Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders
出版年份 2014 全文链接
标题
Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders
作者
关键词
-
出版物
Frontiers in Molecular Neuroscience
Volume 7, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2014-04-01
DOI
10.3389/fnmol.2014.00023
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- When Overgrowth Bumps Into Cancer: The PTEN-Opathies
- (2013) JESSICA MESTER et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
- Macrocephaly as a Clinical Indicator of Genetic Subtypes in Autism
- (2013) Steven Klein et al. Autism Research
- Exosomes as a novel way of interneuronal communication
- (2013) Mathilde Chivet et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein
- (2013) Craig N. Lumb et al. BIOPHYSICAL JOURNAL
- RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
- (2013) Ralph Fritsch et al. CELL
- Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner
- (2013) A Bononi et al. CELL DEATH AND DIFFERENTIATION
- More than one ring to bind them all: Recent insights into the structure of the axon
- (2013) Gianluca Gallo Developmental Neurobiology
- Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly
- (2013) Judith A Hobert et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Nuclear trafficking of Pten after brain injury leads to neuron survival not death
- (2013) Choo-Peng Goh et al. EXPERIMENTAL NEUROLOGY
- Differential Role of PTEN Phosphatase in Chemotactic Growth Cone Guidance
- (2013) Steven J. Henle et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Drebrin contains a cryptic F-actin–bundling activity regulated by Cdk5 phosphorylation
- (2013) Daniel C. Worth et al. JOURNAL OF CELL BIOLOGY
- Extracellular vesicles: Exosomes, microvesicles, and friends
- (2013) Graça Raposo et al. JOURNAL OF CELL BIOLOGY
- PTEN knockdown alters dendritic spine/protrusion morphology, not density
- (2013) Michael E. Haws et al. JOURNAL OF COMPARATIVE NEUROLOGY
- PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons
- (2013) K. J. Christie et al. JOURNAL OF NEUROSCIENCE
- Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury
- (2013) K. Zukor et al. JOURNAL OF NEUROSCIENCE
- PIP3 Regulates Spinule Formation in Dendritic Spines during Structural Long-Term Potentiation
- (2013) Y. Ueda et al. JOURNAL OF NEUROSCIENCE
- Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries
- (2013) S. Zhang et al. JOURNAL OF NEUROSCIENCE
- Cowden Syndrome and the PTEN Hamartoma Tumor Syndrome: Systematic Review and Revised Diagnostic Criteria
- (2013) R. Pilarski et al. JNCI-Journal of the National Cancer Institute
- MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes
- (2013) Juxiang Cao et al. MOLECULAR CELL
- mTOR complexes in neurodevelopmental and neuropsychiatric disorders
- (2013) Mauro Costa-Mattioli et al. NATURE NEUROSCIENCE
- Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium
- (2013) H N Nguyen et al. ONCOGENE
- Optogenetic Control of PIP3: PIP3 Is Sufficient to Induce the Actin-Based Active Part of Growth Cones and Is Regulated via Endocytosis
- (2013) Toshiyuki Kakumoto et al. PLoS One
- Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer
- (2013) Kathleen Gabriel et al. PLoS One
- Phosphorylation of the Actin Binding Protein Drebrin at S647 Is Regulated by Neuronal Activity and PTEN
- (2013) Patricia Kreis et al. PLoS One
- Inhibition of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Decreases Rat Cortical Neuron Injury and Blood-Brain Barrier Permeability, and Improves Neurological Functional Recovery in Traumatic Brain Injury Model
- (2013) Jun Ding et al. PLoS One
- Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
- (2013) L. Hedskog et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration
- (2013) W. K. A. Karunarathne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis
- (2013) C. Hodakoski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism
- (2013) K. Takeuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival
- (2013) B. D. Hopkins et al. SCIENCE
- Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress
- (2013) C. Bassi et al. SCIENCE
- Extracellular vesicles as mediators of neuron-glia communication
- (2013) Carsten Frühbeis et al. Frontiers in Cellular Neuroscience
- Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility
- (2013) Prerna Malaney et al. Scientific Reports
- Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway
- (2013) Keiichi Inoue et al. PLoS Genetics
- Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
- (2013) David Bolduc et al. eLife
- Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses
- (2013) Hyejung Won et al. Frontiers in Molecular Neuroscience
- Germline PIK3CA and AKT1 Mutations in Cowden and Cowden-like Syndromes
- (2012) Mohammed S. Orloff et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Functional analysis of the protein phosphatase activity of PTEN
- (2012) Xiaoqun Catherine Zhang et al. BIOCHEMICAL JOURNAL
- PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice
- (2012) Y. Zhang et al. BRAIN
- PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
- (2012) S. Kavela et al. CANCER RESEARCH
- PTEN signaling in autism spectrum disorders
- (2012) Jing Zhou et al. CURRENT OPINION IN NEUROBIOLOGY
- Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
- (2012) Jason Howitt et al. JOURNAL OF CELL BIOLOGY
- PTEN at a glance
- (2012) Y. Shi et al. JOURNAL OF CELL SCIENCE
- A Phosphatidylinositol Lipids System, Lamellipodin, and Ena/VASP Regulate Dynamic Morphology of Multipolar Migrating Cells in the Developing Cerebral Cortex
- (2012) S. Yoshinaga et al. JOURNAL OF NEUROSCIENCE
- Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis
- (2012) A. Amiri et al. JOURNAL OF NEUROSCIENCE
- The functions and regulation of the PTEN tumour suppressor
- (2012) Min Sup Song et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PI3K signalling: the path to discovery and understanding
- (2012) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke
- (2012) L. Mao et al. NEUROSCIENCE
- Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury
- (2012) Chandler L. Walker et al. PLoS One
- Membrane Association of the PTEN Tumor Suppressor: Molecular Details of the Protein-Membrane Complex from SPR Binding Studies and Neutron Reflection
- (2012) Siddharth Shenoy et al. PLoS One
- Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
- (2012) T. R. Fenton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity
- (2012) P. Tibarewal et al. Science Signaling
- Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN
- (2012) E. Terrien et al. Science Signaling
- The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells
- (2012) U. Putz et al. Science Signaling
- Regulation of the tumor suppressor PTEN by SUMO
- (2012) J González-Santamaría et al. Cell Death & Disease
- SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
- (2012) Jian Huang et al. Nature Communications
- Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion
- (2011) Lingyun Zu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis
- (2011) Janine Kirby et al. BRAIN
- Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner
- (2011) Min Sup Song et al. CELL
- The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia
- (2011) Mirela Spillane et al. Developmental Neurobiology
- Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins
- (2011) Evelyne Lima-Fernandes et al. EMBO JOURNAL
- Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model
- (2011) Jessica L Mester et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
- (2011) Andrii Domanskyi et al. FASEB JOURNAL
- A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
- (2011) Isabel Rodríguez-Escudero et al. HUMAN MOLECULAR GENETICS
- Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder, and Epilepsy
- (2011) Sara Conti et al. JOURNAL OF CHILD NEUROLOGY
- Asymmetric PI(3,4,5)P3 and Akt Signaling Mediates Chemotaxis of Axonal Growth Cones
- (2011) S. J. Henle et al. JOURNAL OF NEUROSCIENCE
- Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells
- (2011) B. W. Luikart et al. JOURNAL OF NEUROSCIENCE
- Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration
- (2011) Margaret Sperow et al. JOURNAL OF PHYSIOLOGY-LONDON
- Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells
- (2011) J.-S. Kim et al. MOLECULAR AND CELLULAR BIOLOGY
- Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
- (2011) Fang Sun et al. NATURE
- PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility
- (2011) Jae-Ick Kim et al. NATURE NEUROSCIENCE
- A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome
- (2011) Marjorie J. Lindhurst et al. NEW ENGLAND JOURNAL OF MEDICINE
- PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
- (2011) J R Molina et al. ONCOGENE
- Different Conformations of Phosphatase and Tensin Homolog, Deleted on Chromosome 10 (PTEN) Protein within the Nucleus and Cytoplasm of Neurons
- (2011) Vera L. Moncalero et al. PLoS One
- PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
- (2011) X. Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoinositides in Cell Architecture
- (2011) A. Shewan et al. Cold Spring Harbor Perspectives in Biology
- Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly
- (2010) Kim L. McBride et al. Autism Research
- PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
- (2010) Sandra Jurado et al. EMBO JOURNAL
- PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons
- (2010) Ke Ning et al. HUMAN MOLECULAR GENETICS
- Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress
- (2010) Helene Maccario et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Semaphorin 4D/Plexin-B1 Stimulates PTEN Activity through R-Ras GTPase-activating Protein Activity, Inducing Growth Cone Collapse in Hippocampal Neurons
- (2010) Izumi Oinuma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nerve Growth Factor Induces Axonal Filopodia through Localized Microdomains of Phosphoinositide 3-Kinase Activity That Drive the Formation of Cytoskeletal Precursors to Filopodia
- (2010) A. Ketschek et al. JOURNAL OF NEUROSCIENCE
- A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons
- (2010) Ana Luisa Perdigoto et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
- (2010) Young-Don Kwak et al. Molecular Neurodegeneration
- PTEN deletion enhances the regenerative ability of adult corticospinal neurons
- (2010) Kai Liu et al. NATURE NEUROSCIENCE
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- GSK3 signalling in neural development
- (2010) Eun-Mi Hur et al. NATURE REVIEWS NEUROSCIENCE
- E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN
- (2010) Jovana Drinjakovic et al. NEURON
- Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles
- (2010) Yuma Sonoda et al. NEUROSCIENCE LETTERS
- Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2
- (2010) T. Mund et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase
- (2010) R. B. Chagpar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A mutant form of PTEN linked to autism
- (2010) Roberta E. Redfern et al. PROTEIN SCIENCE
- NovelPTENmutations in neurodevelopmental disorders and macrocephaly
- (2009) A Orrico et al. CLINICAL GENETICS
- The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly
- (2009) Elizabeth A Varga et al. GENETICS IN MEDICINE
- Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice
- (2009) J. Zhou et al. JOURNAL OF NEUROSCIENCE
- MyosinV controls PTEN function and neuronal cell size
- (2009) Michiel T. van Diepen et al. NATURE CELL BIOLOGY
- PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
- (2009) Kristin L Arendt et al. NATURE NEUROSCIENCE
- Selective Deletion of PTEN in Dopamine Neurons Leads to Trophic Effects and Adaptation of Striatal Medium Spiny Projecting Neurons
- (2009) Oscar Diaz-Ruiz et al. PLoS One
- Phosphorylation keeps PTEN phosphatase closed for business
- (2009) A. H. Ross et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a
- (2009) B. Fine et al. SCIENCE
- PTEN Phosphatase Selectively Binds Phosphoinositides and Undergoes Structural Changes†
- (2008) Roberta E. Redfern et al. BIOCHEMISTRY
- The nuclear affairs of PTEN
- (2008) S. M. Planchon et al. JOURNAL OF CELL SCIENCE
- The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
- (2008) Min Sup Song et al. NATURE
- Understanding PTEN regulation: PIP2, polarity and protein stability
- (2008) N R Leslie et al. ONCOGENE
- A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
- (2008) M. Rahdar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
- (2008) K. K. Park et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started