Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer

Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells

(2012) Esen Yonca Bassoy et al.   BIOMEDICINE & PHARMACOTHERAPY

A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; ceramide synthase and ceramide clearance genes

(2011) Emel B. Gencer et al.   ANNALS OF HEMATOLOGY

Suppression of Glucosylceramide Synthase Restores p53-Dependent Apoptosis in Mutant p53 Cancer Cells

(2011) Y.-Y. Liu et al.   CANCER RESEARCH

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

(2011) Yusuf Baran et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloidleukemia cells

(2011) Aylin Camgoz et al.   LEUKEMIA & LYMPHOMA

Resveratrol Triggers Apoptosis Through Regulating Ceramide Metabolizing Genes in Human K562 Chronic Myeloid Leukemia Cells

(2011) Melis Kartal et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Three unrelated sphingomyelin analogs spontaneously cluster into plasma membrane micrometric domains

(2010) D. Tyteca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment

(2010) Jessica Tuuf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Importance of cytochrome c redox state for ceramide-induced apoptosis of human mammary adenocarcinoma cells

(2010) Arti Parihar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Co-suppression of MDR1 (multidrug resistance 1) and GCS（glucosylceramide synthase）restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi)

(2010) Xiaofang Zhang et al.   CANCER BIOLOGY & THERAPY

Therapeutic applications of bioactive sphingolipids in hematological malignancies

(2010) Huseyin Atakan Ekiz et al.   INTERNATIONAL JOURNAL OF CANCER

Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: In vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells

(2010) Akhtar Siddiqui et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Drug target identification in sphingolipid metabolism by computational systems biology tools: Metabolic control analysis and metabolic pathway analysis

(2010) F. Betül Kavun Özbayraktar et al.   JOURNAL OF BIOMEDICAL INFORMATICS

The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells

(2010) Zeynep Cakir et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

(2010) Yong-Yu Liu et al.   Molecular Cancer

Sphingolipids and expression regulation of genes in cancer

(2010) Gauri A. Patwardhan et al.   PROGRESS IN LIPID RESEARCH

Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars

(2010) Amar Ghisaidoobe et al.   ACS Medicinal Chemistry Letters

Potential Mechanisms Involved in Ceramide-induced Apoptosis in Human Colon Cancer HT29 Cells

(2009) Jing WANG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Molecular facets of sphingolipids: Mediators of diseases

(2009) Fatma Betul Kavun Ozbayraktar et al.   Biotechnology Journal

Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs

(2009) Yanlin Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

GCS induces multidrug resistance by regulating apoptosis-related genes in K562/AO2 cell line

(2009) Yan Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

(2009) Gauri A. Patwardhan et al.   PLoS One

A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis

(2009) Kohki Fujikawa et al.   TETRAHEDRON LETTERS

Functions of sphingolipid metabolism in mammals — Lessons from genetic defects

(2008) Frédérique Sabourdy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

A role for ceramide in driving cancer cell resistance to doxorubicin

(2008) Yong-Yu Liu et al.   FASEB JOURNAL

De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma

(2008) Geraldine Rath et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of glycosphingolipid-enriched microdomains in innate immunity: Microdomain-dependent phagocytic cell functions

(2007) Fumiko Yoshizaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends

(2007) Sen-itiroh Hakomori   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells

(2007) Ping Xie et al.   LEUKEMIA RESEARCH