New and Future Drug Development for Gastroesophageal Reflux Disease

A Randomized, Comparative Trial of a Potassium-Competitive Acid Blocker (AZD0865) and Esomeprazole for the Treatment of Patients With Nonerosive Reflux Disease

(2013) John Dent et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Novel Pharmaceutical Approaches to Reflux Disease

(2013) Usha Dutta et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

The effects of a novel metabotropic glutamate receptor 5 antagonist (AZD2066) on transient lower oesophageal sphincter relaxations and reflux episodes in healthy volunteers

(2012) W. O. Rohof et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Bioavailability and Tolerability of Combination Treatment With Revaprazan 200 mg + Itopride 150 mg: A Randomized Crossover Study in Healthy Male Korean Volunteers

(2012) Hee Youn Choi et al.   CLINICAL THERAPEUTICS

A Study on the Efficacy of Rebamipide for Patients with Proton Pump Inhibitor-Refractory Non-Erosive Reflux Disease

(2012) Kyoichi Adachi et al.   DIGESTIVE DISEASES AND SCIENCES

Burden of Gastrointestinal Disease in the United States: 2012 Update

(2012) Anne F. Peery et al.   GASTROENTEROLOGY

Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period

(2012) W O Rohof et al.   GUT

Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)

(2012) Yasuyoshi Arikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

The effect of once daily omeprazole and succinic acid (VECAM) vs once daily omeprazole on 24-h intragastric pH

(2012) Y. Chowers et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Localization of mGluR5, GABAB, GABAA, and cannabinoid receptors on the vago-vagal reflex pathway responsible for transient lower esophageal sphincter relaxation in humans: an immunohistochemical study

(2012) W. O. Rohof et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

(2011) A. L. Krarup et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Transient lower oesophageal sphincter relaxation reducers - have we hit a brick wall?

(2011) T. Hershcovici et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effect of rimonabant on oesophageal motor function in man

(2011) E. Scarpellini et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review: the treatment of noncardiac chest pain

(2011) T. Hershcovici et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease

(2011) F. Zerbib et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Arbaclofen Placarbil in GERD: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Nimish B Vakil et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Effect of Dexlansoprazole MR on Nocturnal Heartburn and GERD-Related Sleep Disturbances in Patients With Symptomatic GERD

(2011) Ronnie Fass et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Dexlansoprazole MR – A review

(2011) Tiberiu Hershcovici et al.   ANNALS OF MEDICINE

Alternative Therapeutic Approaches to Chronic Proton Pump Inhibitor Treatment

(2011) Ronnie Fass   Clinical Gastroenterology and Hepatology

Maintenance of Heartburn Relief After Step-Down From Twice-Daily Proton Pump Inhibitor to Once-Daily Dexlansoprazole Modified Release

(2011) Ronnie Fass et al.   Clinical Gastroenterology and Hepatology

Ilaprazole for the treatment of duodenal ulcer: a randomized, double-blind and controlled phase III trial

(2011) Ling Wang et al.   CURRENT MEDICAL RESEARCH AND OPINION

Gastro-Oesophageal Reflux Disease

(2011) Tiberiu Hershcovici et al.   DRUGS

Acid inhibition effect of ilaprazole on Helicobacter pylori-negative healthy volunteers: An open randomized cross-over study

(2011) Yi Qi DU et al.   Journal of Digestive Diseases

A Study Comparing the Antisecretory Effect of TAK-438, a Novel Potassium-Competitive Acid Blocker, with Lansoprazole in Animals

(2011) Y. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The lower esophageal sphincter

(2011) T. Hershcovici et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial

(2011) Bhupesh Dewan et al.   Gastroenterology Research and Practice

The pharmacodynamics and pharmacokinetics of S-tenatoprazole-Na 30 mg, 60 mg and 90 mg vs. esomeprazole 40 mg in healthy male subjects

(2010) R. H. HUNT et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Extraesophageal manifestations of gastroesophageal reflux disease: real or imagined?

(2010) John M Moore et al.   CURRENT OPINION IN GASTROENTEROLOGY

Prucalopride

(2010) James E. Frampton   DRUGS

Effects of Lesogaberan on Reflux and Lower Esophageal Sphincter Function in Patients With Gastroesophageal Reflux Disease

(2010) Guy E. Boeckxstaens et al.   GASTROENTEROLOGY

A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer

(2010) Ling Wang et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

A double-blind, controlled study comparing lafutidine with placebo and famotidine in Japanese patients with mild reflux esophagitis

(2010) Shuichi Ohara et al.   JOURNAL OF GASTROENTEROLOGY

Nonerosive Reflux Disease (NERD) - An Update

(2010) Tiberiu Hershcovici et al.   Journal of Neurogastroenterology and Motility

Clinical trials: healing of erosive oesophagitis with dexlansoprazole MR, a proton pump inhibitor with a novel dual delayed-release formulation - results from two randomized controlled studies

(2009) P. SHARMA et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: the effect and timing of food on the pharmacokinetics and pharmacodynamics of dexlansoprazole MR, a novel Dual Delayed Release formulation of a proton pump inhibitor - evidence for dosing flexibility

(2009) R. D. LEE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: the effects of the proton pump inhibitor dexlansoprazole MR on daytime and nighttime heartburn in patients with non-erosive reflux disease

(2009) R. FASS et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Proton Pump Inhibitor Failure—What Are the Therapeutic Options?

(2009) Ronnie Fass   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effect of Δ9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans

(2009) H Beaumont et al.   BRITISH JOURNAL OF PHARMACOLOGY

Azithromycin Reduces Gastroesophageal Reflux and Aspiration in Lung Transplant Recipients

(2009) V. Mertens et al.   DIGESTIVE DISEASES AND SCIENCES

Management of heartburn not responding to proton pump inhibitors

(2009) R Fass et al.   GUT

The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying

(2009) Seiji Futagami et al.   JOURNAL OF GASTROENTEROLOGY

Arbaclofen Placarbil, a Novel R-Baclofen Prodrug: Improved Absorption, Distribution, Metabolism, and Elimination Properties Compared with R-Baclofen

(2009) R. Lal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z

(2008) R. H. HUNT et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

(2008) Martin J. Gunthorpe et al.   DRUG DISCOVERY TODAY