Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 250, Issue 1-2, Pages 59-65Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.06.001
Keywords
Brain metastases; Cerebral oedema; Substance P; NK1 antagonist; Blood-brain barrier; Dexamethasone
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Funding
- Neurosurgical Research Foundation (Australia)
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Dexamethasone, the standard treatment for peritumoral brain oedema, inhibits classical inflammation. Neurogenic inflammation, which acts via substance P (SP), has been implicated in vasogenic oedema in animal models of CNS injury. SP is elevated within and outside CNS tumours. This study investigated the efficacy of NK1 receptor antagonists, which block SP, compared with dexamethasone treatment, in a rat model of tumorigenesis. Dexamethasone reverted normal brain water content and reduced Evans blue and albumin extravasation, while NK1 antagonists did not ameliorate oedema formation. We conclude that classical inflammation rather than neurogenic inflammation drives peritumoral oedema in this brain tumour model. (c) 2012 Elsevier B.V. All rights reserved.
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