Vaccines: From Empirical Development to Rational Design

Intranasal vaccination with an adjuvanted Norwalk virus-like particle vaccine elicits antigen-specific B memory responses in human adult volunteers

(2012) Karina Ramirez et al.   CLINICAL IMMUNOLOGY

Bacteria and their Toxins Tamed for Immunotherapy

(2012) Irena Adkins et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection

(2012) Brendan M. Giles et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of the Viral O-Glycopeptidome: a Novel Tool of Relevance for Vaccine Design and Serodiagnosis

(2012) E. Clo et al.   JOURNAL OF VIROLOGY

A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines

(2012) Xiaowei Liu et al.   NANO LETTERS

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics

(2012) Mohsen Tafaghodi et al.   VACCINE

Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41

(2012) C. Pastori et al.   VIROLOGY

Dengue-1 Envelope Protein Domain III along with PELC and CpG Oligodeoxynucleotides Synergistically Enhances Immune Responses

(2012) Chen-Yi Chiang et al.   PLoS Neglected Tropical Diseases

Immune system simulation online

(2011) N. Rapin et al.   BIOINFORMATICS

POPISK: T-cell reactivity prediction using support vector machines and string kernels

(2011) Chun-Wei Tung et al.   BMC BIOINFORMATICS

Cytokines: The Future of Intranasal Vaccine Adjuvants

(2011) Afton L. Thompson et al.   Clinical & Developmental Immunology

Clinical Applications of DNA Vaccines: Current Progress

(2011) B. Ferraro et al.   CLINICAL INFECTIOUS DISEASES

Systems biology approaches to new vaccine development

(2011) Ann L Oberg et al.   CURRENT OPINION IN IMMUNOLOGY

Viral vectors as vaccine platforms: deployment in sight

(2011) Christine S Rollier et al.   CURRENT OPINION IN IMMUNOLOGY

Salmonellaexpressing detoxified lipopolysaccharide is immunogenic and protective both as an attenuated vaccine and for delivery of foreign antigens

(2011) James E Galen et al.   Expert Review of Vaccines

Innate immune recognition of poxviral vaccine vectors

(2011) Erin L Lousberg et al.   Expert Review of Vaccines

Optimizing vaccine-induced CD8+T-cell immunity: focus on recombinant adenovirus vectors

(2011) Jennifer D Bassett et al.   Expert Review of Vaccines

Current adjuvants and new perspectives in vaccine formulation

(2011) Emanuele Montomoli et al.   Expert Review of Vaccines

CpG DNA as a vaccine adjuvant

(2011) Christian Bode et al.   Expert Review of Vaccines

Leishmaniasis: focus on the design of nanoparticulate vaccine delivery systems

(2011) Delaram Doroud et al.   Expert Review of Vaccines

NetMHCcons: a consensus method for the major histocompatibility complex class I predictions

(2011) Edita Karosiene et al.   IMMUNOGENETICS

Live Attenuated Salmonella Vaccines against Mycobacterium tuberculosis with Antigen Delivery via the Type III Secretion System

(2011) María Dolores Juárez-Rodríguez et al.   INFECTION AND IMMUNITY

Live Attenuated Salmonella Vaccines Displaying Regulated Delayed Lysis and Delayed Antigen Synthesis To Confer Protection against Mycobacterium tuberculosis

(2011) María Dolores Juárez-Rodríguez et al.   INFECTION AND IMMUNITY

Variable HIV peptide stability in human cytosol is critical to epitope presentation and immune escape

(2011) Estibaliz Lazaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

(2011) Nicole Frahm et al.   JOURNAL OF CLINICAL INVESTIGATION

A Virus-Like Particle-Based Epstein-Barr Virus Vaccine

(2011) R. Ruiss et al.   JOURNAL OF VIROLOGY

Attenuated Listeria monocytogenes vaccine vectors expressing Influenza A nucleoprotein: preclinical evaluation and oral inoculation of volunteers

(2011) Paul V. Johnson et al.   MICROBIOLOGY AND IMMUNOLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Designing the Next Generation of Vaccines for Global Public Health

(2011) Fabio Bagnoli et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Vaccinomics and a New Paradigm for the Development of Preventive Vaccines Against Viral Infections

(2011) Gregory A. Poland et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

The Top Five “Game Changers” in Vaccinology: Toward Rational and Directed Vaccine Development

(2011) Richard B. Kennedy et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Innate immunity and adjuvants

(2011) S. Akira   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology

(2011) Madelene Lindqvist et al.   PLoS One

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

(2011) B. J. Flynn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections

(2011) A. Nuccitelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity

(2011) M. Scarselli et al.   Science Translational Medicine

Targeting B cell responses in universal influenza vaccine design

(2011) Kaval Kaur et al.   TRENDS IN IMMUNOLOGY

Boosting antibody responses by targeting antigens to dendritic cells

(2011) Irina Caminschi et al.   TRENDS IN IMMUNOLOGY

Transcutaneous vaccines: Novel advances in technology and delivery for overcoming the barriers

(2011) Ni Li et al.   VACCINE

Induction of mucosal and systemic immunity against respiratory syncytial virus by inactivated virus supplemented with TLR9 and NOD2 ligands

(2011) Muhammad Shafique et al.   VACCINE

A novel combined adjuvant for nasal delivery elicits mucosal immunity to influenza in aging

(2011) Hideki Asanuma et al.   VACCINE

Neutralizing Antibody Response to Hepatitis C Virus

(2011) Yong Wang et al.   Viruses-Basel

Profiling immunity to HIV vaccines with systems biology

(2011) Erica Andersen-Nissen et al.   Current Opinion in HIV and AIDS

“Rational Vaccine Design” for HIV Should Take into Account the Adaptive Potential of Polyreactive Antibodies

(2011) Jordan D. Dimitrov et al.   PLoS Pathogens

Vaccinomics and Personalized Vaccinology: Is Science Leading Us Toward a New Path of Directed Vaccine Development and Discovery?

(2011) Gregory A. Poland et al.   PLoS Pathogens

Systems biology in vaccine design

(2011) Adrien Six et al.   Microbial Biotechnology

Nanoparticles for transcutaneous vaccination

(2011) Steffi Hansen et al.   Microbial Biotechnology

Cyclic di-nucleotides: new era for small molecules as adjuvants

(2011) Rimma Libanova et al.   Microbial Biotechnology

Vaccines for the future: learning from human immunology

(2011) Ennio De Gregorio et al.   Microbial Biotechnology

Peptide binding predictions for HLA DR, DP and DQ molecules

(2010) Peng Wang et al.   BMC BIOINFORMATICS

SVM-based prediction of linear B-cell epitopes using Bayes Feature Extraction

(2010) Lawrence JK Wee et al.   BMC GENOMICS

Mucosal Adjuvants

(2010) Ali M. Harandi et al.   CURRENT HIV RESEARCH

Integrating Genomic Signatures for Immunologic Discovery

(2010) W. Nicholas Haining et al.   IMMUNITY

Immunologic Basis of Vaccine Vectors

(2010) Margaret A. Liu   IMMUNITY

Reverse Vaccinology: Developing Vaccines in the Era of Genomics

(2010) Alessandro Sette et al.   IMMUNITY

Immunization delivered by lentiviral vectors for cancer and infectious diseases

(2010) Biliang Hu et al.   IMMUNOLOGICAL REVIEWS

Major histocompatibility complex class I binding predictions as a tool in epitope discovery

(2010) Claus Lundegaard et al.   IMMUNOLOGY

High Throughput T Epitope Mapping and Vaccine Development

(2010) Giuseppina Li Pira et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines

(2010) Tomonori Nochi et al.   NATURE MATERIALS

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

(2010) Dan H Barouch et al.   NATURE MEDICINE

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys

(2010) Sampa Santra et al.   NATURE MEDICINE

Computational Immunology Meets Bioinformatics: The Use of Prediction Tools for Molecular Binding in the Simulation of the Immune System

(2010) Nicolas Rapin et al.   PLoS One

Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

(2010) Pablo D. Becker et al.   PLoS One

Elicitation of structure-specific antibodies by epitope scaffolds

(2010) G. Ofek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

(2010) S. G. Hansen et al.   SCIENCE

Vaccine adjuvants: A priority for vaccine research

(2010) Ali M. Harandi et al.   VACCINE

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

(2009) Nicolas Legrand et al.   Cell Host & Microbe

Vaccine adjuvants: scientific challenges and strategic initiatives

(2009) Ali M Harandi et al.   Expert Review of Vaccines

OptiTope--a web server for the selection of an optimal set of peptides for epitope-based vaccines

(2009) N. C. Toussaint et al.   NUCLEIC ACIDS RESEARCH

The Immune Epitope Database 2.0

(2009) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses

(2009) I. Amit et al.   SCIENCE

Prevalence of serum neutralizing antibodies against chimpanzee adenovirus 63 and human adenovirus 5 in Kenyan Children, in the context of vaccine vector efficacy

(2009) M. Dudareva et al.   VACCINE

PEPOP: Computational design of immunogenic peptides

(2008) Violaine Moreau et al.   BMC BIOINFORMATICS

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

(2008) Denis Gaucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Predicting linear B‐cell epitopes using string kernels

(2008) Yasser EL‐Manzalawy et al.   JOURNAL OF MOLECULAR RECOGNITION

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

Benchmarking B cell epitope prediction: Underperformance of existing methods

(2004) Martin J. Blythe et al.   PROTEIN SCIENCE