Innate immune recognition of poxviral vaccine vectors

Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition

(2011) E. L. Lousberg et al.   JOURNAL OF VIROLOGY

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors

(2011) Esther D. Quakkelaar et al.   PLoS One

Evaluation of recombinant fowlpox virus expressing infectious bronchitis virus S1 gene and chicken interferon-γ gene for immune protection against heterologous strains

(2011) Xing-Ming Shi et al.   VACCINE

RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis

(2011) Chad Myskiw et al.   VIROLOGY

Inflammasomes as microbial sensors

(2010) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The evolving role of dendritic cells in cancer therapy

(2010) EJ Ilett et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1

(2010) B Huang et al.   GENE THERAPY

Evaluating vaccinia virus cytokine co-expression in TLR GKO mice

(2010) Duncan B Sutherland et al.   IMMUNOLOGY AND CELL BIOLOGY

Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule

(2010) T. Lysakova-Devine et al.   JOURNAL OF IMMUNOLOGY

Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity

(2010) E. L. Lousberg et al.   JOURNAL OF VIROLOGY

Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

(2010) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct TLR2 Signaling Is Critical for NK Cell Activation and Function in Response to Vaccinia Viral Infection

(2010) Jennifer Martinez et al.   PLoS Pathogens

Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4)

(2009) Eyad Elkord et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Antitumor and Immunoadjuvant Effects of IFN-  in Combination with Recombinant Poxvirus Vaccines

(2009) K. W. Hance et al.   CLINICAL CANCER RESEARCH

Interferon-γ: A historical perspective

(2009) Alfons Billiau et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Vaccinia Virus F1L Interacts with Bak Using Highly Divergent Bcl-2 Homology Domains and Replaces the Function of Mcl-1

(2009) Stephanie Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Adaptor Molecule MyD88 Directly Promotes CD8 T Cell Responses to Vaccinia Virus

(2009) Yuan Zhao et al.   JOURNAL OF IMMUNOLOGY

Vaccinia Virus-Based Multivalent H5N1 Avian Influenza Vaccines Adjuvanted with IL-15 Confer Sterile Cross-Clade Protection in Mice

(2009) L. L. M. Poon et al.   JOURNAL OF IMMUNOLOGY

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

The Fowlpox Virus BCL-2 Homologue, FPV039, Interacts with Activated Bax and a Discrete Subset of BH3-Only Proteins To Inhibit Apoptosis

(2009) L. Banadyga et al.   JOURNAL OF VIROLOGY

Clinical phase I intratumoral administration of two recombinant ALVAC canarypox viruses expressing human granulocyte-macrophage colony-stimulating factor or interleukin-2: the transgene determines the composition of the inflammatory infiltrate

(2009) Günther F.L. Hofbauer et al.   MELANOMA RESEARCH

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparing human T cell and NK cell responses in viral-based malaria vaccine trials

(2009) Tamara K. Berthoud et al.   VACCINE

A multi-valent vaccinia virus-based tuberculosis vaccine molecularly adjuvanted with interleukin-15 induces robust immune responses in mice

(2009) Pin-Yu Perera et al.   VACCINE

A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy

(2009) Rajesh T. Gandhi et al.   VACCINE

Multimeric soluble CD40 ligand (sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens

(2009) Carmen E. Gómez et al.   VACCINE

Onset and duration of immunity to equine influenza virus resulting from canarypox-vectored (ALVAC®) vaccination

(2009) Gisela Soboll et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Interleukin-15 mediates potent antiviral responses via an interferon-dependent mechanism

(2009) Y.Y. Foong et al.   VIROLOGY

Modified vaccinia virus Ankara can activate NF-κB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication

(2009) Heather E. Lynch et al.   VIROLOGY

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

(2009) Julie Delaloye et al.   PLoS Pathogens

Co-Regulation of NF-κB and Inflammasome-Mediated Inflammatory Responses by Myxoma Virus Pyrin Domain-Containing Protein M013

(2009) Masmudur M. Rahman et al.   PLoS Pathogens

Adjuvant activity of type I interferons

(2008) Michael G. Tovey et al.   BIOLOGICAL CHEMISTRY

A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection

(2008) M. Quigley et al.   BLOOD

Dendritic Cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo

(2008) Luzheng Liu et al.   BMC IMMUNOLOGY

The Poxvirus Vectors MVA and NYVAC as Gene Delivery Systems for Vaccination Against Infectious Diseases and Cancer

(2008) Carmen Gomez et al.   CURRENT GENE THERAPY

IMVAMUNE®: modified vaccinia Ankara strain as an attenuated smallpox vaccine

(2008) Jeffrey S Kennedy et al.   Expert Review of Vaccines

Interferon type I responses in primary and secondary infections

(2008) Mohammed Alsharifi et al.   IMMUNOLOGY AND CELL BIOLOGY

Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

(2008) Christofer Samuelsson et al.   JOURNAL OF CLINICAL INVESTIGATION

An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses

(2008) Alexandre Harari et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection

(2008) N. Jacobs et al.   JOURNAL OF GENERAL VIROLOGY

Vaccinia Virus Blocks Stat1-Dependent and Stat1-Independent Gene Expression Induced by Type I and Type II Interferons

(2008) Brandon A. Mann et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Vaccinia Virus-Mediated Inhibition of Type I Interferon Responses Is a Multifactorial Process Involving the Soluble Type I Interferon Receptor B18 and Intracellular Components

(2008) Z. Waibler et al.   JOURNAL OF VIROLOGY

CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals

(2008) Jun Liu et al.   VACCINE

EV01: A phase I trial in healthy HIV negative volunteers to evaluate a clade C HIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium

(2008) Pierre-Alexandre Bart et al.   VACCINE

Recombinant fowlpox virus elicits transient cytotoxic T cell responses due to suboptimal innate recognition and recruitment of T cell help

(2008) Kerrilyn R. Diener et al.   VACCINE

Gene profiling analysis of ALVAC infected human monocyte derived dendritic cells

(2008) Anke Harenberg et al.   VACCINE

Vaccinia virus proteins activate human dendritic cells to induce T cell responses in vitro

(2008) Sudhanshu Agrawal et al.   VACCINE

Antagonizing activity of vaccinia virus E3L against human interferons in Huh7 cells

(2008) Janilyn Arsenio et al.   VIROLOGY