Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions

What Drives Amyloid Molecules To Assemble into Oligomers and Fibrils?

(2011) Jeremy D. Schmit et al.   BIOPHYSICAL JOURNAL

Prediction of Immunogenicity of Therapeutic Proteins

(2010) Christine J. Bryson et al.   BIODRUGS

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

5th European Antibody Congress 2009

(2010) Alain Beck et al.   mAbs

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

(2010) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Immunogenicity of aggregates of recombinant human growth hormone in mouse models

(2009) Amber Haynes Fradkin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Immune Epitope Database 2.0

(2009) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

(2009) S. Pechmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological mechanism underlying the immune response to recombinant human protein therapeutics

(2009) Melody Sauerborn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A

(2008) S. Lacroix-Desmazes et al.   BLOOD

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates

(2008) A DEGROOT et al.   CURRENT OPINION IN PHARMACOLOGY

Safety-Related Regulatory Actions for Biologicals Approved in the United States and the European Union

(2008)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality

(2008) John F. Carpenter et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Bacterial Inclusion Bodies Contain Amyloid-Like Structure

(2008) Lei Wang et al.   PLOS BIOLOGY

β Edge strands in protein structure prediction and aggregation

(2003) Jennifer A. Siepen et al.   PROTEIN SCIENCE