Balancing self-renewal and differentiation by asymmetric division: Insights from brain tumor suppressors in Drosophila neural stem cells

Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila

(2011) Y. Ouyang et al.   DEVELOPMENT

The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila

(2011) Beatriz P. San-Juán et al.   DEVELOPMENTAL BIOLOGY

An Ana2/Ctp/Mud Complex Regulates Spindle Orientation in Drosophila Neuroblasts

(2011) Cheng Wang et al.   DEVELOPMENTAL CELL

Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila

(2011) Y. Song et al.   GENES & DEVELOPMENT

The Rap1–Rgl–Ral signaling network regulates neuroblast cortical polarity and spindle orientation

(2011) Ana Carmena et al.   JOURNAL OF CELL BIOLOGY

Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation

(2011) Brett Wee et al.   JOURNAL OF CELL BIOLOGY

Apical–basal polarity in Drosophila neuroblasts is independent of vesicular trafficking

(2011) Nils Halbsgut et al.   MOLECULAR BIOLOGY OF THE CELL

The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements

(2011) Constance Richter et al.   NATURE CELL BIOLOGY

Epigenetic Licensing of Germline Gene Expression by Maternal RNA in C. elegans

(2011) C. L. Johnson et al.   SCIENCE

Drosophila neuroblasts retain the daughter centrosome

(2011) Jens Januschke et al.   Nature Communications

Cnn Dynamics Drive Centrosome Size Asymmetry to Ensure Daughter Centriole Retention in Drosophila Neuroblasts

(2010) Paul T. Conduit et al.   CURRENT BIOLOGY

Influence of Fat-Hippo and Notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia

(2010) B. V. V. G. Reddy et al.   DEVELOPMENT

Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe

(2010) T. Yasugi et al.   DEVELOPMENT

Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development

(2010) Atsushi Kitajima et al.   DEVELOPMENTAL BIOLOGY

Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal

(2010) Kai Chen Chang et al.   DEVELOPMENTAL CELL

dFezf/Earmuff Maintains the Restricted Developmental Potential of Intermediate Neural Progenitors in Drosophila

(2010) Mo Weng et al.   DEVELOPMENTAL CELL

Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

(2010) Juliette D. Godin et al.   NEURON

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

(2010) A. Janic et al.   SCIENCE

Identification of an Aurora-A/PinsLINKER/ Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells

(2009) Christopher A. Johnston et al.   CELL

aPKC Phosphorylates Miranda to Polarize Fate Determinants during Neuroblast Asymmetric Cell Division

(2009) Scott X. Atwood et al.   CURRENT BIOLOGY

Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells

(2009) C. Wang et al.   DEVELOPMENT

Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal

(2009) Chiswili Chabu et al.   DEVELOPMENTAL BIOLOGY

PP2A Antagonizes Phosphorylation of Bazooka by PAR-1 to Control Apical-Basal Polarity in Dividing Embryonic Neuroblasts

(2009) Michael P. Krahn et al.   DEVELOPMENTAL CELL

Apical/Basal Spindle Orientation Is Required for Neuroblast Homeostasis and Neuronal Differentiation in Drosophila

(2009) Clemens Cabernard et al.   DEVELOPMENTAL CELL

Protein Phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions

(2009) R. Sousa-Nunes et al.   GENES & DEVELOPMENT

Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions

(2009) H. Ogawa et al.   JOURNAL OF CELL SCIENCE

At the crossroads of polarity, proliferation and apoptosis: The use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression

(2009) Thomas Vaccari et al.   Molecular Oncology

The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death

(2008) L F Grochola et al.   BRITISH JOURNAL OF CANCER

Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization

(2008) Frederik Wirtz-Peitz et al.   CELL

Centrosome Dysfunction in Drosophila Neural Stem Cells Causes Tumors that Are Not Due to Genome Instability

(2008) Elisabeth Castellanos et al.   CURRENT BIOLOGY

The PDZ Protein Canoe Regulates the Asymmetric Division of Drosophila Neuroblasts and Muscle Progenitors

(2008) Stephan Speicher et al.   CURRENT BIOLOGY

Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression

(2008) C. Chabu et al.   DEVELOPMENT

The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila

(2008) Sarah K. Bowman et al.   DEVELOPMENTAL CELL

Identification ofDrosophilatype II neuroblast lineages containing transit amplifying ganglion mother cells

(2008) Jason Q. Boone et al.   Developmental Neurobiology

Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development

(2008) Bruno C Bello et al.   Neural Development

The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression

(2008) A Bonnomet et al.   ONCOGENE