Review
Multidisciplinary Sciences
Amanda J. Krause, Erin H. Walsh, Philip A. Weissbrod, Tiffany H. Taft, Rena Yadlapati
Summary: Laryngopharyngeal reflux (LPR) is a syndrome caused by the reflux of gastric contents into the pharynx or larynx, leading to a variety of symptoms. Treatment options for LPR include medical therapies such as proton pump inhibitors and noninvasive treatment options like lifestyle therapy. Due to the complexity of patients with LPR, a treatment algorithm is proposed to assist clinicians in diagnosing and treating patients effectively.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ahsen Ustaoglu, Akinari Sawada, Chung Lee, Wei-Yi Lei, Chien-Lin Chen, Richard Hackett, Daniel Sifrim, Madusha Peiris, Philip Woodland
Summary: This study demonstrates that increased pain perception in patients with nonerosive reflux disease may result from the expression of acid-sensitive channels on superficial mucosal afferents and esophageal epithelial cells. This raises the potential for topical therapy as a treatment option.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Rupinder Mann, Mahesh Gajendran, Abhilash Perisetti, Hemant Goyal, Shreyas Saligram, Chandraprakash Umapathy
Summary: Gastroesophageal reflux disease (GERD) is a common gastrointestinal disease that can be diagnosed based on clinical presentation and risk factors, although atypical symptoms may make diagnosis challenging. Advanced endoscopic techniques have been developed to enhance the diagnosis of GERD and related complications, providing improved detection of subtle irregularities in the mucosa and vascular structures.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Ni-Na Zhang, Yi-Min Ma, Qi Sun, Liang-Liang Shi, Yin Xie, Xiao-Ping Zou
Summary: The study compared the efficacy of LCI and WLI endoscopy in evaluating MCL in patients with NERD, and found that the frequency of MCL was higher in NERD patients than in those with non-GERD. LCI was more sensitive in detecting MCL compared with WLI.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Dhyanesh Patel, Ronnie Fass, Michael Vaezi
Summary: Heartburn is a common clinical symptom, with up to 70% of patients having normal upper endoscopy findings; nonerosive reflux disease (NERD) and functional esophageal disorders are the main causes, with different treatment approaches.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Rena Yadlapati, C. Prakash Gyawali, John E. Pandolfino
Summary: This review outlines a personalized diagnostic and therapeutic approach to GERD symptoms and provides detailed recommendations for clinical practice.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Ye Zhao, Teng Ma, Duowu Zou
Summary: This study identified 1195 differentially expressed genes in NERD patients through RNA sequencing, and identified THY1, BMP2, LOX, KDR, and MMP9 as hub genes in NERD. These hub genes showed diagnostic potential through quantitative PCR analysis, and gene set enrichment analysis indicated their close association with the pathophysiological processes of NERD. Additionally, a regulatory network including transcription factors, miRNAs, and hub genes was established.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Computer Science, Artificial Intelligence
Junkai Liao, Hak-Keung Lam, Guangyu Jia, Shraddha Gulati, Julius Bernth, Dmytro Poliyivets, Yujia Xu, Hongbin Liu, Bu Hayee
Summary: This study aims to automatically diagnose nonerosive reflux disease (NERD) using deep learning algorithms with near focus narrow band imaging (NF-NBI) images. By extracting regions of interest and training CNN models, the ROI-based CNN models demonstrate higher classification performance in both subject-dependent and subject-independent experiments. The results suggest that the proposed ROI-based algorithms are effective in assisting clinical diagnosis of NERD.
Review
Gastroenterology & Hepatology
Joan W. Chen, Marcelo F. Vela, Kathryn A. Peterson, Dustin A. Carlson
Summary: This article provides practical advice for the clinical management of patients with suspected extraesophageal gastroesophageal reflux disease. The advice is based on available evidence from published studies, clinical trials, and clinical guidelines. It emphasizes the importance of considering extraesophageal manifestations of gastroesophageal reflux disease and the need for a multidisciplinary approach in diagnosis and treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Xia Li, Haomeng Wu, Beihua Zhang, Ting Chen, Xiaoshuang Shi, Jinxin Ma, Jiaqi Zhang, Xudong Tang, Fengyun Wang
Summary: This article introduces a randomized controlled trial design on the combination of TCM granules and proton pump inhibitors (PPIs) for non-erosive reflux disease (NERD) treatment. The trial aims to explore the synergistic efficiency of TCM and PPIs, as well as whether the dosage of PPIs can be reduced after the addition of TCM granules, providing a feasible plan to reduce dependencies or withdraw NERD patients from PPIs.
Article
Medicine, General & Internal
Decai Zhang, Shaojun Liu, Zhaoqi Li, Rui Wang
Summary: This study evaluated the latest epidemiologic patterns and trends for GERD using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. The results showed that the burden of GERD is continuing to worsen, with a higher prevalence among females compared to males. Higher socio-demographic index (SDI) was associated with lower incidence and years of life lived with disability (YLDs) for GERD in 2019.
ANNALS OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sachchida Nand Rai, Payal Singh, Harry W. M. Steinbusch, Emanuel Vamanu, Ghulam Ashraf, Mohan Prasad Singh
Summary: It is essential to maintain the recommended daily allowance of vitamins to prevent neurodegenerative diseases and ensure neuronal health. Different types of vitamins have varying effects on neurodegeneration, with some showing therapeutic activity while others may exhibit toxic effects.
Review
Biochemistry & Molecular Biology
Smara Sigdel, Sabrina Swenson, Jinju Wang
Summary: Neurodegenerative diseases affect millions of people worldwide, and their prevalence has increased with longer life expectancy. Despite significant attention, effective treatments for these diseases are lacking due to limited knowledge of their development and progression mechanisms. Extracellular vesicles (EVs) are small particles enclosed in lipid layers found in tissues and biological fluids, and they are increasingly recognized as important mediators in the pathogenesis of neurodegenerative disorders. This review summarizes recent findings on the role of EVs in neurodegenerative diseases and highlights the current limitations in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Gui Chen, Weixing Liu, Wenjing Liao, Lijuan Song, Pingchang Yang, Xiaowen Zhang
Summary: This study found high detection rates of GERD and LPRD at the digestive endoscopy center in Guangzhou, China. Older age, BMI >= 24.0 kg/m(2), smoking, and drinking history were identified as risk factors for both GERD and LPRD. Neither GerdQ nor RSI scores included common extraesophageal symptoms.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Jean A. Boutin, Ralf Jockers
Summary: The article highlights the controversies and limitations in the field of melatonin research, calling for discussion and proposing guidelines to advance the field.
JOURNAL OF PINEAL RESEARCH
(2021)
