A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

Integrin α4β7 Expression Increases HIV Susceptibility in Activated Cervical CD4+ T Cells by an HIV Attachment-Independent Mechanism

(2015) Jian Ding et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication

(2015) Simone I Richardson et al.   Retrovirology

Targeting of gut specific leucocyte recruitment in IBD by vedolizumab

(2014) Bertus Eksteen   GUT

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

(2014) Siddappa N Byrareddy et al.   NATURE MEDICINE

Sex Hormones Selectively Impact the Endocervical Mucosal Microenvironment: Implications for HIV Transmission

(2014) Diana Goode et al.   PLoS One

HSV-2-Driven Increase in the Expression of α4β7 Correlates with Increased Susceptibility to Vaginal SHIVSF162P3 Infection

(2014) Diana Goode et al.   PLoS Pathogens

Orally available and efficacious α4β1/α4β7 integrin inhibitors

(2013) Ying-zi Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Frequency of α4β7high Memory CD4+ T Cells Correlates With Susceptibility to Rectal Simian Immunodeficiency Virus Infection

(2013) Elena Martinelli et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Phenotypic properties of transmitted founder HIV-1

(2013) N. F. Parrish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural specializations of α4β7, an integrin that mediates rolling adhesion

(2012) Yamei Yu et al.   JOURNAL OF CELL BIOLOGY

Transmitted/Founder and Chronic Subtype C HIV-1 Use CD4 and CCR5 Receptors with Equal Efficiency and Are Not Inhibited by Blocking the Integrin α4β7

(2012) Nicholas F. Parrish et al.   PLoS Pathogens

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

An Antiretroviral/Zinc Combination Gel Provides 24 Hours of Complete Protection against Vaginal SHIV Infection in Macaques

(2011) Jessica Kenney et al.   PLoS One

Early Divergent Host Responses in SHIVsf162P3 and SIVmac251 Infected Macaques Correlate with Control of Viremia

(2011) Huanbin Xu et al.   PLoS One

HSV-2 Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target

(2011) Elena Martinelli et al.   PLoS Pathogens

The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission

(2011) Fatima Nawaz et al.   PLoS Pathogens

Small Molecule Antagonists of Integrin Receptors

(2010) A. Perdih et al.   CURRENT MEDICINAL CHEMISTRY

Blocking of  4 7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2010) A. A. Ansari et al.   JOURNAL OF IMMUNOLOGY

Role of β7 Integrins in Intestinal Lymphocyte Homing and Retention

(2009) G. Gorfu et al.   CURRENT MOLECULAR MEDICINE

Anti-integrin monoclonal antibodies

(2009) A. Byron et al.   JOURNAL OF CELL SCIENCE

CD4 T cell subsets in the mucosa are CD28+Ki-67−HLA-DR−CD69+but show differential infection based on α4β7 receptor expression during acute SIV infection

(2009) M. Kader et al.   JOURNAL OF MEDICAL PRIMATOLOGY

α4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection

(2009) M Kader et al.   Mucosal Immunology

The integrin  4 7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

(2009) C. Cicala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Concepts in the Immunopathogenesis of AIDS

(2008) Daniel C. Douek et al.   Annual Review of Medicine

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY