Biomarkers for cognitive impairment in Lewy body disorders: Status and relevance for clinical trials

Biomarkers for cognitive dysfunction in Parkinson's disease

(2018) Lorraine V. Kalia   PARKINSONISM & RELATED DISORDERS

Abnormalities of Cortical Neural Synchronization Mechanisms in Subjects with Mild Cognitive Impairment due to Alzheimer’s and Parkinson’s Diseases: An EEG Study

(2017) Claudio Babiloni et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

(2017) David J Irwin et al.   LANCET NEUROLOGY

Cognitive decline in Parkinson disease

(2017) Dag Aarsland et al.   Nature Reviews Neurology

Corpus callosal atrophy and associations with cognitive impairment in Parkinson disease

(2017) Jennifer G. Goldman et al.   NEUROLOGY

Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls

(2017) Brit Mollenhauer et al.   NEUROLOGY

Frontotemporal dementia with the V337M MAPT mutation

(2017) Salvatore Spina et al.   NEUROLOGY

CSF A-SYNUCLEIN CORRELATES WITH FDG-PET IN EARLY PARKINSON'S DISEASE

(2016) Per Selnes et al.   Alzheimers & Dementia

Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's

(2016) Ganqiang Liu et al.   ANNALS OF NEUROLOGY

AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies

(2016) Kejal Kantarci et al.   ANNALS OF NEUROLOGY

Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer’s Disease and Parkinson’s Disease Dementia?

(2016) Grazia D. Femminella et al.   JOURNAL OF ALZHEIMERS DISEASE

White matter hyperintensities, cerebrospinal amyloid-β and dementia in Parkinson's disease

(2016) Yaroslau Compta et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Patterns of cortical thinning in nondemented Parkinson's disease patients

(2016) Carme Uribe et al.   MOVEMENT DISORDERS

Biomarkers for dementia and mild cognitive impairment in Parkinson's disease

(2016) Manuel Delgado-Alvarado et al.   MOVEMENT DISORDERS

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Monitoring of 30 marker candidates in early Parkinson disease as progression markers

(2016) Brit Mollenhauer et al.   NEUROLOGY

Autopsy validation of 123 I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB

(2016) Alan J. Thomas et al.   NEUROLOGY

Failure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results

(2016) Thomas J. Hwang et al.   JAMA Internal Medicine

Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases

(2016) Stephen N. Gomperts et al.   JAMA Neurology

Amyloid PET Imaging in Lewy Body Disorders

(2015) Paul Donaghy et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Baseline and longitudinal grey matter changes in newly diagnosed Parkinson’s disease: ICICLE-PD study

(2015) Elijah Mak et al.   BRAIN

White Matter Hyperintensities and Mild Cognitive Impairment in Parkinson's Disease

(2015) Elijah Mak et al.   JOURNAL OF NEUROIMAGING

Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?

(2015) Gordon W. Duncan et al.   MOVEMENT DISORDERS

Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies

(2015) Laura Bonanni et al.   NEUROBIOLOGY OF AGING

Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals

(2015) Sophie E. Winder-Rhodes et al.   NEUROBIOLOGY OF AGING

Correlation between decreased CSF α-synuclein and Aβ1–42 in Parkinson disease

(2015) Chandana Buddhala et al.   NEUROBIOLOGY OF AGING

Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease

(2015) David C. Bäckström et al.   JAMA Neurology

PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 (florbenazine) in patients with Alzheimer’s disease and Lewy body disorders

(2014) Andrew Siderowf et al.   BMC Neurology

Genetic impact on cognition and brain function in newly diagnosed Parkinson’s disease: ICICLE-PD study

(2014) Cristina Nombela et al.   BRAIN

The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease

(2014) M. K. Sunwoo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson’s disease

(2014) Yaroslau Compta et al.   JOURNAL OF NEUROLOGY

Pragmatic issues in biomarker evaluation for targeted therapies in cancer

(2014) Armand de Gramont et al.   Nature Reviews Clinical Oncology

Initial cognitive decline is associated with cortical thinning in early Parkinson disease

(2014) J. B. Pereira et al.   NEUROLOGY

CSF A 42 predicts early-onset dementia in Parkinson disease

(2014) G. Alves et al.   NEUROLOGY

Longitudinal follow-up of SWEDD subjects in the PRECEPT Study

(2014) K. Marek et al.   NEUROLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hippocampal volume and white matter disease in the prediction of dementia in Parkinson's disease

(2014) Nagaendran Kandiah et al.   PARKINSONISM & RELATED DISORDERS

Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease

(2014) Oskar Hansson et al.   Alzheimers Research & Therapy

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease

(2014) Lucilla Parnetti et al.   Frontiers in Aging Neuroscience

Longitudinal changes in task-evoked brain responses in Parkinson's disease patients with and without mild cognitive impairment

(2014) Urban Ekman et al.   Frontiers in Neuroscience

Mild cognitive impairment in Parkinson's disease is associated with a distributed pattern of brain white matter damage

(2013) Federica Agosta et al.   HUMAN BRAIN MAPPING

Cognitive deficits in mild Parkinson's disease are associated with distinct areas of grey matter atrophy

(2013) E. Mak et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cortical thinning is associated with disease stages and dementia in Parkinson's disease

(2013) M. Zarei et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Exploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease

(2013) J. E. Lee et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cerebrospinal fluid Aβ levels correlate with structural brain changes in Parkinson's disease

(2013) Mona K. Beyer et al.   MOVEMENT DISORDERS

Magnetic resonance imaging: A biomarker for cognitive impairment in Parkinson's disease?

(2013) Gordon W. Duncan et al.   MOVEMENT DISORDERS

White matter microstructure deteriorates across cognitive stages in Parkinson disease

(2013) T. R. Melzer et al.   NEUROLOGY

Combined dementia-risk biomarkers in Parkinson's disease: A prospective longitudinal study

(2013) Yaroslau Compta et al.   PARKINSONISM & RELATED DISORDERS

Pattern of Regional Cortical Thinning Associated with Cognitive Deterioration in Parkinson’s Disease

(2013) Javier Pagonabarraga et al.   PLoS One

Serum epidermal growth factor predicts cognitive functions in early, drug-naive Parkinson’s disease patients

(2012) Maria Teresa Pellecchia et al.   JOURNAL OF NEUROLOGY

Functional brain activity and presynaptic dopamine uptake in patients with Parkinson's disease and mild cognitive impairment: a cross-sectional study

(2012) Urban Ekman et al.   LANCET NEUROLOGY

Entorhinal cortex atrophy differentiates Parkinson's disease patients with and without dementia

(2012) Jennifer G. Goldman et al.   MOVEMENT DISORDERS

Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease

(2012) Bernard Ravina et al.   MOVEMENT DISORDERS

Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia

(2012) S. N. Gomperts et al.   NEUROLOGY

Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia

(2012) Yaroslau Compta et al.   PARKINSONISM & RELATED DISORDERS

Neurodegeneration Across Stages of Cognitive Decline in Parkinson Disease

(2011) Daniel Weintraub   ARCHIVES OF NEUROLOGY

Cognitive status correlates with white matter alteration in Parkinson's disease

(2011) Takaaki Hattori et al.   HUMAN BRAIN MAPPING

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Different CSF β-amyloid processing in Alzheimer’s and Creutzfeldt–Jakob disease

(2011) Brit Mollenhauer et al.   JOURNAL OF NEURAL TRANSMISSION

Grey matter atrophy in cognitively impaired Parkinson's disease

(2011) Tracy R Melzer et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

(2011) Henryk Barthel et al.   LANCET NEUROLOGY

The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status

(2011) Sook K. Song et al.   MOVEMENT DISORDERS

MDS task force on mild cognitive impairment in Parkinson's disease: Critical review of PD-MCI

(2011) Irene Litvan et al.   MOVEMENT DISORDERS

Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status

(2011) Seo Hee Choi et al.   NEUROBIOLOGY OF AGING

CSF α-synuclein does not differentiate between parkinsonian disorders

(2011) M.B. Aerts et al.   NEUROBIOLOGY OF AGING

Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease

(2010) Alice S. Chen-Plotkin et al.   ANNALS OF NEUROLOGY

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

(2010) Min Shi et al.   ANNALS OF NEUROLOGY

Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies

(2010) Brit Mollenhauer et al.   Biomarkers in Medicine

CSF amyloid-  and tau proteins, and cognitive performance, in early and untreated Parkinson's Disease: the Norwegian ParkWest study

(2010) G. Alves et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo

(2010) J. C. Klein et al.   NEUROLOGY

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

CSF amyloid   1-42 predicts cognitive decline in Parkinson disease

(2010) A. Siderowf et al.   NEUROLOGY

Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson’s disease

(2010) James B. Leverenz et al.   PARKINSONISM & RELATED DISORDERS

Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: A123I-FP-CIT SPECT study

(2009) Francesco Roselli et al.   MOVEMENT DISORDERS

Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson's disease

(2009) Yaroslau Compta et al.   MOVEMENT DISORDERS

Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET

(2009) H. Shimada et al.   NEUROLOGY

Cerebrospinal Fluid Biomarkers in Parkinson's Disease with Dementia and Dementia with Lewy Bodies

(2008) Lucilla Parnetti et al.   BIOLOGICAL PSYCHIATRY

Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography

(2008) P Edison et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Imaging amyloid deposition in Lewy body diseases

(2008) S. N. Gomperts et al.   NEUROLOGY

Uric acid associates with cognition in Parkinson's disease

(2008) Tua Annanmaki et al.   PARKINSONISM & RELATED DISORDERS