Article
Cell Biology
Adam Feher, Marianna Pocsi, Ferenc Papp, Tibor G. Szanto, Agota Csoti, Zsolt Fejes, Bela Nagy, Balazs Nemes, Zoltan Varga
Summary: This study identified multiple voltage-gated sodium channels in the plasma membrane of human B cells using electrophysiological and molecular biology methods. The detected sodium currents showed sensitivity between TTX-sensitive and TTX-insensitive channels, suggesting the co-existence of multiple Na(V)1 subtypes. The results also supported the functional role of these channels in shaping and maintaining the resting membrane potential.
Article
Biochemistry & Molecular Biology
Kirsten L. Mcmahon, Henrik O'Brien, Christina I. Schroeder, Jennifer R. Deuis, Dhananjeyan Venkatachalam, Di Huang, Brad R. Green, Pradip K. Bandyopadhyay, Qing Li, Mark Yandell, Helena Safavi-Hemami, Baldomero M. Olivera, Irina Vetter, Samuel D. Robinson
Summary: This study identified new mu-conotoxins from species of the subgenera Textilia and Afonsoconus and investigated their selectivity at human Na-V channels using RNA-seq and DNA analysis techniques.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Tatsuya Suzuki, Seiji Yamato
Summary: Oxazosulfyl is a novel insecticide that acts by blocking voltage-gated sodium channels in insects, resulting in paralysis. This discovery sheds light on the mode of action of oxazosulfyl as a potential pest control agent in rice fields.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Nolan M. Dvorak, Cynthia M. Tapia, Timothy J. Baumgartner, Jully Singh, Fernanda Laezza, Aditya K. Singh
Summary: This study reveals the selective modulatory effects of Wee1 kinase inhibitor on Na(v)1.2 channel activity, emphasizing the importance of cellular signaling pathways in fine-tuning neuronal excitability.
Article
Anesthesiology
Jane E. Hartung, Jamie K. Moy, Emanuel Loeza-Alcocer, Vidhya Nagarajan, Ruth Jostock, Thomas Christoph, Wolfgang Schroeder, Michael S. Gold
Summary: This study characterized the high voltage-activated calcium currents in human and rat sensory neurons, revealing differences between the two species. The results showed significant differences in current density, sensitivity, and inhibition between human and rat neurons.
Article
Chemistry, Medicinal
Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sebastien Dutertre
Summary: This study focuses on the synthesis and characterization of two novel α-Conotoxins obtained from two species endemic to the Marquesas Islands, Conus gauguini and Conus adamsonii. GaIA showed potent inhibitory activity at the muscle nAChR (IC50 = 38 nM), while AdIA was most potent at the neuronal α6/3β2β3 subtype (IC50 = 177 nM). This study contributes to a better understanding of the structure-activity relationships of α-Conotoxins, providing insights for the design of more selective tools.
Review
Chemistry, Medicinal
James R. Groome
Summary: This article reviews the study of marine toxins, particularly on their actions on sodium ion channels regulated by transmembrane voltage and neurotransmitters. The focus is on the diverse conotoxin peptides and their potential applications in evolutionary relationships, biological actions, disease therapy, and understanding the structure of ion channels at the atomic level.
Article
Computer Science, Information Systems
Jorge Perez-Bailon, Belen Calvo, Nicolas Medrano
Summary: This paper presents the design and postlayout simulation results of a capacitor-less low dropout (LDO) regulator fully integrated in a low-cost standard 180 nm CMOS technology, which regulates the output voltage at 1.2 V from a 3.3 to 1.3 V battery over a -40 to 120 degrees C temperature range. Achieving ultralow power consumption and minimum area consumption, including a reference voltage V-ref = 0.4 V, the regulator uses a high-gain dynamically biased folded-based error amplifier topology optimized for low-voltage operation to enhance regulation-fast transient performance trade-off.
Article
Neurosciences
Neville M. Ngum, Muhammad Y. A. Aziz, Liaque Mohammed Latif, Richard J. Wall, Ian R. Duce, Ian R. Mellor
Summary: This study reveals the dominant expression of Na(V)1.7 isoform of voltage-gated sodium channels in human TE671 cell line and highlights its significance in the study of analgesic drugs and pain.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Zoja Selimi, Jean-Sebastien Rougier, Hugues Abriel, Jan P. P. Kucera
Summary: Cardiac voltage-gated sodium (Na+) channels play a crucial role in myocardial electrical excitation. Single-channel recordings indicate that these channels exhibit functional interactions and coupled gating. However, the analysis of such recordings often involves manual interventions, leading to potential bias. In this study, an automated pipeline was developed to de-trend and idealize single-channel currents, revealing weak or no functional interactions in wild-type Na(v)1.5 channels.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Food Science & Technology
Rafael Gonzalez-Cano, M. Carmen Ruiz-Cantero, Miriam Santos-Caballero, Carlos Gomez-Navas, Miguel A. Tejada, Francisco R. Nieto
Summary: Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels, exhibiting promising analgesic effects in treating neuropathic pain. However, it can also produce major toxic effects at therapeutic doses, necessitating careful consideration for clinical use. Research indicates potential therapeutic effects of other natural toxins that selectively block TTX-sensitive VGSCs for alleviating neuropathic pain.
Article
Engineering, Environmental
Sukhyung Lee, Bonhyeop Koo, Seokbum Kang, Hongkyung Lee, Hochun Lee
Summary: By developing a Na+ ion concentrated LNCIL electrolyte, the voltage stability and Na dendrite protection of Na metal batteries have been successfully improved. The addition of HFE lowers viscosity, improves separator wettability, facilitates Na+ ion transport, and promotes the involvement of dual anions to suppress Na dendrite growth.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Xiuping Yin, Zhixiu Lu, Jing Wang, Xiaochen Feng, Swagata Roy, Xiangsi Liu, Yong Yang, Yufeng Zhao, Jiujun Zhang
Summary: This study reports an ultrafast sodium storage throughout the whole-voltage region by rationally adjusting the physical parameters of hard carbons through a ZnO-assisted etching strategy. It is found that the storage capacity of sodium is related to the p-band center of the carbon material, and the balance between adsorption energy and diffusion barrier is critical in improving charge-storage kinetics. The prepared hard carbon microspheres exhibit high rate performance and unprecedented electrochemical performance at extremely low temperature.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Kunyuan Zuo, Tingting Dai, Qiang Guo, Zongtao Wang, Mengzhen Du, Helin Wang, Ailing Tang, Erjun Zhou, Qing Guo, Youdi Zhang
Summary: In this study, we developed two A2-A1-D-A1-A2-type nonfullerene acceptors (NFAs) to achieve high-voltage and high-performance organic photovoltaics (OPVs). Chlorine substitution at different positions in the polymer not only affected the photophysical properties but also resulted in different power conversion efficiencies (PCEs) and energy loss (Eloss). The result showed that chlorination is an effective method to modulate the properties of NFAs for high-voltage and high-performance OPVs.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Engineering, Environmental
Zixuan Wang, Liming Liu, Yousheng Wang, Yajie Ma, Zigan Yang, Meixiu Wan, Hongbin Zhu, Tahmineh Mahmoudi, Yoon-Bong Hahn, Yaohua Mai
Summary: A green and simple antisolvent-mediator is developed to stabilize the perovskite active layer, facilitate crystal growth, and passivate defects. The resulting perovskite solar cells show high power conversion efficiency and open-circuit voltage, as well as long-term stability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Jeffrey R. McArthur, Rocio K. Finol-Urdaneta, David J. Adams
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Chemistry, Medicinal
Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Vyacheslav S. Korkosh, Sun Huang, Denis McMaster, Robert Glavica, Denis B. Tikhonov, Boris S. Zhorov, Robert J. French
Article
Neurosciences
Alexander A. Harper, Katrina Rimmer, Jhansi Dyavanapalli, Jeffrey R. McArthur, David J. Adams
Article
Pharmacology & Pharmacy
Karen Luna-Ramirez, Agota Csoti, Jeffrey R. McArthur, Yanni K. Y. Chin, Raveendra Anangi, Rosby del Carmen Najera, Lourival D. Possani, Glenn F. King, Gyorgy Panyi, Haibo Yu, David J. Adams, Rocio K. Finol-Urdaneta
BIOCHEMICAL PHARMACOLOGY
(2020)
Review
Chemistry, Medicinal
Rocio K. Finol-Urdaneta, Aleksandra Belovanovic, Milica Micic-Vicovac, Gemma K. Kinsella, Jeffrey R. McArthur, Ahmed Al-Sabi
Article
Neurosciences
Amy J. Hulme, Jeffrey R. McArthur, Simon Maksour, Sara Miellet, Lezanne Ooi, David J. Adams, Rocio K. Finol-Urdaneta, Mirella Dottori
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Pharmacology & Pharmacy
Jeffrey R. McArthur, Nehan R. Munasinghe, Rocio K. Finol-Urdaneta, David J. Adams, Macdonald J. Christie
Summary: Research has shown that Pn3a produces analgesic effects by inhibiting HVA Ca(v), with enhanced inhibition observed when co-administered with opioid agonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Joshua P. Torres, Zhenjian Lin, Maren Watkins, Paula Florez Salcedo, Robert P. Baskin, Shireen Elhabian, Helena Safavi-Hemami, Dylan Taylor, Jortan Tun, Gisela P. Concepcion, Noel Saguil, Angel A. Yanagihara, Yixin Fang, Jeffrey R. McArthur, Han-Shen Tae, Rocio K. Finol-Urdaneta, B. Duygu Ozpolat, Baldomero M. Olivera, Eric W. Schmidt
Summary: Venomous cone snails use small molecules in their venom to mimic natural mating pheromones of their prey polychaete worms, evoking mating behavior. These specialized metabolites are species-specific and structurally diverse, indicating that cone snails may adopt various prey-hunting strategies facilitated by small molecules. In the phenomenon of aggressive mimicry, C. imperialis uses metabolically stable mimics of prey pheromones, highlighting a unique aspect of biological mimicry in chemical ecology.
Article
Cell & Tissue Engineering
Serena Viventi, Stefano Frausin, Sara E. Howden, Shiang Y. Lim, Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Kwaku Dad Abu-Bonsrah, Wayne Ng, Jason Ivanusic, Lachlan Thompson, Mirella Dottori
Summary: Friedreich ataxia is characterized by degeneration of sensory neurons due to low Frataxin levels. Transplantation of stem cell-derived progenitors into DRG regions showed survival and differentiation, expressing neuronal markers. This study suggests the potential of using stem cells for cell replacement therapy in treating neurodegeneration in FRDA.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Clifford TeBay, Jeffrey R. McArthur, Melissa Mangala, Nicholas Kerr, Stewart Heitmann, Matthew D. Perry, Monique J. Windley, Jamie Vandenberg, Adam P. Hill
Summary: Hydroxychloroquine, chloroquine, and azithromycin have been proposed as drugs to treat COVID-19, but they carry a risk of proarrhythmia. Factors such as electrolyte imbalances, acidosis, and temperature can alter the potency of these drugs and increase the risk of proarrhythmia. In vitro screening and in silico simulations can help guide the preclinical screening and clinical management of patients receiving these drugs.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Rocio K. Finol-Urdaneta, Rebekah Ziegman, Zoltan Dekan, Jeffrey R. McArthur, Stewart Heitmann, Karen Luna-Ramirez, Han-Shen Tae, Alexander Mueller, Hana Starobova, Yanni K. -Y. Chin, Joshua S. Wingerd, Eivind A. B. Undheim, Ben Cristofori-Armstrong, Adam P. Hill, Volker Herzig, Glenn F. King, Irina Vetter, Lachlan Rash, David J. Adams, Paul F. Alewood
Summary: The venom of the King Baboon spider contains a cysteine-rich peptide that can induce pain by targeting multiple ion channels, leading to hyperexcitability in pain-sensing neurons. This peptide may be an evolutionary adaptation for pain induction in defensive venoms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Anuja R. Bony, Jeffrey R. McArthur, Akari Komori, Ann R. Wong, Andrew Hung, David J. Adams
Summary: This study identifies the binding site of analgesic a-conotoxins on the human GABAB receptor and the key residues involved in the interaction. Furthermore, the study explores the sensitivity of other mutants to the analgesic a-conotoxins.
MOLECULAR PHARMACOLOGY
(2022)
Article
Biology
Jeffrey R. McArthur, Jierong Wen, Andrew Hung, Rocio K. Finol-Urdaneta, David J. Adams, Henry M. Colecraft
Summary: The spider venom peptide inhibitor Pn3a has been identified as a subtype-selective inhibitor of the Ca(V)3.3 T-type calcium channel. It modifies the gating of Ca(V)3.3 and decreases its currents by shifting the voltage dependence of activation. This study expands our understanding of T-type calcium channel pharmacology and highlights the potential use of Pn3a as a molecular tool in studying the physiological roles of Ca(V)3.3 channels.
Article
Neurosciences
Neven Maksemous, Claire D. Blayney, Heidi G. Sutherland, Robert A. Smith, Rod A. Lea, Kim Ngan Tran, Omar Ibrahim, Jeffrey R. McArthur, Larisa M. Haupt, M. Zameel Cader, Rocio K. Finol-Urdaneta, David J. Adams, Lyn R. Griffiths
Summary: By analyzing whole-exome sequencing data, we found that rare variants in the CACNA1I gene may be associated with the occurrence of hemiplegic migraine.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Meeting Abstract
Biophysics
Anuja R. Bony, Jeffrey R. McArthur, Rocio K. Finol-Urdaneta, David J. Adams
BIOPHYSICAL JOURNAL
(2020)