Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders

When Overgrowth Bumps Into Cancer: The PTEN-Opathies

(2013) JESSICA MESTER et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Macrocephaly as a Clinical Indicator of Genetic Subtypes in Autism

(2013) Steven Klein et al.   Autism Research

Exosomes as a novel way of interneuronal communication

(2013) Mathilde Chivet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein

(2013) Craig N. Lumb et al.   BIOPHYSICAL JOURNAL

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

More than one ring to bind them all: Recent insights into the structure of the axon

(2013) Gianluca Gallo   Developmental Neurobiology

Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly

(2013) Judith A Hobert et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Nuclear trafficking of Pten after brain injury leads to neuron survival not death

(2013) Choo-Peng Goh et al.   EXPERIMENTAL NEUROLOGY

Differential Role of PTEN Phosphatase in Chemotactic Growth Cone Guidance

(2013) Steven J. Henle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drebrin contains a cryptic F-actin–bundling activity regulated by Cdk5 phosphorylation

(2013) Daniel C. Worth et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

PTEN knockdown alters dendritic spine/protrusion morphology, not density

(2013) Michael E. Haws et al.   JOURNAL OF COMPARATIVE NEUROLOGY

PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons

(2013) K. J. Christie et al.   JOURNAL OF NEUROSCIENCE

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury

(2013) K. Zukor et al.   JOURNAL OF NEUROSCIENCE

PIP3 Regulates Spinule Formation in Dendritic Spines during Structural Long-Term Potentiation

(2013) Y. Ueda et al.   JOURNAL OF NEUROSCIENCE

Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries

(2013) S. Zhang et al.   JOURNAL OF NEUROSCIENCE

Cowden Syndrome and the PTEN Hamartoma Tumor Syndrome: Systematic Review and Revised Diagnostic Criteria

(2013) R. Pilarski et al.   JNCI-Journal of the National Cancer Institute

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium

(2013) H N Nguyen et al.   ONCOGENE

Optogenetic Control of PIP3: PIP3 Is Sufficient to Induce the Actin-Based Active Part of Growth Cones and Is Regulated via Endocytosis

(2013) Toshiyuki Kakumoto et al.   PLoS One

Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer

(2013) Kathleen Gabriel et al.   PLoS One

Phosphorylation of the Actin Binding Protein Drebrin at S647 Is Regulated by Neuronal Activity and PTEN

(2013) Patricia Kreis et al.   PLoS One

Inhibition of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Decreases Rat Cortical Neuron Injury and Blood-Brain Barrier Permeability, and Improves Neurological Functional Recovery in Traumatic Brain Injury Model

(2013) Jun Ding et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration

(2013) W. K. A. Karunarathne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis

(2013) C. Hodakoski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

(2013) K. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

(2013) Prerna Malaney et al.   Scientific Reports

Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway

(2013) Keiichi Inoue et al.   PLoS Genetics

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

(2013) David Bolduc et al.   eLife

Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

(2013) Hyejung Won et al.   Frontiers in Molecular Neuroscience

Germline PIK3CA and AKT1 Mutations in Cowden and Cowden-like Syndromes

(2012) Mohammed S. Orloff et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional analysis of the protein phosphatase activity of PTEN

(2012) Xiaoqun Catherine Zhang et al.   BIOCHEMICAL JOURNAL

PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice

(2012) Y. Zhang et al.   BRAIN

PNUTS Functions as a Proto-Oncogene by Sequestering PTEN

(2012) S. Kavela et al.   CANCER RESEARCH

PTEN signaling in autism spectrum disorders

(2012) Jing Zhou et al.   CURRENT OPINION IN NEUROBIOLOGY

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

(2012) Jason Howitt et al.   JOURNAL OF CELL BIOLOGY

PTEN at a glance

(2012) Y. Shi et al.   JOURNAL OF CELL SCIENCE

A Phosphatidylinositol Lipids System, Lamellipodin, and Ena/VASP Regulate Dynamic Morphology of Multipolar Migrating Cells in the Developing Cerebral Cortex

(2012) S. Yoshinaga et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis

(2012) A. Amiri et al.   JOURNAL OF NEUROSCIENCE

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

(2012) L. Mao et al.   NEUROSCIENCE

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

(2012) Chandler L. Walker et al.   PLoS One

Membrane Association of the PTEN Tumor Suppressor: Molecular Details of the Protein-Membrane Complex from SPR Binding Studies and Neutron Reflection

(2012) Siddharth Shenoy et al.   PLoS One

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

(2012) T. R. Fenton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

(2012) P. Tibarewal et al.   Science Signaling

Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN

(2012) E. Terrien et al.   Science Signaling

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Regulation of the tumor suppressor PTEN by SUMO

(2012) J González-Santamaría et al.   Cell Death & Disease

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion

(2011) Lingyun Zu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Janine Kirby et al.   BRAIN

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia

(2011) Mirela Spillane et al.   Developmental Neurobiology

Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

(2011) Evelyne Lima-Fernandes et al.   EMBO JOURNAL

Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model

(2011) Jessica L Mester et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models

(2011) Andrii Domanskyi et al.   FASEB JOURNAL

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

(2011) Isabel Rodríguez-Escudero et al.   HUMAN MOLECULAR GENETICS

Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder, and Epilepsy

(2011) Sara Conti et al.   JOURNAL OF CHILD NEUROLOGY

Asymmetric PI(3,4,5)P3 and Akt Signaling Mediates Chemotaxis of Axonal Growth Cones

(2011) S. J. Henle et al.   JOURNAL OF NEUROSCIENCE

Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells

(2011) B. W. Luikart et al.   JOURNAL OF NEUROSCIENCE

Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration

(2011) Margaret Sperow et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells

(2011) J.-S. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility

(2011) Jae-Ick Kim et al.   NATURE NEUROSCIENCE

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome

(2011) Marjorie J. Lindhurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

(2011) J R Molina et al.   ONCOGENE

Different Conformations of Phosphatase and Tensin Homolog, Deleted on Chromosome 10 (PTEN) Protein within the Nucleus and Cytoplasm of Neurons

(2011) Vera L. Moncalero et al.   PLoS One

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains

(2011) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositides in Cell Architecture

(2011) A. Shewan et al.   Cold Spring Harbor Perspectives in Biology

Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly

(2010) Kim L. McBride et al.   Autism Research

PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression

(2010) Sandra Jurado et al.   EMBO JOURNAL

PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons

(2010) Ke Ning et al.   HUMAN MOLECULAR GENETICS

Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

(2010) Helene Maccario et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Semaphorin 4D/Plexin-B1 Stimulates PTEN Activity through R-Ras GTPase-activating Protein Activity, Inducing Growth Cone Collapse in Hippocampal Neurons

(2010) Izumi Oinuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nerve Growth Factor Induces Axonal Filopodia through Localized Microdomains of Phosphoinositide 3-Kinase Activity That Drive the Formation of Cytoskeletal Precursors to Filopodia

(2010) A. Ketschek et al.   JOURNAL OF NEUROSCIENCE

A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons

(2010) Ana Luisa Perdigoto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

(2010) Young-Don Kwak et al.   Molecular Neurodegeneration

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN

(2010) Jovana Drinjakovic et al.   NEURON

Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

(2010) Yuma Sonoda et al.   NEUROSCIENCE LETTERS

Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2

(2010) T. Mund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

(2010) R. B. Chagpar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutant form of PTEN linked to autism

(2010) Roberta E. Redfern et al.   PROTEIN SCIENCE

NovelPTENmutations in neurodevelopmental disorders and macrocephaly

(2009) A Orrico et al.   CLINICAL GENETICS

The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly

(2009) Elizabeth A Varga et al.   GENETICS IN MEDICINE

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

MyosinV controls PTEN function and neuronal cell size

(2009) Michiel T. van Diepen et al.   NATURE CELL BIOLOGY

PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane

(2009) Kristin L Arendt et al.   NATURE NEUROSCIENCE

Selective Deletion of PTEN in Dopamine Neurons Leads to Trophic Effects and Adaptation of Striatal Medium Spiny Projecting Neurons

(2009) Oscar Diaz-Ruiz et al.   PLoS One

Phosphorylation keeps PTEN phosphatase closed for business

(2009) A. H. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

PTEN Phosphatase Selectively Binds Phosphoinositides and Undergoes Structural Changes†

(2008) Roberta E. Redfern et al.   BIOCHEMISTRY

The nuclear affairs of PTEN

(2008) S. M. Planchon et al.   JOURNAL OF CELL SCIENCE

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

Understanding PTEN regulation: PIP2, polarity and protein stability

(2008) N R Leslie et al.   ONCOGENE

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

(2007) M.M. Fraser et al.   NEUROSCIENCE