Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint

Targeting Membrane Lipid a Potential Cancer Cure?

(2017) Loh Teng-Hern Tan et al.   Frontiers in Pharmacology

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

SapC-DOPS Nanovesicles as Targeted Therapy for Lung Cancer

(2015) S. Zhao et al.   MOLECULAR CANCER THERAPEUTICS

Ras moves to stay in place

(2015) Malte Schmick et al.   TRENDS IN CELL BIOLOGY

Clickable Analogue of Cerulenin as Chemical Probe to Explore Protein Palmitoylation

(2014) Baohui Zheng et al.   ACS Chemical Biology

Squalene Synthase Induces Tumor Necrosis Factor Receptor 1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis

(2014) Yi-Fang Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lipid Rafts, Endoplasmic Reticulum and Mitochondria in the Antitumor Action of the Alkylphospholipid Analog Edelfosine

(2014) Consuelo Gajate et al.   Anti-Cancer Agents in Medicinal Chemistry

Membrane rafts as a novel target in cancer therapy

(2014) Anita Hryniewicz-Jankowska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport

(2014) Malte Schmick et al.   CELL

Dividing Cells Regulate Their Lipid Composition and Localization

(2014) G. Ekin Atilla-Gokcumen et al.   CELL

Lipids in cell biology: how can we understand them better?

(2014) Eleonora Muro et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of Cholesterol in Lipid Rafts

(2014) Laura Toppozini et al.   PHYSICAL REVIEW LETTERS

Preparation of Artificial Plasma Membrane Mimicking Vesicles with Lipid Asymmetry

(2014) Qingqing Lin et al.   PLoS One

Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

(2014) María Cristina Estañ et al.   PLoS One

Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome

(2014) Larisa V. Lysenko et al.   PLoS One

Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma

(2013) K. Muir et al.   CANCER RESEARCH

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

(2013) H. Ding et al.   HAEMATOLOGICA

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells

(2013) Toshiro Migita et al.   INTERNATIONAL JOURNAL OF CANCER

Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells

(2013) RISA SHIRAGAMI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Exchange between Borrelia burgdorferi and Host Cells

(2013) Jameson T. Crowley et al.   PLoS Pathogens

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer

(2012) Melis Kartal Yandım et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Statins and cancer: Current and future prospects

(2012) Maja Osmak   CANCER LETTERS

Active Remodeling of Cortical Actin Regulates Spatiotemporal Organization of Cell Surface Molecules

(2012) Kripa Gowrishankar et al.   CELL

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

(2012) Shobhna Kapoor et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Cyclotides Insert into Lipid Bilayers to Form Membrane Pores and Destabilize the Membrane through Hydrophobic and Phosphoethanolamine-specific Interactions

(2012) Conan K. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidomic analysis of phospholipids from human mammary epithelial and breast cancer cell lines

(2012) M. Luísa Dória et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adhesion-mediated cytoskeletal remodeling is controlled by the direct scaffolding of Src from FAK complexes to lipid rafts by SSeCKS/AKAP12

(2012) B Su et al.   ONCOGENE

Lipid raft: A floating island of death or survival

(2012) Kimberly S. George et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Temperature–pressure phase diagram of a heterogeneous anionic model biomembrane system: Results from a combined calorimetry, spectroscopy and microscopy study

(2011) Shobhna Kapoor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Asymmetric GUVs Prepared by MβCD-Mediated Lipid Exchange: An FCS Study

(2011) Salvatore Chiantia et al.   BIOPHYSICAL JOURNAL

Src family kinases mediate epidermal growth factor receptor signaling from lipid rafts in breast cancer cells

(2011) Mary E. Irwin et al.   CANCER BIOLOGY & THERAPY

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum

(2011) C Gajate et al.   ONCOGENE

Chronic Cholesterol Depletion Using Statin Impairs the Function and Dynamics of Human Serotonin1AReceptors

(2010) Sandeep Shrivastava et al.   BIOCHEMISTRY

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer

(2010) Chunyang Wang et al.   EUROPEAN UROLOGY

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

(2010) Mary E. Irwin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Membrane-Mediated Induction and Sorting of K-Ras Microdomain Signaling Platforms

(2010) Katrin Weise et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Rafts of the Medusa: cholesterol targeting in cancer therapy

(2010) M R Freeman et al.   ONCOGENE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Lipid raft connection between extrinsic and intrinsic apoptotic pathways

(2009) Consuelo Gajate et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

(2009) William E Tidyman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Targeting Phosphatidylserine in Anti-Cancer Therapy

(2009) Heidi Kenis et al.   CURRENT PHARMACEUTICAL DESIGN

Farnesyltransferase Inhibitor as Anticancer Agent

(2009) Anuj Agrawal et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

EFFECT OF SIMVASTATIN ON GLIOMA CELL PROLIFERATION, MIGRATION, AND APOPTOSIS

(2009) Hongtao Wu et al.   NEUROSURGERY

A Raft-Associated Species of Phosphatidylethanolamine Interacts with Cholesterol Comparably to Sphingomyelin. A Langmuir-Blodgett Monolayer Study

(2009) Michal Grzybek et al.   PLoS One

Involvement of Raft Aggregates Enriched in Fas/CD95 Death-Inducing Signaling Complex in the Antileukemic Action of Edelfosine in Jurkat Cells

(2009) Consuelo Gajate et al.   PLoS One

The role of caveolin-1 in prostate cancer: clinical implications

(2009) T C Thompson et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Effect of Cholesterol and Ergosterol on the Compressibility and Volume Fluctuations of Phospholipid-Sterol Bilayers in the Critical Point Region: A Molecular Acoustic and Calorimetric Study

(2008) Roland Krivanek et al.   BIOPHYSICAL JOURNAL

Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity

(2008) Debanjan Goswami et al.   CELL

Edelfosine Is Incorporated into Rafts and Alters Their Organization

(2008) Alessio Ausili et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY