Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement Regulation

Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation

(2015) Aikaterini Theodoraki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases

(2015) Markus A. Loeven et al.   MOLECULAR IMMUNOLOGY

Sweet escape: Sialic acids in tumor immune evasion

(2014) Christian Büll et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular Degeneration

(2014) Simon J. Clark et al.   JOURNAL OF IMMUNOLOGY

TSG-6 Inhibits Neutrophil Migration via Direct Interaction with the Chemokine CXCL8

(2014) D. P. Dyer et al.   JOURNAL OF IMMUNOLOGY

Structural basis for sialic acid–mediated self-recognition by complement factor H

(2014) Bärbel S Blaum et al.   Nature Chemical Biology

The sweet spot: defining virus–sialic acid interactions

(2014) Jennifer E. Stencel-Baerenwald et al.   NATURE REVIEWS MICROBIOLOGY

Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands

(2014) Stephen J. Perkins et al.   Frontiers in Immunology

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

Functional Anatomy of Complement Factor H

(2013) Elisavet Makou et al.   BIOCHEMISTRY

Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease

(2013) Ralf Schwörer et al.   CHEMISTRY-A EUROPEAN JOURNAL

The endothelial glycocalyx as a potential modifier of the hemolytic uremic syndrome

(2013) Margien G.S. Boels et al.   European Journal of Internal Medicine

Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions

(2013) S. J. Clark et al.   JOURNAL OF IMMUNOLOGY

The Role of Complement in Age-Related Macular Degeneration: Heparan Sulphate, a ZIP Code for Complement Factor H?

(2013) Alex Langford-Smith et al.   Journal of Innate Immunity

Properdin in complement activation and tissue injury

(2013) Allison M. Lesher et al.   MOLECULAR IMMUNOLOGY

Glyco-engineering 'super-self'

(2013) Matthew S Macauley et al.   Nature Chemical Biology

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

(2013) M. Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression

(2013) Angélica M. Gomes et al.   Biomed Research International

The Proteoglycan Glycomatrix: A Sugar Microenvironment Essential for Complement Regulation

(2013) Simon J. Clark et al.   Frontiers in Immunology

Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”

(2013) Lubna Kouser et al.   Frontiers in Immunology

Age-related impairment of endothelial progenitor cell migration correlates with structural alterations of heparan sulfate proteoglycans

(2012) Kate A. Williamson et al.   AGING CELL

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

Glycobiology of immune responses

(2012) Gabriel A. Rabinovich et al.   Annals of the New York Academy of Sciences

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx

(2012) Bettina Linnartz et al.   GLIA

Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate

(2012) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immobilization of Heparan Sulfate on Electrospun Meshes to Support Embryonic Stem Cell Culture and Differentiation

(2012) Kate A. Meade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice

(2012) Alexander Langford-Smith et al.   MOLECULAR THERAPY

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Allelic Variants of Complement Genes Associated with Dense Deposit Disease

(2011) M. A. Abrera-Abeleda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection

(2010) Sean Gill et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology

(2010) Simon J. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heparan sulfate glycomics: towards systems biology strategies: Figure 1

(2010) Jeremy E. Turnbull   BIOCHEMICAL SOCIETY TRANSACTIONS

Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina

(2010) Simon J. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

(2010) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease

(2009) Ilona B. Bruinsma et al.   ACTA NEUROPATHOLOGICA

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Sialic acids acquired byPseudomonas aeruginosaare involved in reduced complement deposition and siglec mediated host-cell recognition

(2009) Biswajit Khatua et al.   FEBS LETTERS

Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

(2009) Markus J. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome

(2009) Dorothea Orth et al.   JOURNAL OF IMMUNOLOGY

The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

(2009) V. P. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi

(2009) Igor dos S. Cestari et al.   MOLECULAR IMMUNOLOGY

Cancer resistance to complement-dependent cytotoxicity (CDC): Problem-oriented research and development

(2009) Dana Gancz et al.   MOLECULAR IMMUNOLOGY

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

(2009) Muriel C. Schneider et al.   NATURE

The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis

(2008) Claudia Kemper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE