“Rational Vaccine Design” for HIV Should Take into Account the Adaptive Potential of Polyreactive Antibodies

The Role of Antibodies in HIV Vaccines

(2010) John R. Mascola et al.   Annual Review of Immunology

Protein binding specificity versus promiscuity

(2010) Gideon Schreiber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Description of Flexibility in an Antibody Combining Site

(2010) Jörg Zimmermann et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

(2010) Hugo Mouquet et al.   NATURE

Pushing the envelope on HIV-1 neutralization

(2010) Joseph G Joyce et al.   NATURE BIOTECHNOLOGY

Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity

(2010) Ron Diskin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolving concepts of specificity in immune reactions

(2010) H. N. Eisen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

(2010) R. Pejchal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

(2010) E. M. Scherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Few and Far Between: How HIV May Be Evading Antibody Avidity

(2010) Joshua S. Klein et al.   PLoS Pathogens

Carbohydrate targets in HIV vaccine research: lessons from failures

(2009) Anastas Pashov et al.   Immunotherapy

HIV-1 and influenza antibodies: seeing antigens in new ways

(2009) Peter D Kwong et al.   NATURE IMMUNOLOGY

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Conformational flexibility and kinetic complexity in antibody–antigen interactions

(2008) Katerina Kourentzi et al.   JOURNAL OF MOLECULAR RECOGNITION

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

(2008) Gunilla B. Karlsson Hedestam et al.   NATURE REVIEWS MICROBIOLOGY