Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis

Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis

(2018) Pamela Sarkar et al.   CYTOTHERAPY

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation

(2018) Plamena R. Angelova et al.   Redox Biology

Identifying the optimum source of mesenchymal stem cells for use in knee surgery

(2017) Benjamin M. Davies et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies

(2017) Sreeja Gopal et al.   Multiple Sclerosis Journal

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

(2017) Juliana Redondo et al.   Multiple Sclerosis Journal

Intrinsic Mesenchymal Stem Cell Dysfunction in Diabetes Mellitus: Implications for Autologous Cell Therapy

(2017) Mari van de Vyver   STEM CELLS AND DEVELOPMENT

Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies

(2017) Sreeja Gopal et al.   Multiple Sclerosis Journal

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

(2017) Juliana Redondo et al.   Multiple Sclerosis Journal

Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-β Feedback Loop

(2017) Lin Gao et al.   Arthritis & Rheumatology

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes

(2016) Goutham Vasam et al.   DIABETES

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model

(2016) T. Draheim et al.   GLIA

Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis

(2016) Itzy E. Morales Pantoja et al.   JOURNAL OF NEUROCHEMISTRY

Effects of Oxidative Stress on Mesenchymal Stem Cell Biology

(2016) Ryan A. Denu et al.   Oxidative Medicine and Cellular Longevity

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53–SIRT1 axis

(2016) D S Yoon et al.   Cell Death & Disease

Oxidative stress signaling to chromatin in health and disease

(2016) Sarah Kreuz et al.   Epigenomics

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reductions in kinesin expression are associated with nitric oxide-induced axonal damage

(2015) Juliana Redondo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Oxidative and nitrative stress in neurodegeneration

(2015) Catherine A. Cobb et al.   NEUROBIOLOGY OF DISEASE

Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation

(2015) Sébastien Sart et al.   Oxidative Medicine and Cellular Longevity

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment

(2014) Maira Gironi et al.   Journal of Immunology Research

Translational control of Nrf2 within the open reading frame

(2013) Oscar Perez-Leal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach

(2013) Genaro G. Ortiz et al.   Clinical & Developmental Immunology

Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases

(2013) Claire M Rice et al.   LANCET

Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

(2012) Maarten E. Witte et al.   ACTA NEUROPATHOLOGICA

Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity

(2012) Mohammad Mohammadzadeh et al.   CELL STRESS & CHAPERONES

Type 2 diabetes and bone

(2012) William D Leslie et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

(2011) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inflammation and mesenchymal stem cell aging

(2011) Günter Lepperdinger   CURRENT OPINION IN IMMUNOLOGY

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?

(2011) Eduardo Mansilla et al.   Stem Cells International

Chondrogenic differentiation in femoral bone marrow-derived mesenchymal cells (MSC) from elderly patients suffering osteoarthritis or femoral fracture

(2010) Felícito García-Álvarez et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis

(2010) Elizabeth Mallam et al.   Multiple Sclerosis Journal

PGC-1alpha Down-Regulation Affects the Antioxidant Response in Friedreich's Ataxia

(2010) Daniele Marmolino et al.   PLoS One

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

(2009) Delinda A. Johnson et al.   TOXICOLOGICAL SCIENCES

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis

(2007) M-C Kastrinaki et al.   ANNALS OF THE RHEUMATIC DISEASES