMMUNOLOGY
- Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
- (2011) Xiang-Ping Yang et al. NATURE IMMUNOLOGY
- Estrogen-related receptor- is a metabolic regulator of effector T-cell activation and differentiation
- (2011) R. D. Michalek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biomarkers of Transplantation Tolerance: More Hopeful than Helpful?
- (2011) Stephen P. Cobbold et al. Frontiers in Immunology
- Moonlighting proteins: An intriguing mode of multitasking
- (2010) Daphne H.E.W. Huberts et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs
- (2010) Jonghwan Kim et al. CELL
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- The diverse functions of GAPDH: Views from different subcellular compartments
- (2010) Carlos Tristan et al. CELLULAR SIGNALLING
- mTOR signalling and metabolic regulation of T cell differentiation
- (2010) Christian Peter et al. CURRENT OPINION IN IMMUNOLOGY
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- (2010) Pascale G. Charest et al. DEVELOPMENTAL CELL
- MAPK signalling in cellular metabolism: stress or wellness?
- (2010) Helmuth Gehart et al. EMBO REPORTS
- Tolerogenicity is not an absolute property of a dendritic cell
- (2010) Claire A. Farquhar et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
- (2010) Xiaofeng Sun et al. GASTROENTEROLOGY
- An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
- (2010) Claudio Procaccini et al. IMMUNITY
- Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways
- (2010) Keunwook Lee et al. IMMUNITY
- Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
- (2010) Sybille Mazurek INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling
- (2010) Irantzu Tato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
- (2010) Yohsuke Harada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Peroxisome Proliferator-Activated Receptor and Agonists Together with TGF- Convert Human CD4+CD25- T Cells into Functional Foxp3+ Regulatory T Cells
- (2010) J. Lei et al. JOURNAL OF IMMUNOLOGY
- Ecto-5'-Nucleotidase (CD73) Attenuates Allograft Airway Rejection through Adenosine 2A Receptor Stimulation
- (2010) T. Ohtsuka et al. JOURNAL OF IMMUNOLOGY
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
- (2010) Weiming Ouyang et al. NATURE IMMUNOLOGY
- The Cell Cycle Time of CD8+ T Cells Responding In Vivo Is Controlled by the Type of Antigenic Stimulus
- (2010) Heesik Yoon et al. PLoS One
- Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling
- (2010) Aimee J. Marko et al. PLoS One
- The REM phase of gene regulation
- (2010) Matthias W. Hentze et al. TRENDS IN BIOCHEMICAL SCIENCES
- MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
- (2009) C. V. Dang et al. CLINICAL CANCER RESEARCH
- Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity
- (2009) C. Schmidl et al. GENOME RESEARCH
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
- (2009) Greg M. Delgoffe et al. IMMUNITY
- mTOR signaling at a glance
- (2009) M. Laplante et al. JOURNAL OF CELL SCIENCE
- TGF- Promotes Th17 Cell Development through Inhibition of SOCS3
- (2009) H. Qin et al. JOURNAL OF IMMUNOLOGY
- The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
- (2009) Guangwei Liu et al. NATURE IMMUNOLOGY
- Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
- (2009) Agnes Machnik et al. NATURE MEDICINE
- Infectious tolerance via the consumption of essential amino acids and mTOR signaling
- (2009) S. P. Cobbold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells
- (2008) M Sitkovsky et al. BRITISH JOURNAL OF PHARMACOLOGY
- LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
- (2008) Steven J. Bensinger et al. CELL
- Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α
- (2008) Jeremy Ben-Shoshan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Myc's broad reach
- (2008) M. Eilers et al. GENES & DEVELOPMENT
- The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells
- (2008) Sokol Haxhinasto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo
- (2008) Jonghwan Kim et al. PLoS One
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
- (2008) S. Sauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- ERRα: a metabolic function for the oldest orphan
- (2008) Josep A. Villena et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
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