Asymmetric cell division: Implications for glioma development and treatment

Mouse Models to Interrogate the Implications of the Differentiation Status In the Ontogeny of Gliomas

(2015) Diana Marcela Muñoz et al.   Oncotarget

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1

(2015) Alexander Gont et al.   Oncotarget

Pathways to Tumorigenesis—Modeling Mutation Acquisition in Stem Cells and Their Progeny

(2015) Rina Ashkenazi et al.   NEOPLASIA

Marker-independent Method for Isolating Slow-Dividing Cancer Stem Cells in Human Glioblastoma

(2015) Cristina Richichi et al.   NEOPLASIA

Deconstruction of Medulloblastoma Cellular Heterogeneity Reveals Differences between the Most Highly Invasive and Self-Renewing Phenotypes

(2015) Ludivine Coudière Morrison et al.   NEOPLASIA

Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas

(2013) André de Macedo Bianco et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3

(2013) Shuken Boku et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial

(2013) Maria Teresa Solomón et al.   BMC CANCER

Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion

(2013) M Nakada et al.   BRITISH JOURNAL OF CANCER

Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

(2013) Karina Kristoffersen et al.   CANCER BIOLOGY & THERAPY

Interleukin-6 is overexpressed and augments invasiveness of human glioma stem cells in vitro

(2013) Bo Qiu et al.   CLINICAL & EXPERIMENTAL METASTASIS

Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition

(2013) Y. Piao et al.   CLINICAL CANCER RESEARCH

Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome

(2013) Cecilie Jonsgar Sandberg et al.   EXPERIMENTAL CELL RESEARCH

Brain Tumour Stem Cells and Neural Stem Cells: Still Explored by the Same Approach?

(2013) W Liu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

(2013) Felipe Ortega et al.   NATURE CELL BIOLOGY

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences

(2013) David V Hansen et al.   NATURE NEUROSCIENCE

Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme

(2013) N. El Hindy et al.   NEURO-ONCOLOGY

Survival and Prognostic Factors of Anaplastic Gliomas

(2013) Miriam Nuño et al.   NEUROSURGERY

Comparison of Survival Between Cerebellar and Supratentorial Glioblastoma Patients

(2013) Sunil Jeswani et al.   NEUROSURGERY

Akt and c-Myc Induce Stem-Cell Markers in Mature Primary p53−/− Astrocytes and Render These Cells Gliomagenic in the Brain of Immunocompetent Mice

(2013) Josefine Radke et al.   PLoS One

Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice

(2013) Giovanna Ponti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential transformation capacity of neuro-glial progenitors during development

(2013) D. M. Munoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro

(2013) S. J. Habib et al.   SCIENCE

Wnt activation promotes neuronal differentiation of Glioblastoma

(2013) E Rampazzo et al.   Cell Death & Disease

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex

(2013) Bridget E. LaMonica et al.   Nature Communications

Epidemiology of primary brain tumors in childhood and adolescence in Kuwait

(2013) Kenneth Chukwuka Katchy et al.   SpringerPlus

Balancing self-renewal and differentiation by asymmetric division: Insights from brain tumor suppressors in Drosophila neural stem cells

(2012) Kai Chen Chang et al.   BIOESSAYS

Association ofKRASandEGFRmutations with survival in patients with advanced lung adenocarcinomas

(2012) Melissa L. Johnson et al.   CANCER

Transcription factor PROX1: its role in development and cancer

(2012) Tamador Elsir et al.   CANCER AND METASTASIS REVIEWS

Innate Neural Stem Cell Heterogeneity Determines the Patterning of Glioma Formation in Children

(2012) Da Yong Lee et al.   CANCER CELL

Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics

(2012) X. Gao et al.   CANCER RESEARCH

Asymmetric Segregation of the Double-Stranded RNA Binding Protein Staufen2 during Mammalian Neural Stem Cell Divisions Promotes Lineage Progression

(2012) Gretchen Kusek et al.   Cell Stem Cell

Walker 256 tumour cells increase substance P immunoreactivity locally and modify the properties of the blood–brain barrier during extravasation and brain invasion

(2012) Kate M. Lewis et al.   CLINICAL & EXPERIMENTAL METASTASIS

Developmental origins of brain tumors

(2012) Chong Liu et al.   CURRENT OPINION IN NEUROBIOLOGY

Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates

(2012) Yuji Tsunekawa et al.   EMBO JOURNAL

Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F]Fluoroethyl-l-tyrosine PET in comparison to MRI

(2012) Norbert Galldiks et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The Impact of Extent of Resection and Histological Subtype on the Outcome of Adult Patients with High-grade Gliomas

(2012) S. Yamaguchi et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Paediatric brain tumours treated at a single, tertiary paediatric neurosurgical referral centre from 1999 to 2010 in Australia

(2012) Mahesh Ramanan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Targeting classical but not neurogenic inflammation reduces peritumoral oedema in secondary brain tumours

(2012) Kate M. Lewis et al.   JOURNAL OF NEUROIMMUNOLOGY

Local generation of glia is a major astrocyte source in postnatal cortex

(2012) Woo-Ping Ge et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Relationship of glioblastoma multiforme to the subventricular zone is associated with survival

(2012) Nazia F. Jafri et al.   NEURO-ONCOLOGY

MEK Is a Key Regulator of Gliogenesis in the Developing Brain

(2012) Xiaoyan Li et al.   NEURON

The Contribution of Notch Signaling to Glioblastoma via Activation of Cancer Stem Cell Self-renewal

(2012) Demirkan B. Gürsel et al.   NEUROSURGERY

RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI3 Kinase/Akt Signaling Pathways

(2012) Jun Muto et al.   PLoS One

Activin A Promotes Neuronal Differentiation of Cerebrocortical Neural Progenitor Cells

(2012) Griselda Rodríguez-Martínez et al.   PLoS One

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase Activity

(2012) Xiuli Jiang et al.   STEM CELLS

Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice

(2012) Cathy Lee et al.   STEM CELLS

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry

(2012) J S Tchorz et al.   Cell Death & Disease

Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells

(2012) Daisuke Sakai et al.   PLoS Genetics

Oncolytic Herpes Simplex Virus Counteracts the Hypoxia-Induced Modulation of Glioblastoma Stem-Like Cells

(2012) Donatella Sgubin et al.   Stem Cells Translational Medicine

EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance

(2012) Hui-Wen Lo   Current Molecular Pharmacology

Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia

(2011) Hiroto Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evidence for label-retaining tumour-initiating cells in human glioblastoma

(2011) Loic P. Deleyrolle et al.   BRAIN

PROX1 is a predictor of survival for gliomas WHO grade II

(2011) T Elsir et al.   BRITISH JOURNAL OF CANCER

Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors

(2011) Sista Sugiarto et al.   CANCER CELL

Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain

(2011) Lionel M.L. Chow et al.   CANCER CELL

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

YB-1 Bridges Neural Stem Cells and Brain Tumor-Initiating Cells via Its Roles in Differentiation and Cell Growth

(2011) A. Fotovati et al.   CANCER RESEARCH

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Age-dependent fate and lineage restriction of single NG2 cells

(2011) X. Zhu et al.   DEVELOPMENT

An Ana2/Ctp/Mud Complex Regulates Spindle Orientation in Drosophila Neuroblasts

(2011) Cheng Wang et al.   DEVELOPMENTAL CELL

Central nervous system (CNS) tumor trends in children in a western Canadian province: a population-based 22-year retrospective study

(2011) Rhonda J. Rosychuk et al.   JOURNAL OF NEUROLOGY

Pediatric Central Nervous System Tumors

(2011) Ricardo Silva Pinho et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Wnt activation is implicated in glioblastoma radioresistance

(2011) Yonghyun Kim et al.   LABORATORY INVESTIGATION

siRNA targeting Notch-1 decreases glioma stem cell proliferation and tumor growth

(2011) Jianpeng Wang et al.   MOLECULAR BIOLOGY REPORTS

A new subtype of progenitor cell in the mouse embryonic neocortex

(2011) Xiaoqun Wang et al.   NATURE NEUROSCIENCE

Sonic Hedgehog and Notch Signaling Can Cooperate to Regulate Neurogenic Divisions of Neocortical Progenitors

(2011) Richa K. Dave et al.   PLoS One

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype

(2011) Liang Lei et al.   PLoS One

The Probable Cell of Origin of NF1- and PDGF-Driven Glioblastomas

(2011) Dolores Hambardzumyan et al.   PLoS One

Dose-dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor

(2011) Lan Dai et al.   PROTEOMICS

Combination of a Ptgs2 Inhibitor and an Epidermal Growth Factor Receptor-Signaling Inhibitor Prevents Tumorigenesis of Oligodendrocyte Lineage-Derived Glioma-Initiating Cells

(2011) Takuichiro Hide et al.   STEM CELLS

Modification of Pax6 and Olig2 Expression in Adult Hippocampal Neurogenesis Selectively Induces Stem Cell Fate and Alters Both Neuronal and Glial Populations

(2011) Friederike Klempin et al.   STEM CELLS

JAM-C is an Apical Surface Marker for Neural Stem Cells

(2011) Sandra Stelzer et al.   STEM CELLS AND DEVELOPMENT

Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions

(2011) J D Lathia et al.   Cell Death & Disease

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

Non-Stem Cell Origin for Oligodendroglioma

(2010) Anders I. Persson et al.   CANCER CELL

A Malignant Oligarchy: Progenitors Govern the Behavior of Oligodendrogliomas

(2010) Yanxin Pei et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Epidermal Growth Factor Receptor Expression Identifies Functionally and Molecularly Distinct Tumor-Initiating Cells in Human Glioblastoma Multiforme and Is Required for Gliomagenesis

(2010) S. Mazzoleni et al.   CANCER RESEARCH

Regulated Segregation of Kinase Dyrk1A during Asymmetric Neural Stem Cell Division Is Critical for EGFR-Mediated Biased Signaling

(2010) Sacri R. Ferron et al.   Cell Stem Cell

Mechanisms that regulate the number of neurons during mouse neocortical development

(2010) Takaki Miyata et al.   CURRENT OPINION IN NEUROBIOLOGY

Nervous system tumors associated with familial tumor syndromes

(2010) Hiroko Ohgaki et al.   CURRENT OPINION IN NEUROLOGY

Notch regulates the switch from symmetric to asymmetric neural stem cell division in the Drosophila optic lobe

(2010) B. Egger et al.   DEVELOPMENT

Notch as a molecular switch in neural stem cells

(2010) Zhi-Dong Zhou et al.   IUBMB LIFE

Expression of PROX1 Is a Common Feature of High-Grade Malignant Astrocytic Gliomas

(2010) Tamador Elsir et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Accumulation of CD133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation

(2010) Kaoru Tamura et al.   JOURNAL OF NEUROSURGERY

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Microenvironmental modulation of asymmetric cell division in human lung cancer cells

(2010) S. R. Pine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate

(2010) Francesca Pistollato et al.   STEM CELLS

Mitochondrial DNA Integrity Is Essential For Mitochondrial Maturation During Differentiation of Neural Stem Cells

(2010) Wei Wang et al.   STEM CELLS

Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell Intermediate

(2010) Koos E. Hovinga et al.   STEM CELLS

Stem Cells, Radial Glial Cells, and a Unified Origin of Brain Tumors

(2009) M. Castillo   AMERICAN JOURNAL OF NEURORADIOLOGY

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Arsenic trioxide-mediated Notch pathway inhibition depletes the cancer stem-like cell population in gliomas

(2009) Yunbo Zhen et al.   CANCER LETTERS

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells

(2009) C. Wang et al.   DEVELOPMENT

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

(2009) Masakazu Namihira et al.   DEVELOPMENTAL CELL

Therapeutic implications of cancer initiating cells

(2009) Alessandro Scopelliti et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors

(2009) Qinghai Liu et al.   JOURNAL OF NEURO-ONCOLOGY

The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo

(2009) Peng Xu et al.   JOURNAL OF NEURO-ONCOLOGY

Cyclin D2 Is Critical for Intermediate Progenitor Cell Proliferation in the Embryonic Cortex

(2009) S. B. Glickstein et al.   JOURNAL OF NEUROSCIENCE

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In vitro

(2009) A. M. McCord et al.   MOLECULAR CANCER RESEARCH

Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

(2009) Celia Andreu-Agulló et al.   NATURE NEUROSCIENCE

Mammalian Par3 Regulates Progenitor Cell Asymmetric Division via Notch Signaling in the Developing Neocortex

(2009) Ronald S. Bultje et al.   NEURON

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

(2009) N Lindberg et al.   ONCOGENE

Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma

(2008) Mi K Kang et al.   BMC NEUROSCIENCE

Differential effects of photodynamic therapy on morphologically distinct tumor cells derived from a single precursor cell

(2008) Toshihiro Kushibiki et al.   CANCER LETTERS

Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth

(2008) S. Bao et al.   CANCER RESEARCH

Potency and Fate Specification in CNS Stem Cell Populations In Vitro

(2008) Rea Ravin et al.   Cell Stem Cell

The PDZ Protein Canoe Regulates the Asymmetric Division of Drosophila Neuroblasts and Muscle Progenitors

(2008) Stephan Speicher et al.   CURRENT BIOLOGY

Polo-like kinase 1 reaches beyond mitosis—cytokinesis, DNA damage response, and development

(2008) Tohru Takaki et al.   CURRENT OPINION IN CELL BIOLOGY

PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos

(2008) Y. Budirahardja et al.   DEVELOPMENT

Constitutive EGFR Signaling in Oligodendrocyte Progenitors Leads to Diffuse Hyperplasia in Postnatal White Matter

(2008) S. Ivkovic et al.   JOURNAL OF NEUROSCIENCE

Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile

(2008) Francois Ducray et al.   Molecular Cancer

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE

Characterization of Numb expression in astrocytomas

(2008) Benedict Yan et al.   NEUROPATHOLOGY

Live Imaging at the Onset of Cortical Neurogenesis Reveals Differential Appearance of the Neuronal Phenotype in Apical versus Basal Progenitor Progeny

(2008) Alessio Attardo et al.   PLoS One

A Sox1 to Pax6 Switch Drives Neuroectoderm to Radial Glia Progression During Differentiation of Mouse Embryonic Stem Cells

(2008) David M. Suter et al.   STEM CELLS